Positive family history of essential tremor influences the motor phenotype of Parkinson's disease
Identifieur interne : 000A85 ( Istex/Corpus ); précédent : 000A84; suivant : 000A86Positive family history of essential tremor influences the motor phenotype of Parkinson's disease
Auteurs : Peter Hedera ; John Y. Fang ; Fenna Phibbs ; Michael K. Cooper ; P. David Charles ; Thomas L. DavisSource :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
English descriptors
Abstract
Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22772
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ISTEX:EF6CCAF1C41641351C7EB3AB11098051998933C0Le document en format XML
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Fang</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Phibbs, Fenna" sort="Phibbs, Fenna" uniqKey="Phibbs F" first="Fenna" last="Phibbs">Fenna Phibbs</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Cooper, Michael K" sort="Cooper, Michael K" uniqKey="Cooper M" first="Michael K." last="Cooper">Michael K. Cooper</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Charles, P David" sort="Charles, P David" uniqKey="Charles P" first="P. David" last="Charles">P. 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Fang</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Phibbs, Fenna" sort="Phibbs, Fenna" uniqKey="Phibbs F" first="Fenna" last="Phibbs">Fenna Phibbs</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Cooper, Michael K" sort="Cooper, Michael K" uniqKey="Cooper M" first="Michael K." last="Cooper">Michael K. Cooper</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Charles, P David" sort="Charles, P David" uniqKey="Charles P" first="P. David" last="Charles">P. David Charles</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author><author><name sortKey="Davis, Thomas L" sort="Davis, Thomas L" uniqKey="Davis T" first="Thomas L." last="Davis">Thomas L. Davis</name><affiliation><mods:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Peter Hedera MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string><json:string>Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item><json:item><name>John Y. Fang MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item><json:item><name>Fenna Phibbs MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item><json:item><name>Michael K. Cooper MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item><json:item><name>P. David Charles MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item><json:item><name>Thomas L. Davis MD</name><affiliations><json:string>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autosomal dominant inheritance</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P > 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>6.98</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1029</abstractCharCount><pdfWordCount>7688</pdfWordCount><pdfCharCount>48676</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>165</abstractWordCount></qualityIndicators><title>Positive family history of essential tremor influences the motor phenotype of Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>4</total><last>2288</last><first>2285</first></pages><issn><json:string>0885-3185</json:string></issn><issue>15</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22772</json:string></doi><id>EF6CCAF1C41641351C7EB3AB11098051998933C0</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EF6CCAF1C41641351C7EB3AB11098051998933C0/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/EF6CCAF1C41641351C7EB3AB11098051998933C0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/EF6CCAF1C41641351C7EB3AB11098051998933C0/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Positive family history of essential tremor influences the motor phenotype of Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Positive family history of essential tremor influences the motor phenotype of Parkinson's disease</title><author><persName><forename type="first">Peter</forename><surname>Hedera</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, Tennesee 37232‐8552, USA</p></note><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><affiliation>Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author><author><persName><forename type="first">John Y.</forename><surname>Fang</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author><author><persName><forename type="first">Fenna</forename><surname>Phibbs</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author><author><persName><forename type="first">Michael K.</forename><surname>Cooper</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author><author><persName><forename type="first">P. David</forename><surname>Charles</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author><author><persName><forename type="first">Thomas L.</forename><surname>Davis</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>essential tremor</term></item><item><term>genetics</term></item><item><term>autosomal dominant inheritance</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-12-08">Received</change><change when="2009-08-17">Registration</change><change when="2009-11-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EF6CCAF1C41641351C7EB3AB11098051998933C0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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David</givenNames><familyName>Charles</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Thomas L.</givenNames><familyName>Davis</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">essential tremor</keyword><keyword xml:id="kwd3">genetics</keyword><keyword xml:id="kwd4">autosomal dominant inheritance</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (<i>r</i> = 0.83, <i>P</i> < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Positive family history of essential tremor influences the motor phenotype of Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Family History Influence on Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Positive family history of essential tremor influences the motor phenotype of Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Hedera</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><affiliation>Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA</affiliation><description>Correspondence: Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, Tennesee 37232‐8552, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John Y.</namePart><namePart type="family">Fang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fenna</namePart><namePart type="family">Phibbs</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael K.</namePart><namePart type="family">Cooper</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. David</namePart><namePart type="family">Charles</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas L.</namePart><namePart type="family">Davis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-11-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-08</dateCaptured><dateValid encoding="w3cdtf">2009-08-17</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">26</extent><extent unit="words">3832</extent></physicalDescription><abstract lang="fr">Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>essential tremor</topic><topic>genetics</topic><topic>autosomal dominant inheritance</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2285</start><end>2288</end><total>4</total></extent></part></relatedItem><identifier type="istex">EF6CCAF1C41641351C7EB3AB11098051998933C0</identifier><identifier type="DOI">10.1002/mds.22772</identifier><identifier type="ArticleID">MDS22772</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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