Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
Identifieur interne : 001B02 ( Istex/Checkpoint ); précédent : 001B01; suivant : 001B03Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
Auteurs : Naomi M. Warren [Royaume-Uni] ; Margaret A. Piggott [Royaume-Uni] ; Elizabeth Greally [Royaume-Uni] ; Michelle Lake [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; David J. Burn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
English descriptors
Abstract
Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, 125I PE2I and dopamine D2 receptors, 125I epidepride) and cholinergic (nicotinic α4β2 receptors, 125I 5IA85380 and muscarinic M1 receptors, 3H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n = 15) and controls (n = 32). In PSP, there was a marked loss of dopamine transporter and nicotinic α4β2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurones. Striatal D2 receptors were increased in the caudate and muscarinic M1 receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21573
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:1BC8FD9B9FF157AB7022B2DC10AE2D59F99113ECLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy</title>
<author><name sortKey="Warren, Naomi M" sort="Warren, Naomi M" uniqKey="Warren N" first="Naomi M." last="Warren">Naomi M. Warren</name>
</author>
<author><name sortKey="Piggott, Margaret A" sort="Piggott, Margaret A" uniqKey="Piggott M" first="Margaret A." last="Piggott">Margaret A. Piggott</name>
</author>
<author><name sortKey="Greally, Elizabeth" sort="Greally, Elizabeth" uniqKey="Greally E" first="Elizabeth" last="Greally">Elizabeth Greally</name>
</author>
<author><name sortKey="Lake, Michelle" sort="Lake, Michelle" uniqKey="Lake M" first="Michelle" last="Lake">Michelle Lake</name>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation><country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1BC8FD9B9FF157AB7022B2DC10AE2D59F99113EC</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21573</idno>
<idno type="url">https://api.istex.fr/document/1BC8FD9B9FF157AB7022B2DC10AE2D59F99113EC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001189</idno>
<idno type="wicri:Area/Istex/Curation">001189</idno>
<idno type="wicri:Area/Istex/Checkpoint">001B02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy</title>
<author><name sortKey="Warren, Naomi M" sort="Warren, Naomi M" uniqKey="Warren N" first="Naomi M." last="Warren">Naomi M. Warren</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piggott, Margaret A" sort="Piggott, Margaret A" uniqKey="Piggott M" first="Margaret A." last="Piggott">Margaret A. Piggott</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Greally, Elizabeth" sort="Greally, Elizabeth" uniqKey="Greally E" first="Elizabeth" last="Greally">Elizabeth Greally</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lake, Michelle" sort="Lake, Michelle" uniqKey="Lake M" first="Michelle" last="Lake">Michelle Lake</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sara Koe PSP Research Centre, Institute of Neurology, University College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-08-15">2007-08-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1594">1594</biblScope>
<biblScope unit="page" to="1600">1600</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">1BC8FD9B9FF157AB7022B2DC10AE2D59F99113EC</idno>
<idno type="DOI">10.1002/mds.21573</idno>
<idno type="ArticleID">MDS21573</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal ganglia</term>
<term>cholinergic</term>
<term>dopaminergic</term>
<term>progressive supranuclear palsy</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, 125I PE2I and dopamine D2 receptors, 125I epidepride) and cholinergic (nicotinic α4β2 receptors, 125I 5IA85380 and muscarinic M1 receptors, 3H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n = 15) and controls (n = 32). In PSP, there was a marked loss of dopamine transporter and nicotinic α4β2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurones. Striatal D2 receptors were increased in the caudate and muscarinic M1 receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Warren, Naomi M" sort="Warren, Naomi M" uniqKey="Warren N" first="Naomi M." last="Warren">Naomi M. Warren</name>
</noRegion>
<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<name sortKey="Greally, Elizabeth" sort="Greally, Elizabeth" uniqKey="Greally E" first="Elizabeth" last="Greally">Elizabeth Greally</name>
<name sortKey="Lake, Michelle" sort="Lake, Michelle" uniqKey="Lake M" first="Michelle" last="Lake">Michelle Lake</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Piggott, Margaret A" sort="Piggott, Margaret A" uniqKey="Piggott M" first="Margaret A." last="Piggott">Margaret A. Piggott</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B02 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001B02 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:1BC8FD9B9FF157AB7022B2DC10AE2D59F99113EC |texte= Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy }}
This area was generated with Dilib version V0.6.23. |