Obesity, diabetes, and risk of Parkinson's disease
Identifieur interne : 000017 ( Istex/Corpus ); précédent : 000016; suivant : 000018Obesity, diabetes, and risk of Parkinson's disease
Auteurs : Natalia Palacios ; Xiang Gao ; Marjorie L. Mccullough ; Eric J. Jacobs ; Alpa V. Patel ; Tinisha Mayo ; Michael A. Schwarzschild ; Alberto AscherioSource :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
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- KwdEn :
Abstract
The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23855
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ISTEX:671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0ALe document en format XML
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We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Natalia Palacios ScD</name><affiliations><json:string>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Xiang Gao MD, PhD</name><affiliations><json:string>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</json:string><json:string>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Marjorie L. McCullough ScD</name><affiliations><json:string>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Eric J. Jacobs PhD</name><affiliations><json:string>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Alpa V. Patel PhD</name><affiliations><json:string>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Tinisha Mayo MPH</name><affiliations><json:string>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Michael A. Schwarzschild MD, PhD</name><affiliations><json:string>Massachusetts General Hospital, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Alberto Ascherio MD, DPH</name><affiliations><json:string>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</json:string><json:string>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</json:string><json:string>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>obesity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diabetes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>body mass index</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index >23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (>34.5 inches in men and >28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>8.277</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1727</abstractCharCount><pdfWordCount>4777</pdfWordCount><pdfCharCount>28944</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>263</abstractWordCount></qualityIndicators><title>Obesity, diabetes, and risk of Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>26</volume><pages><total>7</total><last>2259</last><first>2253</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23855</json:string></doi><id>671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: This work was funded by the National Institutes of Health (R01 NS048517; to A.A.) and the Training Program in Environmental Epidemiology, NIH Kirshstein National Research Service Award (T32 ES07069; to N.P.).</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease</title><author><persName><forename type="first">Natalia</forename><surname>Palacios</surname><roleName type="degree">ScD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA</p></note><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Xiang</forename><surname>Gao</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Marjorie L.</forename><surname>McCullough</surname><roleName type="degree">ScD</roleName></persName><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Eric J.</forename><surname>Jacobs</surname><roleName type="degree">PhD</roleName></persName><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Alpa V.</forename><surname>Patel</surname><roleName type="degree">PhD</roleName></persName><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Tinisha</forename><surname>Mayo</surname><roleName type="degree">MPH</roleName></persName><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Michael A.</forename><surname>Schwarzschild</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Massachusetts General Hospital, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Alberto</forename><surname>Ascherio</surname><roleName type="degree">MD, DPH</roleName></persName><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>obesity</term></item><item><term>diabetes</term></item><item><term>Parkinson's disease</term></item><item><term>body mass index</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-08-16">Received</change><change when="2011-05-26">Registration</change><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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href="file:MDS.MDS23855.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="7793"></count></countGroup><titleGroup><title type="main" xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease<link href="#fn18"></link><link href="#fn19"></link><link href="#fn20"></link></title><title type="short" xml:lang="en">Obesity, Diabetes, and Risk of Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Natalia</givenNames><familyName>Palacios</familyName><degrees>ScD</degrees></personName><contactDetails><email>palacios@hsph.harvard.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Xiang</givenNames><familyName>Gao</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Marjorie L.</givenNames><familyName>McCullough</familyName><degrees>ScD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eric J.</givenNames><familyName>Jacobs</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Alpa V.</givenNames><familyName>Patel</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Tinisha</givenNames><familyName>Mayo</familyName><degrees>MPH</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Michael A.</givenNames><familyName>Schwarzschild</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af4 #af5"><personName><givenNames>Alberto</givenNames><familyName>Ascherio</familyName><degrees>MD, DPH</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Massachusetts General Hospital, Boston, Massachusetts, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">obesity</keyword><keyword xml:id="kwd2">diabetes</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">body mass index</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; <i>P</i> trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; <i>P</i> trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; <i>P</i> heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn18"><p><b>Funding agencies:</b> This work was funded by the National Institutes of Health (R01 NS048517; to A.A.) and the Training Program in Environmental Epidemiology, NIH Kirshstein National Research Service Award (T32 ES07069; to N.P.).</p></note><note xml:id="fn19"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn20"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Obesity, diabetes, and risk of Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Obesity, Diabetes, and Risk of Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Obesity, diabetes, and risk of Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Natalia</namePart><namePart type="family">Palacios</namePart><namePart type="termsOfAddress">ScD</namePart><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><description>Correspondence: Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xiang</namePart><namePart type="family">Gao</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marjorie L.</namePart><namePart type="family">McCullough</namePart><namePart type="termsOfAddress">ScD</namePart><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric J.</namePart><namePart type="family">Jacobs</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alpa V.</namePart><namePart type="family">Patel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tinisha</namePart><namePart type="family">Mayo</namePart><namePart type="termsOfAddress">MPH</namePart><affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael A.</namePart><namePart type="family">Schwarzschild</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Massachusetts General Hospital, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Ascherio</namePart><namePart type="termsOfAddress">MD, DPH</namePart><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><dateCaptured encoding="w3cdtf">2010-08-16</dateCaptured><dateValid encoding="w3cdtf">2011-05-26</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">30</extent><extent unit="words">7793</extent></physicalDescription><abstract lang="en">The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This work was funded by the National Institutes of Health (R01 NS048517; to A.A.) and the Training Program in Environmental Epidemiology, NIH Kirshstein National Research Service Award (T32 ES07069; to N.P.).</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>obesity</topic><topic>diabetes</topic><topic>Parkinson's disease</topic><topic>body mass index</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2253</start><end>2259</end><total>7</total></extent></part></relatedItem><identifier type="istex">671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A</identifier><identifier type="DOI">10.1002/mds.23855</identifier><identifier type="ArticleID">MDS23855</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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