Family history information on essential tremor: Potential biases related to the source of the cases
Identifieur interne : 001F12 ( Istex/Corpus ); précédent : 001F11; suivant : 001F13Family history information on essential tremor: Potential biases related to the source of the cases
Auteurs : Elan D. Louis ; Livia F. Barnes ; Blair Ford ; Ruth OttmanSource :
- Movement Disorders [ 0885-3185 ] ; 2001-03.
English descriptors
Abstract
The proportion of essential tremor (ET) cases that can be attributed to genetic factors is unknown; estimates range from 17–100%. One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self‐selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1040
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ISTEX:15AD9F4CE15AD85EFB5DD9D255606936AB08A2CCLe document en format XML
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One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self‐selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elan D. Louis MD, MS</name><affiliations><json:string>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</json:string><json:string>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Livia F. Barnes MPH</name><affiliations><json:string>Gertrude H. 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One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self‐selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Family history information on essential tremor: Potential biases related to the source of the cases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Family History Information on Essential Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Family history information on essential tremor: Potential biases related to the source of the cases</title></titleInfo><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MD, MS</namePart><affiliation>Gertrude H. 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Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Blair</namePart><namePart type="family">Ford</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ruth</namePart><namePart type="family">Ottman</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>School of Public Health (Epidemiology Division), Columbia University, New York, New York, USA</affiliation><affiliation>Epidemiology of Brain Disorders Research Department, New York State Psychiatric Institute, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">shortCommunication</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-03</dateIssued><dateCaptured encoding="w3cdtf">2000-06-19</dateCaptured><dateValid encoding="w3cdtf">2000-07-04</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">19</extent><extent unit="words">2898</extent></physicalDescription><abstract lang="fr">The proportion of essential tremor (ET) cases that can be attributed to genetic factors is unknown; estimates range from 17–100%. One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self‐selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET. © 2001 Movement Disorder Society.</abstract><note type="funding">NIH - No. NS01863; No. P30 ES09089; </note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>genetics</topic><topic>family history</topic><topic>genetic epidemiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>320</start><end>324</end><total>5</total></extent></part></relatedItem><identifier type="istex">15AD9F4CE15AD85EFB5DD9D255606936AB08A2CC</identifier><identifier type="DOI">10.1002/mds.1040</identifier><identifier type="ArticleID">MDS1040</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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