Synchronized brain network associated with essential tremor as revealed by magnetoencephalography
Identifieur interne : 001860 ( Istex/Corpus ); précédent : 001859; suivant : 001861Synchronized brain network associated with essential tremor as revealed by magnetoencephalography
Auteurs : Alfons Schnitzler ; Christian Münks ; Markus Butz ; Lars Timmermann ; Joachim GrossSource :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
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- KwdEn :
Abstract
Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22633
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ISTEX:7E6D38040F0FE650E55FED835E09780D72E86B9CLe document en format XML
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There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alfons Schnitzler MD</name><affiliations><json:string>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</json:string><json:string>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>Christian Münks MD</name><affiliations><json:string>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</json:string><json:string>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>Markus Butz PhD</name><affiliations><json:string>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</json:string><json:string>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>Lars Timmermann MD</name><affiliations><json:string>Department of Neurology, University Hospital Cologne, Cologne, Germany</json:string></affiliations></json:item><json:item><name>Joachim Gross PhD</name><affiliations><json:string>Department of Psychology, Centre for Cognitive Neuroimaging (CCNi), University of Glasgow, Glasgow, Scotland, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>oscillations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coupling</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coherence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>synchronization</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. 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There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. 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elementName="appendix">APPENDIX</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22633.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="41"></count><count type="wordTotal" number="4388"></count></countGroup><titleGroup><title type="main" xml:lang="en">Synchronized brain network associated with essential tremor as revealed by magnetoencephalography<link href="#fn1"></link></title><title type="short" xml:lang="en">Brain Network in Essential Tremor</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Alfons</givenNames><familyName>Schnitzler</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="schnitza@uni-duesseldorf.de">schnitza@uni‐duesseldorf.de</email></contactDetails></creator><creator 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type="main" xml:lang="fr"><title type="main">Abstract</title><p>Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: This work was supported by the Volkswagen Stiftung (I/73240 and I/80191) and the Deutsche Forschungsgemeinschaft (SFB 575).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Synchronized brain network associated with essential tremor as revealed by magnetoencephalography</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Brain Network in Essential Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Synchronized brain network associated with essential tremor as revealed by magnetoencephalography</title></titleInfo><name type="personal"><namePart type="given">Alfons</namePart><namePart type="family">Schnitzler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><affiliation>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><description>Correspondence: Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Moorenstr. 5, D‐40225 Düsseldorf, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Münks</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><affiliation>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Markus</namePart><namePart type="family">Butz</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><affiliation>Department of Neurology, Heinrich‐Heine University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Timmermann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joachim</namePart><namePart type="family">Gross</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychology, Centre for Cognitive Neuroimaging (CCNi), University of Glasgow, Glasgow, Scotland, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-08-15</dateIssued><dateCaptured encoding="w3cdtf">2008-11-26</dateCaptured><dateValid encoding="w3cdtf">2009-03-27</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">2</extent><extent unit="references">41</extent><extent unit="words">4388</extent></physicalDescription><abstract lang="fr">Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole‐scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro‐cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: This work was supported by the Volkswagen Stiftung (I/73240 and I/80191) and the Deutsche Forschungsgemeinschaft (SFB 575).</note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>oscillations</topic><topic>coupling</topic><topic>coherence</topic><topic>synchronization</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1629</start><end>1635</end><total>7</total></extent></part></relatedItem><identifier type="istex">7E6D38040F0FE650E55FED835E09780D72E86B9C</identifier><identifier type="DOI">10.1002/mds.22633</identifier><identifier type="ArticleID">MDS22633</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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