The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy
Identifieur interne : 003134 ( Istex/Checkpoint ); précédent : 003133; suivant : 003135The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy
Auteurs : François Tison [France] ; Pierre Arne [France] ; Chrystophe Sourgen [France] ; Virginie Chrysostome [France] ; Farid Yeklef [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-11.
English descriptors
Abstract
OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.
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DOI: 10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1148">1148</biblScope><biblScope unit="page" to="1157">1157</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EAD057B06884149A2897C290EE4A708A943B2CEC</idno><idno type="DOI">10.1002/1531-8257(200011)15:6<1148::AID-MDS1014>3.0.CO;2-6</idno><idno type="ArticleID">MDS1014</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anal sphincter electromyography</term><term>Multiple system atrophy</term><term>Parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: To assess the value of external anal sphincter electromyography (ASEMG) for the diagnosis of multiple system atrophy (MSA) among various causes of parkinsonism. ASEMG denervation profiles have previously been proposed as a diagnosis test for MSA, but their specificity is disputed. METHODS: ASEMG variables of 52 parkinsonian patients were analyzed according to the clinical diagnosis: MSA (n = 31) or no MSA (n = 21). Mean motor unit potential duration, percentage of polyphasicity, and the electromyographer's interpretation were analyzed according to clinical diagnosis, disease duration, genitourinary symptoms, gender, parity, and history of pelvic surgery. RESULTS: All patients with MSA showed ASEMG denervation. Mean motor unit potential duration was the most discriminant variable. No patient with MSA had a mean duration less than 12 ms and no patient without MSA had one greater than 16 ms. ASEMG discriminates between patients with MSA and Parkinson's disease. Using a threshold of 13 ms, the sensitivity was 80% and specificity was almost 70% (positive predictive value, 80%) for the diagnosis of MSA. Age, history of pelvic surgery, and to a lesser extent, female gender, parity, disease duration, and presence of urinary symptoms increased the likelihood of abnormal ASEMG. CONCLUSION: ASEMG was highly sensitive and rather specific for the diagnosis of MSA.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Bordeaux</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></noRegion><name sortKey="Arne, Pierre" sort="Arne, Pierre" uniqKey="Arne P" first="Pierre" last="Arne">Pierre Arne</name><name sortKey="Chrysostome, Virginie" sort="Chrysostome, Virginie" uniqKey="Chrysostome V" first="Virginie" last="Chrysostome">Virginie Chrysostome</name><name sortKey="Sourgen, Chrystophe" sort="Sourgen, Chrystophe" uniqKey="Sourgen C" first="Chrystophe" last="Sourgen">Chrystophe Sourgen</name><name sortKey="Yeklef, Farid" sort="Yeklef, Farid" uniqKey="Yeklef F" first="Farid" last="Yeklef">Farid Yeklef</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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