Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
Identifieur interne : 000018 ( Istex/Corpus ); précédent : 000017; suivant : 000019Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
Auteurs : Martin Sommer ; Diane Ruge ; Frithjof Tergau ; Wolfgang Beuche ; Eckart Altenmüller ; Walter PaulusSource :
- Movement Disorders [ 0885-3185 ] ; 2002-09.
English descriptors
Abstract
We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age‐matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure‐eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure‐eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10205
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ISTEX:D40C82A6367E57BFC3954D733D15FF0471B17F06Le document en format XML
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In 15 patients with hand dystonia, 16 patients with blepharospasm, and age‐matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure‐eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure‐eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas. © 2002 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Martin Sommer MD</name><affiliations><json:string>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</json:string></affiliations></json:item><json:item><name>Diane Ruge MD</name><affiliations><json:string>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</json:string><json:string>Current Address: Department of Neurology, University of Frankfurt/Main, Frankfurt/Main, Germany</json:string></affiliations></json:item><json:item><name>Frithjof Tergau MD</name><affiliations><json:string>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang Beuche MD</name><affiliations><json:string>Department of Neurology, University of Göttingen, Göttingen, Germany</json:string><json:string>Current Address: Department of Neurology, St. Georg Hospital, Leipzig, Germany</json:string></affiliations></json:item><json:item><name>Eckart Altenmüller MD</name><affiliations><json:string>Institute of Music Physiology and Performing Arts Medicine, Hannover University of Music and Drama, Hannover, Germany</json:string></affiliations></json:item><json:item><name>Walter Paulus MD</name><affiliations><json:string>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transcranial magnetic stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>intracortical excitability</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. 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After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. 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In 15 patients with hand dystonia, 16 patients with blepharospasm, and age‐matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure‐eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure‐eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. 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In 15 patients with hand dystonia, 16 patients with blepharospasm, and age‐matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure‐eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure‐eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas. © 2002 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Intracortical Excitability in Dystonia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm</title></titleInfo><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Sommer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Diane</namePart><namePart type="family">Ruge</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</affiliation><affiliation>Current Address: Department of Neurology, University of Frankfurt/Main, Frankfurt/Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frithjof</namePart><namePart type="family">Tergau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Beuche</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Göttingen, Göttingen, Germany</affiliation><affiliation>Current Address: Department of Neurology, St. Georg Hospital, Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eckart</namePart><namePart type="family">Altenmüller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Music Physiology and Performing Arts Medicine, Hannover University of Music and Drama, Hannover, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Walter</namePart><namePart type="family">Paulus</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany</affiliation><description>Correspondence: Department of Clinical Neurophysiology, Postbox 37 42, D‐37070 Göttingen, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2002-09</dateIssued><dateCaptured encoding="w3cdtf">2001-04-26</dateCaptured><dateValid encoding="w3cdtf">2002-02-06</dateValid><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">2</extent><extent unit="references">29</extent><extent unit="words">4967</extent></physicalDescription><abstract lang="en">We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age‐matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure‐eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure‐eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4‐cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas. © 2002 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Dystonia</topic><topic>transcranial magnetic stimulation</topic><topic>intracortical excitability</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>1017</start><end>1025</end><total>9</total></extent></part></relatedItem><identifier type="istex">D40C82A6367E57BFC3954D733D15FF0471B17F06</identifier><identifier type="DOI">10.1002/mds.10205</identifier><identifier type="ArticleID">MDS10205</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2002 Movement Disorders Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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