Nonlinear decline of mini‐mental state examination in Parkinson's disease
Identifieur interne : 000F22 ( Istex/Corpus ); précédent : 000F21; suivant : 000F23Nonlinear decline of mini‐mental state examination in Parkinson's disease
Auteurs : Dag Aarsland ; Graciela Muniz ; Fiona MatthewsSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
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Abstract
The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini‐mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23416
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ISTEX:6EF7AF25342A962F332A2C83966E3BF0561FB594Le document en format XML
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Full financial disclosures and author roles can be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>cognitive impairment</topic><topic>course</topic><topic>nonlinear</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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