Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Identifieur interne : 000C09 ( Istex/Corpus ); précédent : 000C08; suivant : 000C10Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Auteurs : Christopher G. Goetz ; Glenn T. Stebbins ; David Wolff ; William Deleeuw ; Helen Bronte-Stewart ; Rodger Elble ; Mark Hallett ; John Nutt ; Lorraine Ramig ; Terence Sanger ; Allan D. Wu ; Peter H. Kraus ; Lucia M. Blasucci ; Ejaz A. Shamim ; Kapil D. Sethi ; Jennifer Spielman ; Ken Kubota ; Andrew S. Grove ; Eric Dishman ; C. Barr TaylorSource :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
English descriptors
Abstract
We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22379
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Stebbins</name><affiliation><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Deleeuw, William" sort="Deleeuw, William" uniqKey="Deleeuw W" first="William" last="Deleeuw">William Deleeuw</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><affiliation><mods:affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><affiliation><mods:affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</mods:affiliation></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health Sciences University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name><affiliation><mods:affiliation>Speech, Language, and Hearing Science, University of Colorado, Boulder, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>National Center for Voice and Speech, Denver, Colorado, USA</mods:affiliation></affiliation></author><author><name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name><affiliation><mods:affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. 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Shamim</name><affiliation><mods:affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Georgetown University Hospital, Washington DC, USA</mods:affiliation></affiliation></author><author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D." last="Sethi">Kapil D. Sethi</name><affiliation><mods:affiliation>Medical College of Georgia, Augusta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name><affiliation><mods:affiliation>National Center for Voice and Speech, Denver, Colorado, USA</mods:affiliation></affiliation></author><author><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Grove, Andrew S" sort="Grove, Andrew S" uniqKey="Grove A" first="Andrew S." last="Grove">Andrew S. Grove</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C. Barr" last="Taylor">C. Barr Taylor</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:909FDE21B6C19AF13F9C08E1C3796068E9748DB3</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22379</idno><idno type="url">https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name><affiliation><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Deleeuw, William" sort="Deleeuw, William" uniqKey="Deleeuw W" first="William" last="Deleeuw">William Deleeuw</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><affiliation><mods:affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><affiliation><mods:affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</mods:affiliation></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health Sciences University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name><affiliation><mods:affiliation>Speech, Language, and Hearing Science, University of Colorado, Boulder, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>National Center for Voice and Speech, Denver, Colorado, USA</mods:affiliation></affiliation></author><author><name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name><affiliation><mods:affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name><affiliation><mods:affiliation>Department of Neurology, University of California, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name><affiliation><mods:affiliation>Department of Neurology, Univerität Bochum, Bochum, Germany</mods:affiliation></affiliation></author><author><name sortKey="Blasucci, Lucia M" sort="Blasucci, Lucia M" uniqKey="Blasucci L" first="Lucia M." last="Blasucci">Lucia M. Blasucci</name><affiliation><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><affiliation><mods:affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Georgetown University Hospital, Washington DC, USA</mods:affiliation></affiliation></author><author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D." last="Sethi">Kapil D. Sethi</name><affiliation><mods:affiliation>Medical College of Georgia, Augusta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name><affiliation><mods:affiliation>National Center for Voice and Speech, Denver, Colorado, USA</mods:affiliation></affiliation></author><author><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Grove, Andrew S" sort="Grove, Andrew S" uniqKey="Grove A" first="Andrew S." last="Grove">Andrew S. Grove</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name><affiliation><mods:affiliation>Intel Corporation, Santa Clara, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C. Barr" last="Taylor">C. Barr Taylor</name><affiliation><mods:affiliation>Kinetics Foundation, Los Altos, California, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="551">551</biblScope><biblScope unit="page" to="556">556</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">909FDE21B6C19AF13F9C08E1C3796068E9748DB3</idno><idno type="DOI">10.1002/mds.22379</idno><idno type="ArticleID">MDS22379</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>accelerometer</term><term>bradykinesia</term><term>computer‐based technology</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Christopher G. Goetz MD</name><affiliations><json:string>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Glenn T. Stebbins PhD</name><affiliations><json:string>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>David Wolff BS</name><affiliations><json:string>Kinetics Foundation, Los Altos, California, USA</json:string></affiliations></json:item><json:item><name>William DeLeeuw BSEE</name><affiliations><json:string>Intel Corporation, Santa