Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease
Identifieur interne : 001116 ( Istex/Corpus ); précédent : 001115; suivant : 001117Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease
Auteurs : Natalie E. Allen ; Colleen G. Canning ; Catherine Sherrington ; Victor S. C. FungSource :
- Movement Disorders [ 0885-3185 ] ; 2009-07-15.
English descriptors
Abstract
Muscle power (force × velocity) could clarify the relationship between weakness and bradykinesia in Parkinson's disease (PD). The aims of this study were to determine if patients with PD were weaker and/or less powerful in their leg extensor muscles than a neurologically normal control group and to determine the relative contributions of force and movement velocity/bradykinesia to muscle power in PD. Forty patients with PD and 40 controls were assessed. Strength in Newtons (N) was measured as the heaviest load the participant could lift. Power in Watts (W) was measured by having the participant perform lifts as fast as possible. The PD group were 172 N weaker (95% CI 28–315) and 124 W less powerful at peak power (95% CI 32–216) than controls. However, velocity at maximal power was only reduced compared with controls when lifting light to medium loads. When lifting heavy loads bradykinesia was no longer apparent in the PD group. These results suggest that reduced muscle power in PD at lighter loads arises from weakness and bradykinesia combined, but at heavier loads arises only from weakness. The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22609
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ISTEX:A3C314E769869CF32AB507EE972B6CD6705FBFC3Le document en format XML
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Allen</name><affiliation><mods:affiliation>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Canning, Colleen G" sort="Canning, Colleen G" uniqKey="Canning C" first="Colleen G." last="Canning">Colleen G. Canning</name><affiliation><mods:affiliation>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sherrington, Catherine" sort="Sherrington, Catherine" uniqKey="Sherrington C" first="Catherine" last="Sherrington">Catherine Sherrington</name><affiliation><mods:affiliation>The George Institute for International Health, The University of Sydney, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Fung, Victor S C" sort="Fung, Victor S C" uniqKey="Fung V" first="Victor S. C." last="Fung">Victor S. C. 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The aims of this study were to determine if patients with PD were weaker and/or less powerful in their leg extensor muscles than a neurologically normal control group and to determine the relative contributions of force and movement velocity/bradykinesia to muscle power in PD. Forty patients with PD and 40 controls were assessed. Strength in Newtons (N) was measured as the heaviest load the participant could lift. Power in Watts (W) was measured by having the participant perform lifts as fast as possible. The PD group were 172 N weaker (95% CI 28–315) and 124 W less powerful at peak power (95% CI 32–216) than controls. However, velocity at maximal power was only reduced compared with controls when lifting light to medium loads. When lifting heavy loads bradykinesia was no longer apparent in the PD group. These results suggest that reduced muscle power in PD at lighter loads arises from weakness and bradykinesia combined, but at heavier loads arises only from weakness. The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Natalie E. Allen BAppSc (Physio) Hons</name><affiliations><json:string>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</json:string></affiliations></json:item><json:item><name>Colleen G. Canning BPhty, MA, PhD</name><affiliations><json:string>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</json:string></affiliations></json:item><json:item><name>Catherine Sherrington BAppSc (Physio), MPH, PhD</name><affiliations><json:string>The George Institute for International Health, The University of Sydney, Sydney, Australia</json:string></affiliations></json:item><json:item><name>Victor S.C. Fung MB, BS, PhD, FRACP</name><affiliations><json:string>Movement Disorder Unit, Department of Neurology, Westmead Hospital, Sydney, Australia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bradykinesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>muscle weakness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>muscle power</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Muscle power (force × velocity) could clarify the relationship between weakness and bradykinesia in Parkinson's disease (PD). The aims of this study were to determine if patients with PD were weaker and/or less powerful in their leg extensor muscles than a neurologically normal control group and to determine the relative contributions of force and movement velocity/bradykinesia to muscle power in PD. Forty patients with PD and 40 controls were assessed. Strength in Newtons (N) was measured as the heaviest load the participant could lift. Power in Watts (W) was measured by having the participant perform lifts as fast as possible. The PD group were 172 N weaker (95% CI 28–315) and 124 W less powerful at peak power (95% CI 32–216) than controls. However, velocity at maximal power was only reduced compared with controls when lifting light to medium loads. When lifting heavy loads bradykinesia was no longer apparent in the PD group. These results suggest that reduced muscle power in PD at lighter loads arises from weakness and bradykinesia combined, but at heavier loads arises only from weakness. 