Anorectal function in multiple system atrophy and Parkinson's disease
Identifieur interne : 001859 ( Istex/Corpus ); précédent : 001858; suivant : 001860Anorectal function in multiple system atrophy and Parkinson's disease
Auteurs : Fabrizio Stocchi ; Danilo Badiali ; Laura Vacca ; Lucia D'Alba ; Fiammetta Bracci ; Stefano Ruggieri ; Margherita Torti ; Alfredo Berardelli ; Enrico CorazziariSource :
- Movement Disorders [ 0885-3185 ] ; 2000-01.
English descriptors
Abstract
This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p <0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.
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DOI: 10.1002/1531-8257(200001)15:1<71::AID-MDS1012>3.0.CO;2-W
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ISTEX:FF7B1906F005DF50C0029B7ED8946143CD8819C0Le document en format XML
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Vacca</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="D Alba, Lucia" sort="D Alba, Lucia" uniqKey="D Alba L" first="Lucia" last="D'Alba">Lucia D'Alba</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bracci, Fiammetta" sort="Bracci, Fiammetta" uniqKey="Bracci F" first="Fiammetta" last="Bracci">Fiammetta Bracci</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ruggieri, Stefano" sort="Ruggieri, Stefano" uniqKey="Ruggieri S" first="Stefano" last="Ruggieri">Stefano Ruggieri</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Torti, Margherita" sort="Torti, Margherita" uniqKey="Torti M" first="Margherita" last="Torti">Margherita Torti</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Corazziari, Enrico" sort="Corazziari, Enrico" uniqKey="Corazziari E" first="Enrico" last="Corazziari">Enrico Corazziari</name><affiliation><mods:affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-01">2000-01</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="76">76</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FF7B1906F005DF50C0029B7ED8946143CD8819C0</idno><idno type="DOI">10.1002/1531-8257(200001)15:1<71::AID-MDS1012>3.0.CO;2-W</idno><idno type="ArticleID">MDS1012</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anorectal function</term><term>Constipation</term><term>Manometry</term><term>Multiple system atrophy</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p <0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Fabrizio Stocchi MD, PhD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Danilo Badiali MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Laura Vacca Phd</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Lucia D'Alba MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Fiammetta Bracci MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Stefano Ruggieri MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Margherita Torti MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Berardelli MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item><json:item><name>Enrico Corazziari MD</name><affiliations><json:string>Departments of Neuroscience, University “La Sapienza” Rome, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Anorectal function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Manometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Constipation</value></json:item></subject><language><json:string>eng</json:string></language><abstract>This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p >0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.</abstract><qualityIndicators><score>5.995</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1460</abstractCharCount><pdfWordCount>3319</pdfWordCount><pdfCharCount>21327</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>223</abstractWordCount></qualityIndicators><title>Anorectal function in multiple system atrophy and Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>15</volume><pages><total>6</total><last>76</last><first>71</first></pages><issn><json:string>0885-3185</json:string></issn><issue>1</issue><subject><json:item><value>Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1002/1531-8257(200001)15:1>71::AID-MDS1012>3.0.CO;2-W</json:string></doi><id>FF7B1906F005DF50C0029B7ED8946143CD8819C0</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FF7B1906F005DF50C0029B7ED8946143CD8819C0/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FF7B1906F005DF50C0029B7ED8946143CD8819C0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FF7B1906F005DF50C0029B7ED8946143CD8819C0/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Anorectal function in multiple system atrophy and Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><availability><p>John Wiley & Sons, Inc.</p></availability><date>2000</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Anorectal function in multiple system atrophy and Parkinson's disease</title><author><persName><forename type="first">Fabrizio</forename><surname>Stocchi</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neuroscience, University “La Sapienza,” Viale dell'Università 30, Rome 00185, Italy</p></note><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Danilo</forename><surname>Badiali</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Laura</forename><surname>Vacca</surname><roleName type="degree">Phd</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Lucia</forename><surname>D'Alba</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Fiammetta</forename><surname>Bracci</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Stefano</forename><surname>Ruggieri</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Margherita</forename><surname>Torti</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Alfredo</forename><surname>Berardelli</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author><author><persName><forename