Clara, California, USA</json:string></affiliations></json:item><json:item><name>Helen Bronte‐Stewart MD, MSE</name><affiliations><json:string>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</json:string></affiliations></json:item><json:item><name>Rodger Elble MD, PhD</name><affiliations><json:string>Department of Neurology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA</json:string></affiliations></json:item><json:item><name>Mark Hallett MD</name><affiliations><json:string>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</json:string></affiliations></json:item><json:item><name>John Nutt MD</name><affiliations><json:string>Department of Neurology, Oregon Health Sciences University, Portland, Oregon, USA</json:string></affiliations></json:item><json:item><name>Lorraine Ramig PhD</name><affiliations><json:string>Speech, Language, and Hearing Science, University of Colorado, Boulder, Colorado, USA</json:string><json:string>National Center for Voice and Speech, Denver, Colorado, USA</json:string></affiliations></json:item><json:item><name>Terence Sanger MD, PhD</name><affiliations><json:string>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</json:string></affiliations></json:item><json:item><name>Allan D. Wu MD</name><affiliations><json:string>Department of Neurology, University of California, Los Angeles, California, USA</json:string></affiliations></json:item><json:item><name>Peter H. Kraus MD</name><affiliations><json:string>Department of Neurology, Univerität Bochum, Bochum, Germany</json:string></affiliations></json:item><json:item><name>Lucia M. Blasucci RN</name><affiliations><json:string>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Ejaz A. Shamim MD, MS</name><affiliations><json:string>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</json:string><json:string>Department of Neurology, Georgetown University Hospital, Washington DC, USA</json:string></affiliations></json:item><json:item><name>Kapil D. Sethi MD</name><affiliations><json:string>Medical College of Georgia, Augusta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Jennifer Spielman MA</name><affiliations><json:string>National Center for Voice and Speech, Denver, Colorado, USA</json:string></affiliations></json:item><json:item><name>Ken Kubota BS</name><affiliations><json:string>Kinetics Foundation, Los Altos, California, USA</json:string></affiliations></json:item><json:item><name>Andrew S. Grove PhD</name><affiliations><json:string>Intel Corporation, Santa Clara, California, USA</json:string></affiliations></json:item><json:item><name>Eric Dishman MS</name><affiliations><json:string>Intel Corporation, Santa Clara, California, USA</json:string></affiliations></json:item><json:item><name>C. Barr Taylor MD</name><affiliations><json:string>Kinetics Foundation, Los Altos, California, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bradykinesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>computer‐based technology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>accelerometer</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>6.885</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1711</abstractCharCount><pdfWordCount>3885</pdfWordCount><pdfCharCount>24364</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>260</abstractWordCount></qualityIndicators><title>Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>6</total><last>556</last><first>551</first></pages><issn><json:string>0885-3185</json:string></issn><issue>4</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22379</json:string></doi><id>909FDE21B6C19AF13F9C08E1C3796068E9748DB3</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>Kinetics Foundation. Intel Inc.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title><author><persName><forename type="first">Christopher G.</forename><surname>Goetz</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: 1725 W. Harrison Street, Suite 755, Chicago, IL 60612</p></note><affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">Glenn T.</forename><surname>Stebbins</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">David</forename><surname>Wolff</surname><roleName type="degree">BS</roleName></persName><affiliation>Kinetics Foundation, Los Altos, California, USA</affiliation></author><author><persName><forename type="first">William</forename><surname>DeLeeuw</surname><roleName type="degree">BSEE</roleName></persName><affiliation>Intel Corporation, Santa Clara, California, USA</affiliation></author><author><persName><forename type="first">Helen</forename><surname>Bronte‐Stewart</surname><roleName type="degree">MD, MSE</roleName></persName><affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</affiliation></author><author><persName><forename type="first">Rodger</forename><surname>Elble</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA</affiliation></author><author><persName><forename type="first">Mark</forename><surname>Hallett</surname><roleName type="degree">MD</roleName></persName><affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</affiliation></author><author><persName><forename type="first">John</forename><surname>Nutt</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Oregon Health Sciences University, Portland, Oregon, USA</affiliation></author><author><persName><forename type="first">Lorraine</forename><surname>Ramig</surname><roleName type="degree">PhD</roleName></persName><affiliation>Speech, Language, and Hearing Science, University of Colorado, Boulder, Colorado, USA</affiliation><affiliation>National Center for Voice and Speech, Denver, Colorado, USA</affiliation></author><author><persName><forename type="first">Terence</forename><surname>Sanger</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California, USA</affiliation></author><author><persName><forename type="first">Allan D.</forename><surname>Wu</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of California, Los Angeles, California, USA</affiliation></author><author><persName><forename type="first">Peter H.