Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease
Identifieur interne : 001516 ( Istex/Corpus ); précédent : 001515; suivant : 001517Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease
Auteurs : Kyum-Yil Kwon ; Choong G. Choi ; Jae S. Kim ; Myoung C. Lee ; Sun J. ChungSource :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
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Abstract
To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21714
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Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Kyum‐Yil Kwon MD</name><affiliations><json:string>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Choong G. Choi MD</name><affiliations><json:string>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Jae S. Kim MD</name><affiliations><json:string>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Myoung C. Lee MD</name><affiliations><json:string>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Sun J. 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Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>multiple system atrophy</term></item><item><term>Parkinson's disease</term></item><item><term>MRI</term></item><item><term>18F‐FDG PET</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-06-01">Received</change><change when="2007-07-25">Registration</change><change when="2007-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/6C19A58595B60C7ABE9642D438D05CFF277BDA8E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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href="file:MDS.MDS21714.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="4629"></count></countGroup><titleGroup><title type="main" xml:lang="en">Comparison of brain MRI and <sup>18</sup>F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease</title><title type="short" xml:lang="en">Diagnostic Value of Brain MRI and <sup>18</sup>F‐FDG PET</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kyum‐Yil</givenNames><familyName>Kwon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Choong G.</givenNames><familyName>Choi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jae S.</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Myoung C.</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Sun J.</givenNames><familyName>Chung</familyName><degrees>MD</degrees></personName><contactDetails><email>sjchung@amc.seoul.kr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KR" type="organization"><unparsedAffiliation>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="KR" type="organization"><unparsedAffiliation>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">multiple system atrophy</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">MRI</keyword><keyword xml:id="kwd4"><sup>18</sup>F‐FDG PET</keyword></keywordGroup><fundingInfo><fundingAgency>Asan Institute for Life Sciences, Seoul, Korea</fundingAgency><fundingNumber>2007‐416</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>To investigate the diagnostic value of brain magnetic resonance image (MRI) and <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography (<sup>18</sup>F‐FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual <sup>18</sup>F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of <sup>18</sup>F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of <sup>18</sup>F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and <sup>18</sup>F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that <sup>18</sup>F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Diagnostic Value of Brain MRI and 18F‐FDG PET</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparison of brain MRI and</title></titleInfo><name type="personal"><namePart type="given">Kyum‐Yil</namePart><namePart type="family">Kwon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Choong G.</namePart><namePart type="family">Choi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jae S.</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Myoung C.</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sun J.</namePart><namePart type="family">Chung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><description>Correspondence: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388‐1, Poongnap‐dong, Songpa‐gu, Seoul 138‐736, South Korea</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-12-15</dateIssued><dateCaptured encoding="w3cdtf">2007-06-01</dateCaptured><dateValid encoding="w3cdtf">2007-07-25</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">30</extent><extent unit="words">4629</extent></physicalDescription><abstract lang="en">To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society</abstract><note type="funding">Asan Institute for Life Sciences, Seoul, Korea - No. 2007‐416; </note><subject lang="en"><genre>Keywords</genre><topic>multiple system atrophy</topic><topic>Parkinson's disease</topic><topic>MRI</topic><topic>18F‐FDG PET</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2352</start><end>2358</end><total>7</total></extent></part></relatedItem><identifier type="istex">6C19A58595B60C7ABE9642D438D05CFF277BDA8E</identifier><identifier type="DOI">10.1002/mds.21714</identifier><identifier type="ArticleID">MDS21714</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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