type="first">Enrico</forename><surname>Corazziari</surname><roleName type="degree">MD</roleName></persName><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-01"></date><biblScope unit="vol">15</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="76">76</biblScope></imprint></monogr><idno type="istex">FF7B1906F005DF50C0029B7ED8946143CD8819C0</idno><idno type="DOI">10.1002/1531-8257(200001)15:1<71::AID-MDS1012>3.0.CO;2-W</idno><idno type="ArticleID">MDS1012</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p <0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Multiple system atrophy</term></item><item><term>Parkinson's disease</term></item><item><term>Anorectal function</term></item><item><term>Manometry</term></item><item><term>Constipation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-02-05">Received</change><change when="1999-08-18">Registration</change><change when="2000-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FF7B1906F005DF50C0029B7ED8946143CD8819C0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Lucia</givenNames><familyName>D'Alba</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Fiammetta</givenNames><familyName>Bracci</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Stefano</givenNames><familyName>Ruggieri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Margherita</givenNames><familyName>Torti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alfredo</givenNames><familyName>Berardelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Enrico</givenNames><familyName>Corazziari</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Gastroenterology, University “La Sapienza” Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Neuromed, Pozzilli (IS)</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Multiple system atrophy</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">Anorectal function</keyword><keyword xml:id="kwd4">Manometry</keyword><keyword xml:id="kwd5">Constipation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p <0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Anorectal function in multiple system atrophy and Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Anorectal Function in Parkinsonisms</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Anorectal function in multiple system atrophy and Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Fabrizio</namePart><namePart type="family">Stocchi</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><description>Correspondence: Department of Neuroscience, University “La Sapienza,” Viale dell'Università 30, Rome 00185, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danilo</namePart><namePart type="family">Badiali</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Vacca</namePart><namePart type="termsOfAddress">Phd</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucia</namePart><namePart type="family">D'Alba</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fiammetta</namePart><namePart type="family">Bracci</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefano</namePart><namePart type="family">Ruggieri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margherita</namePart><namePart type="family">Torti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfredo</namePart><namePart type="family">Berardelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Enrico</namePart><namePart type="family">Corazziari</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Neuroscience, University “La Sapienza” Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2000-01</dateIssued><dateCaptured encoding="w3cdtf">1999-02-05</dateCaptured><dateValid encoding="w3cdtf">1999-08-18</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">23</extent><extent unit="words">3234</extent></physicalDescription><abstract lang="en">This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with Parkinson's disease (PD) and 16 patients with multiple system atrophy (MSA) underwent anorectal manometry with a continuously perfused multi‐lumen catheter, located to record pressures from the anal canal, and a balloon for rectal distension. Data were analyzed by observers blind to the neurologic diagnosis. Disease duration was shorter in the MSA than in the PD group (6 + 4 versus 10 + 5 yrs, p <0.05). Most patients reported a bowel frequency of less than three evacuations per week and some patients had fecal incontinence. Most manometric recordings disclosed an abnormal pattern during straining (a paradoxic contraction or lack of inhibition) in 13 patients with MSA and 11 patients with PD. Mean anal pressures and rectal sensitivity threshold were not significantly higher in the MSA group, whereas the inhibitory anal reflex and rectal compliance thresholds were within the normal range in both groups. Manometric patterns did not differentiate patients with MSA from patients with PD. Most patients in both groups showed an abnormal straining pattern, decreased anal tone, or both dysfunctions. In conclusion, our findings suggest that although bowel and anorectal dysfunctions do not differentiate MSA from PD, both abnormalities occur earlier and develop faster in MSA than in PD.</abstract><subject lang="en"><genre>Keywords</genre><topic>Multiple system atrophy</topic><topic>Parkinson's disease</topic><topic>Anorectal function</topic><topic>Manometry</topic><topic>Constipation</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>71</start><end>76</end><total>6</total></extent></part></relatedItem><identifier type="istex">FF7B1906F005DF50C0029B7ED8946143CD8819C0</identifier><identifier type="DOI">10.1002/1531-8257(200001)15:1<71::AID-MDS1012>3.0.CO;2-W</identifier><identifier type="ArticleID">MDS1012</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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