The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy
Identifieur interne : 000496 ( Istex/Corpus ); précédent : 000495; suivant : 000497The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy
Auteurs : François Tison ; Pierre Arne ; Chrystophe Sourgen ; Virginie Chrysostome ; Farid YeklefSource :
- Movement Disorders [ 0885-3185 ] ; 2000-11.
English descriptors
Abstract
OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.
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DOI: 10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1148">1148</biblScope><biblScope unit="page" to="1157">1157</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EAD057B06884149A2897C290EE4A708A943B2CEC</idno><idno type="DOI">10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6</idno><idno type="ArticleID">MDS1014</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anal sphincter electromyography</term><term>Multiple system atrophy</term><term>Parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>François Tison MD, PhD</name><affiliations><json:string>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Pierre Arne MD</name><affiliations><json:string>Laboratoire d'Explorations Fonctionnelles du Système Nerveux, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Chrystophe Sourgen RT</name><affiliations><json:string>Département d'Informatique Médicale, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Virginie Chrysostome MD</name><affiliations><json:string>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Farid Yeklef MD</name><affiliations><json:string>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Anal sphincter electromyography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinsonism</value></json:item></subject><language><json:string>eng</json:string></language><abstract>OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11"></date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1148">1148</biblScope><biblScope unit="page" to="1157">1157</biblScope></imprint></monogr><idno type="istex">EAD057B06884149A2897C290EE4A708A943B2CEC</idno><idno type="DOI">10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6</idno><idno type="ArticleID">MDS1014</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Anal sphincter electromyography</term></item><item><term>Multiple system atrophy</term></item><item><term>Parkinsonism</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-10-27">Received</change><change when="2000-05-09">Registration</change><change when="2000-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EAD057B06884149A2897C290EE4A708A943B2CEC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed.</p></section><section xml:id="abs1-2"><title type="main">METHODS</title><p>ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery.</p></section><section xml:id="abs1-3"><title type="main">RESULTS</title><p>All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG.</p></section><section xml:id="abs1-4"><title type="main">CONCLUSION</title><p>ASEMG was highly sensitive and rather specific for the diagnosis of MSA.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Anal Sphincter EMG in MSA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy</title></titleInfo><name type="personal"><namePart type="given">François</namePart><namePart type="family">Tison</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</affiliation><description>Correspondence: Service de Neurologie, Hôpital Haut‐Lévèque, Groupe Hospitalier Sud, CHU de Bordeaux, Avenue de Magellan, Pessac, 33604 France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Arne</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratoire d'Explorations Fonctionnelles du Système Nerveux, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chrystophe</namePart><namePart type="family">Sourgen</namePart><namePart type="termsOfAddress">RT</namePart><affiliation>Département d'Informatique Médicale, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Virginie</namePart><namePart type="family">Chrysostome</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Farid</namePart><namePart type="family">Yeklef</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, INSERM U‐330, Centre Hospitalier Universitaire, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2000-11</dateIssued><dateCaptured encoding="w3cdtf">1999-10-27</dateCaptured><dateValid encoding="w3cdtf">2000-05-09</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">26</extent><extent unit="words">5129</extent></physicalDescription><abstract lang="en">OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.</abstract><note type="funding">PHRC 1997</note><subject lang="en"><genre>Keywords</genre><topic>Anal sphincter electromyography</topic><topic>Multiple system atrophy</topic><topic>Parkinsonism</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1148</start><end>1157</end><total>10</total></extent></part></relatedItem><identifier type="istex">EAD057B06884149A2897C290EE4A708A943B2CEC</identifier><identifier type="DOI">10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6</identifier><identifier type="ArticleID">MDS1014</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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