Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity
Identifieur interne : 002A89 ( Istex/Checkpoint ); précédent : 002A88; suivant : 002A90Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity
Auteurs : Cathy Chuang [États-Unis] ; Anne Constantino [États-Unis] ; Casilda Balmaceda [États-Unis] ; David Eidelberg [États-Unis] ; Steven J. Frucht [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-03.
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- KwdEn :
Abstract
Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10344
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<front><div type="abstract" xml:lang="en">Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society</div>
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