Weight gain following subthalamic nucleus deep brain stimulation: a PET study.
Identifieur interne : 000002 ( Hal/Checkpoint ); précédent : 000001; suivant : 000003Weight gain following subthalamic nucleus deep brain stimulation: a PET study.
Auteurs : Paul Sauleau [France] ; Florence Le Jeune [France] ; Sophie Drapier ; Jean-François Houvenaghel ; Thibaut Dondaine [France] ; Claire Haegelen [France] ; Florent Lalys [France] ; Gabriel Robert ; Dominique Drapier [France] ; Marc Vérin [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2014-11-30.
Abstract
Several hypotheses have been put forward to explain weight gain after deep brain stimulation (DBS), but none provides a fully satisfactory account of this adverse effect. We analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease. Motor complications (United Parkinson's Disease Rating Scale [UPDRS]-IV scores) and dopaminergic medication were included in the analysis to control for their possible influence on brain metabolism. Mean ± standard deviation (SD) body mass index increased significantly by 0.8 ± 1.5 kg/m(2) (P = 0.03). Correlations were found between weight gain and changes in brain metabolism in limbic and associative areas, including the orbitofrontal cortex (Brodmann areas [BAs] 10 and 11), lateral and medial parts of the temporal lobe (BAs 20, 21, 22,39 and 42), anterior cingulate cortex (BA 32), and retrosplenial cortex (BA 30). However, we found no correlation between weight gain and metabolic changes in sensorimotor areas. These findings suggest that changes in associative and limbic processes contribute to weight gain after subthalamic nucleus DBS in Parkinson's disease.
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DOI: 10.1002/mds.26063
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35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.ueb.eu/</ref></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>Centre hospitalier universitaire [Rennes]</orgName><orgName type="acronym">CHU</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle><tutelle active="#struct-357205" type="direct"><org type="institution" xml:id="struct-357205" status="INCOMING"><orgName>Institut des Neurosciences Cliniques de Rennes (INCR)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.1002/mds.26063</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2014-11-30</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several hypotheses have been put forward to explain weight gain after deep brain stimulation (DBS), but none provides a fully satisfactory account of this adverse effect. We analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease. Motor complications (United Parkinson's Disease Rating Scale [UPDRS]-IV scores) and dopaminergic medication were included in the analysis to control for their possible influence on brain metabolism. Mean ± standard deviation (SD) body mass index increased significantly by 0.8 ± 1.5 kg/m(2) (P = 0.03). Correlations were found between weight gain and changes in brain metabolism in limbic and associative areas, including the orbitofrontal cortex (Brodmann areas [BAs] 10 and 11), lateral and medial parts of the temporal lobe (BAs 20, 21, 22,39 and 42), anterior cingulate cortex (BA 32), and retrosplenial cortex (BA 30). However, we found no correlation between weight gain and metabolic changes in sensorimotor areas. These findings suggest that changes in associative and limbic processes contribute to weight gain after subthalamic nucleus DBS in Parkinson's disease.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Weight gain following subthalamic nucleus deep brain stimulation: a PET study.</title><author role="aut"><persName><forename type="first">Paul</forename><surname>Sauleau</surname></persName><email></email><idno type="halauthor">296413</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Florence</forename><surname>Le Jeune</surname></persName><email></email><idno type="idhal">florence-le-jeune</idno><idno type="halauthor">646117</idno><affiliation ref="#struct-169895"></affiliation></author><author role="aut"><persName><forename type="first">Sophie</forename><surname>Drapier</surname></persName><email></email><idno type="halauthor">773331</idno></author><author role="aut"><persName><forename type="first">Jean-François</forename><surname>Houvenaghel</surname></persName><email></email><idno type="halauthor">1147005</idno></author><author role="aut"><persName><forename type="first">Thibaut</forename><surname>Dondaine</surname></persName><email></email><idno type="halauthor">740415</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Haegelen</surname></persName><email></email><idno type="halauthor">169922</idno><affiliation ref="#struct-33417"></affiliation><affiliation ref="#struct-182223"></affiliation></author><author role="aut"><persName><forename type="first">Florent</forename><surname>Lalys</surname></persName><email></email><idno type="halauthor">691977</idno><affiliation ref="#struct-182223"></affiliation></author><author role="aut"><persName><forename type="first">Gabriel</forename><surname>Robert</surname></persName><email></email><idno type="halauthor">76122</idno></author><author role="aut"><persName><forename type="first">Dominique</forename><surname>Drapier</surname></persName><email></email><idno type="halauthor">547173</idno><affiliation ref="#struct-238036"></affiliation><affiliation ref="#struct-238034"></affiliation></author><author role="aut"><persName><forename type="first">Marc</forename><surname>Vérin</surname></persName><email></email><idno type="halauthor">362876</idno><affiliation ref="#struct-238036"></affiliation><affiliation ref="#struct-155115"></affiliation></author><editor role="depositor"><persName><forename>Laurent</forename><surname>Jonchère</surname></persName><email>laurent.jonchere@univ-rennes1.