Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Identifieur interne : 000C36 ( Istex/Checkpoint ); précédent : 000C35; suivant : 000C37Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Auteurs : Christopher G. Goetz [États-Unis] ; Glenn T. Stebbins [États-Unis] ; David Wolff [États-Unis] ; William Deleeuw [États-Unis] ; Helen Bronte-Stewart [États-Unis] ; Rodger Elble [États-Unis] ; Mark Hallett [États-Unis] ; John Nutt [États-Unis] ; Lorraine Ramig [États-Unis] ; Terence Sanger [États-Unis] ; Allan D. Wu [États-Unis] ; Peter H. Kraus [Allemagne] ; Lucia M. Blasucci [États-Unis] ; Ejaz A. Shamim [États-Unis] ; Kapil D. Sethi [États-Unis] ; Jennifer Spielman [États-Unis] ; Ken Kubota [États-Unis] ; Andrew S. Grove [États-Unis] ; Eric Dishman [États-Unis] ; C. Barr Taylor [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
English descriptors
Abstract
We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22379
Affiliations:
- Allemagne, États-Unis
- Californie, Colorado, District de Columbia, Géorgie (États-Unis), Illinois, Maryland, Oregon
- Washington (district de Columbia)
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ISTEX:909FDE21B6C19AF13F9C08E1C3796068E9748DB3Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>accelerometer</term>
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<front><div type="abstract" xml:lang="en">We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</div>
</front>
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<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name>
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<name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name>
<name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name>
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<name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name>
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<name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name>
<name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name>
<name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name>
<name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C. Barr" last="Taylor">C. Barr Taylor</name>
<name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name>
<name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name>
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