Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
Identifieur interne : 001517 ( Istex/Corpus ); précédent : 001516; suivant : 001518Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
Auteurs : Emma J. Burton ; Ian G. Mckeith ; David J. Burn ; John T. O'BrienSource :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
English descriptors
- KwdEn :
Abstract
Increased rates of brain atrophy are seen in Alzheimer's disease, but whether rates are similarly increased in other dementias such as Parkinson's disease dementia (PDD) has not been well examined. We determined the rates of brain atrophy using serial magnetic resonance imaging (MRI) in PDD and compared this finding to rates seen in cognitively intact Parkinson's disease (PD) patients and age‐matched control subjects. Thirty‐one patients (PD = 18, PDD = 13) and 24 age‐matched controls underwent serial volumetric 1.5 T MRI scans, approximately 1 year apart. Baseline and repeat scans were registered and quantification of the brain boundary shift integral was used to determine whole‐brain atrophy rates. Rates of brain atrophy were significantly increased in PDD (1.12 ± 0.98%/year) compared to PD (0.31 ± 0.69%/year; P = 0.018) and control subjects (0.34 ± 0.76%/year; P = 0.015). There were no differences in atrophy rates between controls and PD (P = 0.79). No correlations between increased atrophy rates and age or dementia severity (Mini‐Mental State Examination score) were observed. Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20652
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ISTEX:2C6F45263D238D81F41B33225A241B7DC55D9D17Le document en format XML
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Thirty‐one patients (PD = 18, PDD = 13) and 24 age‐matched controls underwent serial volumetric 1.5 T MRI scans, approximately 1 year apart. Baseline and repeat scans were registered and quantification of the brain boundary shift integral was used to determine whole‐brain atrophy rates. Rates of brain atrophy were significantly increased in PDD (1.12 ± 0.98%/year) compared to PD (0.31 ± 0.69%/year; P = 0.018) and control subjects (0.34 ± 0.76%/year; P = 0.015). There were no differences in atrophy rates between controls and PD (P = 0.79). No correlations between increased atrophy rates and age or dementia severity (Mini‐Mental State Examination score) were observed. 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Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis. © 2005 Movement Disorder Society</abstract><note type="funding">MRC</note><subject lang="en"><genre>Keywords</genre><topic>serial MRI</topic><topic>Parkinson's disease dementia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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|clé= ISTEX:2C6F45263D238D81F41B33225A241B7DC55D9D17
|texte= Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
}}
| This area was generated with Dilib version V0.6.23. |  |