</forename><surname>Kraus</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Univerität Bochum, Bochum, Germany</affiliation></author><author><persName><forename type="first">Lucia M.</forename><surname>Blasucci</surname><roleName type="degree">RN</roleName></persName><affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">Ejaz A.</forename><surname>Shamim</surname><roleName type="degree">MD, MS</roleName></persName><affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</affiliation><affiliation>Department of Neurology, Georgetown University Hospital, Washington DC, USA</affiliation></author><author><persName><forename type="first">Kapil D.</forename><surname>Sethi</surname><roleName type="degree">MD</roleName></persName><affiliation>Medical College of Georgia, Augusta, Georgia, USA</affiliation></author><author><persName><forename type="first">Jennifer</forename><surname>Spielman</surname><roleName type="degree">MA</roleName></persName><affiliation>National Center for Voice and Speech, Denver, Colorado, USA</affiliation></author><author><persName><forename type="first">Ken</forename><surname>Kubota</surname><roleName type="degree">BS</roleName></persName><affiliation>Kinetics Foundation, Los Altos, California, USA</affiliation></author><author><persName><forename type="first">Andrew S.</forename><surname>Grove</surname><roleName type="degree">PhD</roleName></persName><affiliation>Intel Corporation, Santa Clara, California, USA</affiliation></author><author><persName><forename type="first">Eric</forename><surname>Dishman</surname><roleName type="degree">MS</roleName></persName><affiliation>Intel Corporation, Santa Clara, California, USA</affiliation></author><author><persName><forename type="first">C. Barr</forename><surname>Taylor</surname><roleName type="degree">MD</roleName></persName><affiliation>Kinetics Foundation, Los Altos, California, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15"></date><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="551">551</biblScope><biblScope unit="page" to="556">556</biblScope></imprint></monogr><idno type="istex">909FDE21B6C19AF13F9C08E1C3796068E9748DB3</idno><idno type="DOI">10.1002/mds.22379</idno><idno type="ArticleID">MDS22379</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>tremor</term></item><item><term>bradykinesia</term></item><item><term>computer‐based technology</term></item><item><term>accelerometer</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-07-31">Received</change><change when="2008-10-01">Registration</change><change when="2009-03-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Intel Inc.</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (<i>P</i> = 0.08), tremor (<i>P</i> = 0.06) and speech (<i>P</i> = 0.11). Change in tremor was a significant predictor of change in UPDRS (<i>P</i> = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Feasibility Study of an At‐Home Testing Device</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device</title></titleInfo><name type="personal"><namePart type="given">Christopher G.</namePart><namePart type="family">Goetz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</affiliation><description>Correspondence: 1725 W. 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Disorder Center, Stanford University, Palo Alto, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Allan D.</namePart><namePart type="family">Wu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of California, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter H.</namePart><namePart type="family">Kraus</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Univerität Bochum, Bochum, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucia M.</namePart><namePart type="family">Blasucci</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ejaz A.</namePart><namePart type="family">Shamim</namePart><namePart type="termsOfAddress">MD, MS</namePart><affiliation>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland, USA</affiliation><affiliation>Department of Neurology, Georgetown University Hospital, Washington DC, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kapil D.</namePart><namePart type="family">Sethi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Medical College of Georgia, Augusta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer</namePart><namePart type="family">Spielman</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>National Center for Voice and Speech, Denver, Colorado, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ken</namePart><namePart type="family">Kubota</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Kinetics Foundation, Los Altos, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew S.</namePart><namePart type="family">Grove</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Intel Corporation, Santa Clara, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric</namePart><namePart type="family">Dishman</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Intel Corporation, Santa Clara, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Barr</namePart><namePart type="family">Taylor</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Kinetics Foundation, Los Altos, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-03-15</dateIssued><dateCaptured encoding="w3cdtf">2008-07-31</dateCaptured><dateValid encoding="w3cdtf">2008-10-01</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">14</extent><extent unit="words">4521</extent></physicalDescription><abstract lang="en">We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Kinetics Foundation. Intel Inc.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>tremor</topic><topic>bradykinesia</topic><topic>computer‐based technology</topic><topic>accelerometer</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>551</start><end>556</end><total>6</total></extent></part></relatedItem><identifier type="istex">909FDE21B6C19AF13F9C08E1C3796068E9748DB3</identifier><identifier type="DOI">10.1002/mds.22379</identifier><identifier type="ArticleID">MDS22379</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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