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type="manuscriptAccepted" date="2009-03-20"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-05-07"></event><event type="firstOnline" date="2009-05-07"></event><event type="publishedOnlineFinalForm" date="2009-07-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1344</numbering><numbering type="pageLast">1351</numbering></numberingGroup><correspondenceTo>Movement Disorder Unit, Department of Neurology, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145, Australia</correspondenceTo><linkGroup><link type="toTypesetVersion" 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type="organization"><unparsedAffiliation>Movement Disorder Unit, Department of Neurology, Westmead Hospital, Sydney, Australia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">bradykinesia</keyword><keyword xml:id="kwd3">muscle weakness</keyword><keyword xml:id="kwd4">muscle power</keyword></keywordGroup><fundingInfo><fundingAgency>University of Sydney Research and Development Scheme</fundingAgency><fundingNumber>S3091U4500</fundingNumber></fundingInfo><fundingInfo><fundingAgency>The University of Sydney Faculty of Health Sciences Postgraduate Research</fundingAgency></fundingInfo><fundingInfo><fundingAgency>George Burniston‐Cumberland Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Health and Medical Research Council Grant</fundingAgency></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22609:MDS_22609_sm_SuppFig1"></mediaResource><caption>Supporting Information Figure 1. Keiser leg press machine used for testing leg muscle strength and power, showing testing (A) starting and (B) finishing position.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22609:MDS_22609_sm_SuppMaterials"></mediaResource><caption>Supporting Information Materials.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Muscle power (force × velocity) could clarify the relationship between weakness and bradykinesia in Parkinson's disease (PD). The aims of this study were to determine if patients with PD were weaker and/or less powerful in their leg extensor muscles than a neurologically normal control group and to determine the relative contributions of force and movement velocity/bradykinesia to muscle power in PD. Forty patients with PD and 40 controls were assessed. Strength in Newtons (N) was measured as the heaviest load the participant could lift. Power in Watts (W) was measured by having the participant perform lifts as fast as possible. The PD group were 172 N weaker (95% CI 28–315) and 124 W less powerful at peak power (95% CI 32–216) than controls. However, velocity at maximal power was only reduced compared with controls when lifting light to medium loads. When lifting heavy loads bradykinesia was no longer apparent in the PD group. These results suggest that reduced muscle power in PD at lighter loads arises from weakness and bradykinesia combined, but at heavier loads arises only from weakness. The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Bradykinesia, Weakness, and Power in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Natalie E.</namePart><namePart type="family">Allen</namePart><namePart type="termsOfAddress">BAppSc (Physio) Hons</namePart><affiliation>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Colleen G.</namePart><namePart type="family">Canning</namePart><namePart type="termsOfAddress">BPhty, MA, PhD</namePart><affiliation>Neurological Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Sherrington</namePart><namePart type="termsOfAddress">BAppSc (Physio), MPH, PhD</namePart><affiliation>The George Institute for International Health, The University of Sydney, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Victor S.C.</namePart><namePart type="family">Fung</namePart><namePart type="termsOfAddress">MB, BS, PhD, FRACP</namePart><affiliation>Movement Disorder Unit, Department of Neurology, Westmead Hospital, Sydney, Australia</affiliation><description>Correspondence: Movement Disorder Unit, Department of Neurology, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145, Australia</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-07-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-22</dateCaptured><dateValid encoding="w3cdtf">2009-03-20</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">2</extent><extent unit="references">32</extent><extent unit="words">4887</extent></physicalDescription><abstract lang="en">Muscle power (force × velocity) could clarify the relationship between weakness and bradykinesia in Parkinson's disease (PD). The aims of this study were to determine if patients with PD were weaker and/or less powerful in their leg extensor muscles than a neurologically normal control group and to determine the relative contributions of force and movement velocity/bradykinesia to muscle power in PD. Forty patients with PD and 40 controls were assessed. Strength in Newtons (N) was measured as the heaviest load the participant could lift. Power in Watts (W) was measured by having the participant perform lifts as fast as possible. The PD group were 172 N weaker (95% CI 28–315) and 124 W less powerful at peak power (95% CI 32–216) than controls. However, velocity at maximal power was only reduced compared with controls when lifting light to medium loads. When lifting heavy loads bradykinesia was no longer apparent in the PD group. These results suggest that reduced muscle power in PD at lighter loads arises from weakness and bradykinesia combined, but at heavier loads arises only from weakness. The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">University of Sydney Research and Development Scheme - No. S3091U4500; </note><note type="funding">The University of Sydney Faculty of Health Sciences Postgraduate Research</note><note type="funding">George Burniston‐Cumberland Foundation</note><note type="funding">National Health and Medical Research Council Grant</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>bradykinesia</topic><topic>muscle weakness</topic><topic>muscle power</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information Figure 1. Keiser leg press machine used for testing leg muscle strength and power, showing testing (A) starting and (B) finishing position. - Supporting Information Materials. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1344</start><end>1351</end><total>8</total></extent></part></relatedItem><identifier type="istex">A3C314E769869CF32AB507EE972B6CD6705FBFC3</identifier><identifier type="DOI">10.1002/mds.22609</identifier><identifier type="ArticleID">MDS22609</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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