Cognitive impairment in nondemented Parkinson's disease
Identifieur interne : 000E55 ( Istex/Corpus ); précédent : 000E54; suivant : 000E56Cognitive impairment in nondemented Parkinson's disease
Auteurs : Paolo Barone ; Dag Aarsland ; David Burn ; Murat Emre ; Jaime Kulisevsky ; Daniel WeintraubSource :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
English descriptors
Abstract
A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23919
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<notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Paolo Barone has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Dag Aarsland has received honoraria and research support from Merck Serono. David Burn has previously received honoraria from Merck Serono for acting in a medical advisory capacity. Murat Emre has previously received honoraria from Merck Serono for acting in a medical advisory capacity and for lectures. Jaime Kulisevsky has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Daniel Weintraub has previously received honoraria from Merck Serono for acting in a medical advisory capacity.</note>
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<p>A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management. © 2011 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b>
Paolo Barone has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Dag Aarsland has received honoraria and research support from Merck Serono. David Burn has previously received honoraria from Merck Serono for acting in a medical advisory capacity. Murat Emre has previously received honoraria from Merck Serono for acting in a medical advisory capacity and for lectures. Jaime Kulisevsky has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Daniel Weintraub has previously received honoraria from Merck Serono for acting in a medical advisory capacity.</p>
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<note xml:id="fn2"><p>Full financial disclosures and author roles may be found in the online version of this article.</p>
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<!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Cognitive impairment in nondemented Parkinson's disease</title>
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<titleInfo type="abbreviated" lang="en"><title>Cognitive Impairment in Parkinson's Disease</title>
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<name type="personal"><namePart type="given">Paolo</namePart>
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<affiliation>Department of Neurological Sciences, University Federico II‐ICD Hermitage, Capodimonte, Naples, Italy, and Schola Medica Salernitana, University of Salerno, Italy</affiliation>
<description>Correspondence: Università Federico II, Dipartimento di Scienze Neurologiche, Via Pansini 5, Naples, 80131, Italy</description>
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<name type="personal"><namePart type="given">Dag</namePart>
<namePart type="family">Aarsland</namePart>
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<affiliation>Psychiatric Division, Stavanger University Hospital and Akerhus University Hospital, University of Oslo, Stavanger, Norway</affiliation>
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<name type="personal"><namePart type="given">David</namePart>
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<affiliation>Institute for Ageing and Health, Newcastle University, United Kingdom</affiliation>
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<name type="personal"><namePart type="given">Murat</namePart>
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<affiliation>Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey</affiliation>
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<name type="personal"><namePart type="given">Jaime</namePart>
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<affiliation>Neurology Department, Hospital de Sant Pau (IIB Sant Pau), CIBERNED and Autonomous University of Barcelona, Barcelona, Spain</affiliation>
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<name type="personal"><namePart type="given">Daniel</namePart>
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<affiliation>Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA</affiliation>
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<abstract lang="en">A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management. © 2011 Movement Disorder Society</abstract>
<note type="content">*Relevant conflicts of interest/financial disclosures: Paolo Barone has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Dag Aarsland has received honoraria and research support from Merck Serono. David Burn has previously received honoraria from Merck Serono for acting in a medical advisory capacity. Murat Emre has previously received honoraria from Merck Serono for acting in a medical advisory capacity and for lectures. Jaime Kulisevsky has previously received honoraria from Merck Serono for lectures and acting in a medical advisory capacity. Daniel Weintraub has previously received honoraria from Merck Serono for acting in a medical advisory capacity.</note>
<note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>CIND‐PD</topic>
<topic>mild cognitive impairment</topic>
<topic>symptoms</topic>
<topic>assessment</topic>
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<identifier type="ISSN">0885-3185</identifier>
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<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<part><date>2011</date>
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<number>26</number>
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