Evidence of increased odds of essential tremor in Parkinson's disease
Identifieur interne : 001762 ( Istex/Corpus ); précédent : 001761; suivant : 001763Evidence of increased odds of essential tremor in Parkinson's disease
Auteurs : Eng-King Tan ; Seng-Swim Lee ; Fook-Chong S. ; Sau-Ying LumSource :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
English descriptors
- KwdEn :
Abstract
In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22005
Links to Exploration step
ISTEX:E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of increased odds of essential tremor in Parkinson's disease</title><author><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><mods:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke‐NUS Graduate Medical School, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Lee, Seng Wim" sort="Lee, Seng Wim" uniqKey="Lee S" first="Seng-Swim" last="Lee">Seng-Swim Lee</name><affiliation><mods:affiliation>Department of Medicine, Singapore General Hospital, Singapore</mods:affiliation></affiliation></author><author><name sortKey="S, Fook Hong" sort="S, Fook Hong" uniqKey="S F" first="Fook-Chong" last="S.">Fook-Chong S.</name><affiliation><mods:affiliation>Department of Clinical Research, Singapore General Hospital, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Lum, Sau Ing" sort="Lum, Sau Ing" uniqKey="Lum S" first="Sau-Ying" last="Lum">Sau-Ying Lum</name><affiliation><mods:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22005</idno><idno type="url">https://api.istex.fr/document/E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001762</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Evidence of increased odds of essential tremor in Parkinson's disease</title><author><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><mods:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke‐NUS Graduate Medical School, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Lee, Seng Wim" sort="Lee, Seng Wim" uniqKey="Lee S" first="Seng-Swim" last="Lee">Seng-Swim Lee</name><affiliation><mods:affiliation>Department of Medicine, Singapore General Hospital, Singapore</mods:affiliation></affiliation></author><author><name sortKey="S, Fook Hong" sort="S, Fook Hong" uniqKey="S F" first="Fook-Chong" last="S.">Fook-Chong S.</name><affiliation><mods:affiliation>Department of Clinical Research, Singapore General Hospital, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Lum, Sau Ing" sort="Lum, Sau Ing" uniqKey="Lum S" first="Sau-Ying" last="Lum">Sau-Ying Lum</name><affiliation><mods:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="993">993</biblScope><biblScope unit="page" to="997">997</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</idno><idno type="DOI">10.1002/mds.22005</idno><idno type="ArticleID">MDS22005</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>association</term><term>essential tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Eng‐King Tan MD</name><affiliations><json:string>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</json:string><json:string>Duke‐NUS Graduate Medical School, Singapore</json:string></affiliations></json:item><json:item><name>Seng‐Swim Lee MD</name><affiliations><json:string>Department of Medicine, Singapore General Hospital, Singapore</json:string></affiliations></json:item><json:item><name>Fook‐Chong S. MSc</name><affiliations><json:string>Department of Clinical Research, Singapore General Hospital, Singapore</json:string></affiliations></json:item><json:item><name>Sau‐Ying Lum BSc</name><affiliations><json:string>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>association</value></json:item></subject><language><json:string>eng</json:string></language><abstract>In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P > 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P > 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P > 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P > 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>6.032</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1598</abstractCharCount><pdfWordCount>3032</pdfWordCount><pdfCharCount>17725</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>281</abstractWordCount></qualityIndicators><title>Evidence of increased odds of essential tremor in Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>23</volume><pages><total>5</total><last>997</last><first>993</first></pages><issn><json:string>0885-3185</json:string></issn><issue>7</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.22005</json:string></doi><id>E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Evidence of increased odds of essential tremor in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2008</date></publicationStmt><notesStmt><note>American National Parkinson Foundation International Center of Excellence</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Evidence of increased odds of essential tremor in Parkinson's disease</title><author><persName><forename type="first">Eng‐King</forename><surname>Tan</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Singapore General Hospital, Duke‐NUS Graduate School of Medicine, Outram Road, Singapore 169608</p></note><affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</affiliation><affiliation>Duke‐NUS Graduate Medical School, Singapore</affiliation></author><author><persName><forename type="first">Seng‐Swim</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Medicine, Singapore General Hospital, Singapore</affiliation></author><author><persName><forename type="first">Fook‐Chong</forename><surname>S.