Nonlinear decline of mini‐mental state examination in Parkinson's disease
Identifieur interne : 000248 ( Istex/Checkpoint ); précédent : 000247; suivant : 000249Nonlinear decline of mini‐mental state examination in Parkinson's disease
Auteurs : Dag Aarsland [Norvège] ; Graciela Muniz [Royaume-Uni] ; Fiona Matthews [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
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Abstract
The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini‐mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23416
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="334">334</biblScope><biblScope unit="page" to="337">337</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6EF7AF25342A962F332A2C83966E3BF0561FB594</idno><idno type="DOI">10.1002/mds.23416</idno><idno type="ArticleID">MDS23416</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognitive impairment</term><term>course</term><term>nonlinear</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini‐mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Norvège</li><li>Royaume-Uni</li></country></list><tree><country name="Norvège"><noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Muniz, Graciela" sort="Muniz, Graciela" uniqKey="Muniz G" first="Graciela" last="Muniz">Graciela Muniz</name></noRegion><name sortKey="Matthews, Fiona" sort="Matthews, Fiona" uniqKey="Matthews F" first="Fiona" last="Matthews">Fiona Matthews</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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