Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease
Identifieur interne : 000271 ( Istex/Corpus ); précédent : 000270; suivant : 000272Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease
Auteurs : Antonio Currà ; Berardelli ; Rocco Agostino ; Nicola Modugno ; Cristiana Conti Puorger ; Neri Accornero ; Mario ManfrediSource :
- Movement Disorders [ 0885-3185 ] ; 1997-09.
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Abstract
Patients with Parkinson's disease are slower than normal subjects in executing sequential arm movements, and their bradykinesia worsens as the execution of motor sequences progresses. In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. They also suggest that patients with Parkinson's disease have more difficulty in executing internally determined than externally triggered sequential movements.
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DOI: 10.1002/mds.870120505
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Pozzilli (IS), Italy</mods:affiliation></affiliation></author><author><name sortKey="Manfredi, Mario" sort="Manfredi, Mario" uniqKey="Manfredi M" first="Mario" last="Manfredi">Mario Manfredi</name><affiliation><mods:affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. They also suggest that patients with Parkinson's disease have more difficulty in executing internally determined than externally triggered sequential movements.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Antonio Currà</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Dr. Berardelli</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Rocco Agostino</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Nicola Modugno</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Cristiana Conti Puorger</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Neri Accornero</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Mario Manfredi</name><affiliations><json:string>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</json:string><json:string>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Arm movement</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Motor pathways</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Movement time</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sequential movement</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Symmetry ratio</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Patients with Parkinson's disease are slower than normal subjects in executing sequential arm movements, and their bradykinesia worsens as the execution of motor sequences progresses. In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. 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In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. They also suggest that patients with Parkinson's disease have more difficulty in executing internally determined than externally triggered sequential movements.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Arm movement</term></item><item><term>Motor pathways</term></item><item><term>Movement time</term></item><item><term>Parkinson's disease</term></item><item><term>Sequential movement</term></item><item><term>Symmetry ratio</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-01-19">Received</change><change when="1996-11-18">Registration</change><change when="1997-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/0F3ED82307A4C3C7F96C1AC91EDB0DB134375616/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v12:5</doi><numberingGroup><numbering type="journalVolume" number="12">12</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="1997-09">September 1997</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.870120505</doi><idGroup><id type="unit" value="MDS870120505"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 1997 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="1996-01-19"></event><event type="manuscriptRevised" date="1996-10-14"></event><event type="manuscriptAccepted" date="1996-11-18"></event><event type="firstOnline" date="2004-11-04"></event><event type="publishedOnlineFinalForm" date="2004-11-04"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">646</numbering><numbering type="pageLast">654</numbering></numberingGroup><correspondenceTo>Dipartimento di Scienze Neurologiche, Università degli Studi di Roma “La Sapienza,” Viale dell'Università 30, 00185 Rome, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS870120505.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="42"></count></countGroup><titleGroup><title type="main" xml:lang="en">Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease</title><title type="short" xml:lang="en">SEQUENTIAL ARM MOVEMENTS IN PARKINSON'S DISEASE</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Antonio</givenNames><familyName>Currà</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Alfredo</givenNames><familyName>Berardelli</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Rocco</givenNames><familyName>Agostino</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Nicola</givenNames><familyName>Modugno</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Cristiana Conti</givenNames><familyName>Puorger</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Neri</givenNames><familyName>Accornero</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Mario</givenNames><familyName>Manfredi</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Arm movement</keyword><keyword xml:id="kwd2">Motor pathways</keyword><keyword xml:id="kwd3">Movement time</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">Sequential movement</keyword><keyword xml:id="kwd6">Symmetry ratio</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Patients with Parkinson's disease are slower than normal subjects in executing sequential arm movements, and their bradykinesia worsens as the execution of motor sequences progresses. In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. They also suggest that patients with Parkinson's disease have more difficulty in executing internally determined than externally triggered sequential movements.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SEQUENTIAL ARM MOVEMENTS IN PARKINSON'S DISEASE</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Currà</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Berardelli</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><description>Correspondence: Dipartimento di Scienze Neurologiche, Università degli Studi di Roma “La Sapienza,” Viale dell'Università 30, 00185 Rome, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rocco</namePart><namePart type="family">Agostino</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicola</namePart><namePart type="family">Modugno</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cristiana Conti</namePart><namePart type="family">Puorger</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neri</namePart><namePart type="family">Accornero</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mario</namePart><namePart type="family">Manfredi</namePart><affiliation>Department of Neurological Sciences, “La Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Mediterranean Neurologic Institute, NEUROMED, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1997-09</dateIssued><dateCaptured encoding="w3cdtf">1996-01-19</dateCaptured><dateValid encoding="w3cdtf">1996-11-18</dateValid><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">42</extent></physicalDescription><abstract lang="en">Patients with Parkinson's disease are slower than normal subjects in executing sequential arm movements, and their bradykinesia worsens as the execution of motor sequences progresses. In parkinsonian and normal subjects, we studied the execution of two types of fast sequential arm movements. The subjects had to perform a motor sequence following with their arm a path marked by six targets on a screen In one experimental condition, they performed the motor sequence without advance knowledge of its path and executed each submovement in response to the consecutive appearance of the targets on the screen (unknown motor sequences). In the other condition, all the targets appeared simultaneously on the screen before the subject moved, and the subject internally determined when to execute each submovement (known motor sequences). Patients were slower than normal subjects in executing both sequences. Patients and normal subjects were faster in executing known than unknown sequences, but the patients' percentage of total movement time diminished less. During the unknown condition, both groups tended to lengthen submovement duration whereas, during the known condition, both groups tended to correct this trend. Patients performed submovements during both sequences with longer acceleration phases. The submovement symmetry ratio of the velocity profile changed according to the direction of movement (up or down). We conclude that these findings depend mainly on the mode of movement execution. They also suggest that patients with Parkinson's disease have more difficulty in executing internally determined than externally triggered sequential movements.</abstract><subject lang="en"><genre>Keywords</genre><topic>Arm movement</topic><topic>Motor pathways</topic><topic>Movement time</topic><topic>Parkinson's disease</topic><topic>Sequential movement</topic><topic>Symmetry ratio</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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