Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs
Identifieur interne : 000E56 ( Istex/Corpus ); précédent : 000E55; suivant : 000E57Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs
Auteurs : Susanne A. Schneider ; Vrajesh Udani ; Charulata Sawant Sankhla ; Kailash P. BhatiaSource :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
English descriptors
- KwdEn :
Abstract
Adverse events of dopamine‐blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re‐exposure to the drug. Thus, complete withdrawal is recommended. Recurrent episodes of acute dystonia despite withdrawal and the lack of further exposure to antidopaminergic agents are usually not seen. Here, we report three cases with recurrent OGCs despite complete withdrawal of neuroleptics. Triggering or priming factors were a single dose of haloperidol in two cases and a single dose of metoclopramide in one case. Episodes reoccurred spontaneously, but responded to anticholinergics. The pathomechanisms of acute dystonic reactions and OGCs remain unclear. Parallels to levodopa‐induced dyskinesias in Parkinson's disease, as well as to dopa‐responsive dystonia, paroxysmal dyskinesias, and channelopathies are discussed here. Whether there is a genetic susceptibility or some other reason for only some patients developing this phenomenon remains unclear. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22532
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<affiliation>Department of Pediatrics and Neurology, PD Hinduja National Hospital and Medical Research Center, Veer Savarkar Marg, Mumbai, India</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Charulata Sawant</namePart>
<namePart type="family">Sankhla</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Pediatrics and Neurology, PD Hinduja National Hospital and Medical Research Center, Veer Savarkar Marg, Mumbai, India</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Kailash P.</namePart>
<namePart type="family">Bhatia</namePart>
<namePart type="termsOfAddress">MD, FRCP</namePart>
<affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation>
<description>Correspondence: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre authority="originalCategForm">article</genre>
<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2009-06-15</dateIssued>
<dateCaptured encoding="w3cdtf">2008-11-24</dateCaptured>
<dateValid encoding="w3cdtf">2009-02-13</dateValid>
<copyrightDate encoding="w3cdtf">2009</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
<extent unit="references">19</extent>
<extent unit="words">2377</extent>
</physicalDescription>
<abstract lang="en">Adverse events of dopamine‐blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re‐exposure to the drug. Thus, complete withdrawal is recommended. Recurrent episodes of acute dystonia despite withdrawal and the lack of further exposure to antidopaminergic agents are usually not seen. Here, we report three cases with recurrent OGCs despite complete withdrawal of neuroleptics. Triggering or priming factors were a single dose of haloperidol in two cases and a single dose of metoclopramide in one case. Episodes reoccurred spontaneously, but responded to anticholinergics. The pathomechanisms of acute dystonic reactions and OGCs remain unclear. Parallels to levodopa‐induced dyskinesias in Parkinson's disease, as well as to dopa‐responsive dystonia, paroxysmal dyskinesias, and channelopathies are discussed here. Whether there is a genetic susceptibility or some other reason for only some patients developing this phenomenon remains unclear. © 2009 Movement Disorder Society</abstract>
<note type="content">*Potential conflict of interest: None reported.</note>
<note type="funding">Brain Research Trust, UK</note>
<subject lang="en"><genre>Keywords</genre>
<topic>oculogyric crisis</topic>
<topic>acute dystonic reaction</topic>
<topic>dystonia</topic>
<topic>neuroleptics</topic>
<topic>antidopaminergic treatment</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Video - </note>
<subject><genre>article category</genre>
<topic>Brief Report</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>24</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>8</number>
</detail>
<extent unit="pages"><start>1226</start>
<end>1229</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">F8EDE61931B7C100D8C289490EDA4EEB8B244F4B</identifier>
<identifier type="DOI">10.1002/mds.22532</identifier>
<identifier type="ArticleID">MDS22532</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
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