Geographical difference in Parkinson's disease prevalence within West Scotland
Identifieur interne : 001E55 ( Istex/Corpus ); précédent : 001E54; suivant : 001E56Geographical difference in Parkinson's disease prevalence within West Scotland
Auteurs : Edward J. Newman ; Katherine A. Grosset ; Donald G. GrossetSource :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
English descriptors
Abstract
The wide range in reported prevalence of Parkinson's disease (PD) in the United Kingdom (between 108 and 164 per 100,000) is usually attributed to differences in study methodology. We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7–128.6) and age‐adjusted prevalence was 129.5 (95% CI 119.6–139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7–117.9; women 83.9, CI 65.6–102.2) than South Lanarkshire (men 202.7, CI 175.0–230.4; women 151.1, CI 127.7–174.5), age‐adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Explorationof these factors is justified to explain further such wide variation in PD prevalence. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22359
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ISTEX:EC0583E57D4D41660F26C72D6D5DA06A09C60528Le document en format XML
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We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7–128.6) and age‐adjusted prevalence was 129.5 (95% CI 119.6–139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7–117.9; women 83.9, CI 65.6–102.2) than South Lanarkshire (men 202.7, CI 175.0–230.4; women 151.1, CI 127.7–174.5), age‐adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Explorationof these factors is justified to explain further such wide variation in PD prevalence. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Edward J. Newman MRCP</name><affiliations><json:string>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</json:string></affiliations></json:item><json:item><name>Katherine A. Grosset MD</name><affiliations><json:string>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</json:string></affiliations></json:item><json:item><name>Donald G. Grosset MD</name><affiliations><json:string>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prevalence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prescription database</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The wide range in reported prevalence of Parkinson's disease (PD) in the United Kingdom (between 108 and 164 per 100,000) is usually attributed to differences in study methodology. 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Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. 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We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7–128.6) and age‐adjusted prevalence was 129.5 (95% CI 119.6–139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7–117.9; women 83.9, CI 65.6–102.2) than South Lanarkshire (men 202.7, CI 175.0–230.4; women 151.1, CI 127.7–174.5), age‐adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. 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We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7–128.6) and age‐adjusted prevalence was 129.5 (95% CI 119.6–139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7–117.9; women 83.9, CI 65.6–102.2) than South Lanarkshire (men 202.7, CI 175.0–230.4; women 151.1, CI 127.7–174.5), age‐adjusted rates, both <i>P</i> < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Explorationof these factors is justified to explain further such wide variation in PD prevalence. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Geographical difference in Parkinson's disease prevalence within West Scotland</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Geographical Difference in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Geographical difference in Parkinson's disease prevalence within West Scotland</title></titleInfo><name type="personal"><namePart type="given">Edward J.</namePart><namePart type="family">Newman</namePart><namePart type="termsOfAddress">MRCP</namePart><affiliation>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</affiliation><description>Correspondence: Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katherine A.</namePart><namePart type="family">Grosset</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald G.</namePart><namePart type="family">Grosset</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-02-15</dateIssued><dateCaptured encoding="w3cdtf">2008-05-27</dateCaptured><dateValid encoding="w3cdtf">2008-09-24</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">24</extent><extent unit="words">3679</extent></physicalDescription><abstract lang="en">The wide range in reported prevalence of Parkinson's disease (PD) in the United Kingdom (between 108 and 164 per 100,000) is usually attributed to differences in study methodology. We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7–128.6) and age‐adjusted prevalence was 129.5 (95% CI 119.6–139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7–117.9; women 83.9, CI 65.6–102.2) than South Lanarkshire (men 202.7, CI 175.0–230.4; women 151.1, CI 127.7–174.5), age‐adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Explorationof these factors is justified to explain further such wide variation in PD prevalence. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>prevalence</topic><topic>epidemiology</topic><topic>prescription database</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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