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2015-03-20 14:22:50</date><date type="whenModified">2015-10-05 16:51:47</date><date type="whenReleased">2015-03-20 14:22:50</date><date type="whenProduced">2014-11-30</date></edition><respStmt><resp>contributor</resp><name key="113861"><persName><forename>Laurent</forename><surname>Jonchère</surname></persName><email>laurent.jonchere@univ-rennes1.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-01133822</idno><idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133822</idno><idno type="halBibtex">sauleau:hal-01133822</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2014, 29 (14), pp.1781-7. <10.1002/mds.26063></idno><idno type="halRef">Movement Disorders, Wiley, 2014, 29 (14), pp.1781-7. <10.1002/mds.26063></idno></publicationStmt><seriesStmt><idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno><idno type="stamp" n="CNGC">Comportement et noyaux gris centraux EA4712</idno><idno type="stamp" n="FNCLCC" p="INSERM">UNICANCER</idno><idno type="stamp" n="MARQUIS" p="FNCLCC">Centre Eugène Marquis</idno><idno type="stamp" n="HL">Publications CHU - Rennes 1</idno><idno type="stamp" n="LTSI" p="INSERM">Laboratoire Traitement du Signal et de l'Image</idno><idno type="stamp" n="LTSI-MEDICIS" p="LTSI">Medicis - Equipe LTSI</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Weight gain following subthalamic nucleus deep brain stimulation: a PET study.</title><author role="aut"><persName><forename type="first">Paul</forename><surname>Sauleau</surname></persName><idno type="halAuthorId">296413</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Florence</forename><surname>Le Jeune</surname></persName><idno type="idHal">florence-le-jeune</idno><idno type="halAuthorId">646117</idno><affiliation ref="#struct-169895"></affiliation></author><author role="aut"><persName><forename type="first">Sophie</forename><surname>Drapier</surname></persName><idno type="halAuthorId">773331</idno></author><author role="aut"><persName><forename type="first">Jean-François</forename><surname>Houvenaghel</surname></persName><idno type="halAuthorId">1147005</idno></author><author role="aut"><persName><forename type="first">Thibaut</forename><surname>Dondaine</surname></persName><idno type="halAuthorId">740415</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Haegelen</surname></persName><idno type="halAuthorId">169922</idno><affiliation ref="#struct-33417"></affiliation><affiliation ref="#struct-182223"></affiliation></author><author role="aut"><persName><forename type="first">Florent</forename><surname>Lalys</surname></persName><idno type="halAuthorId">691977</idno><affiliation ref="#struct-182223"></affiliation></author><author role="aut"><persName><forename type="first">Gabriel</forename><surname>Robert</surname></persName><idno type="halAuthorId">76122</idno></author><author role="aut"><persName><forename type="first">Dominique</forename><surname>Drapier</surname></persName><idno type="halAuthorId">547173</idno><affiliation ref="#struct-238036"></affiliation><affiliation ref="#struct-238034"></affiliation></author><author role="aut"><persName><forename type="first">Marc</forename><surname>Vérin</surname></persName><idno type="halAuthorId">362876</idno><affiliation ref="#struct-238036"></affiliation><affiliation ref="#struct-155115"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">29</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="pp">1781-7</biblScope><date type="datePub">2014-11-30</date></imprint></monogr><idno type="pubmed">25382049</idno><idno type="doi">10.1002/mds.26063</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Several hypotheses have been put forward to explain weight gain after deep brain stimulation (DBS), but none provides a fully satisfactory account of this adverse effect. We analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease. Motor complications (United Parkinson's Disease Rating Scale [UPDRS]-IV scores) and dopaminergic medication were included in the analysis to control for their possible influence on brain metabolism. Mean ± standard deviation (SD) body mass index increased significantly by 0.8 ± 1.5 kg/m(2) (P = 0.03). Correlations were found between weight gain and changes in brain metabolism in limbic and associative areas, including the orbitofrontal cortex (Brodmann areas [BAs] 10 and 11), lateral and medial parts of the temporal lobe (BAs 20, 21, 22,39 and 42), anterior cingulate cortex (BA 32), and retrosplenial cortex (BA 30). However, we found no correlation between weight gain and metabolic changes in sensorimotor areas. These findings suggest that changes in associative and limbic processes contribute to weight gain after subthalamic nucleus DBS in Parkinson's disease.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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