</surname><roleName type="degree">MSc</roleName></persName><affiliation>Department of Clinical Research, Singapore General Hospital, Singapore</affiliation></author><author><persName><forename type="first">Sau‐Ying</forename><surname>Lum</surname><roleName type="degree">BSc</roleName></persName><affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15"></date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="993">993</biblScope><biblScope unit="page" to="997">997</biblScope></imprint></monogr><idno type="istex">E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</idno><idno type="DOI">10.1002/mds.22005</idno><idno type="ArticleID">MDS22005</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="fr"><p>In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>essential tremor</term></item><item><term>Parkinson's disease</term></item><item><term>association</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-09-05">Received</change><change when="2008-02-05">Registration</change><change when="2008-05-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi origin="wiley" registered="yes">10.1002/mds.v23:7</doi><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2008-05-15">15 May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22005</doi><idGroup><id type="unit" value="MDS22005"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2007-09-05"></event><event type="manuscriptRevised" date="2008-01-30"></event><event type="manuscriptAccepted" date="2008-02-05"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-03-28"></event><event type="firstOnline" date="2008-03-28"></event><event type="publishedOnlineFinalForm" date="2008-05-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-04-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">993</numbering><numbering type="pageLast">997</numbering></numberingGroup><correspondenceTo>Department of Neurology, Singapore General Hospital, Duke‐NUS Graduate School of Medicine, Outram Road, Singapore 169608</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22005.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="23"></count><count type="wordTotal" number="3414"></count></countGroup><titleGroup><title type="main" xml:lang="en">Evidence of increased odds of essential tremor in Parkinson's disease</title><title type="short" xml:lang="en">Increased Odds of Essential Tremor in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Eng‐King</givenNames><familyName>Tan</familyName><degrees>MD</degrees></personName><contactDetails><email>gnrtek@sgh.com.sg</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Seng‐Swim</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Fook‐Chong</givenNames><familyName>S.</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sau‐Ying</givenNames><familyName>Lum</familyName><degrees>BSc</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="SG" type="organization"><unparsedAffiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="SG" type="organization"><unparsedAffiliation>Duke‐NUS Graduate Medical School, Singapore</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="SG" type="organization"><unparsedAffiliation>Department of Medicine, Singapore General Hospital, Singapore</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="SG" type="organization"><unparsedAffiliation>Department of Clinical Research, Singapore General Hospital, Singapore</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">essential tremor</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">association</keyword></keywordGroup><fundingInfo><fundingAgency>American National Parkinson Foundation International Center of Excellence</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, <i>P</i> < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, <i>P</i> < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (<i>P</i> = 0.004) and healthy controls (0%) (<i>P</i> = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, <i>P</i> < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, <i>P</i> < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Evidence of increased odds of essential tremor in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Increased Odds of Essential Tremor in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Evidence of increased odds of essential tremor in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Eng‐King</namePart><namePart type="family">Tan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</affiliation><affiliation>Duke‐NUS Graduate Medical School, Singapore</affiliation><description>Correspondence: Department of Neurology, Singapore General Hospital, Duke‐NUS Graduate School of Medicine, Outram Road, Singapore 169608</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Seng‐Swim</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Medicine, Singapore General Hospital, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fook‐Chong</namePart><namePart type="family">S.</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Clinical Research, Singapore General Hospital, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sau‐Ying</namePart><namePart type="family">Lum</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-05-15</dateIssued><dateCaptured encoding="w3cdtf">2007-09-05</dateCaptured><dateValid encoding="w3cdtf">2008-02-05</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">23</extent><extent unit="words">3414</extent></physicalDescription><abstract lang="fr">In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</abstract><note type="funding">American National Parkinson Foundation International Center of Excellence</note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>Parkinson's disease</topic><topic>association</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>993</start><end>997</end><total>5</total></extent></part></relatedItem><identifier type="istex">E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</identifier><identifier type="DOI">10.1002/mds.22005</identifier><identifier type="ArticleID">MDS22005</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001762 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001762 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556
|texte= Evidence of increased odds of essential tremor in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |