Sleep aspects on video-polysomnography in LRRK2 mutation carriers
Identifieur interne : 000001 ( Hal/Checkpoint ); précédent : 000000; suivant : 000002Sleep aspects on video-polysomnography in LRRK2 mutation carriers
Auteurs : Mickael Ehrminger [France] ; Smaranda Leu-Semenescu [France] ; Florence Cormier [France] ; Jean-Christophe Corvol [France] ; Marie Vidailhet [France] ; Eden Debellemaniere [France] ; Alexis Brice [France] ; Isabelle Arnulf [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2015.
English descriptors
Abstract
Background : Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown.Methods : Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography.Results : No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine-rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine-rich repeat kinase 2–associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.Conclusions : The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.
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DOI: 10.1002/mds.26412
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<author><name sortKey="Debellemaniere, Eden" sort="Debellemaniere, Eden" uniqKey="Debellemaniere E" first="Eden" last="Debellemaniere">Eden Debellemaniere</name>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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</analytic>
<idno type="DOI">10.1002/mds.26412</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Parkinson's disease</term>
<term>REM sleep behavior disorder</term>
<term>genetic</term>
<term>periodic leg movements</term>
<term>sleepiness</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background : Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown.Methods : Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography.Results : No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine-rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine-rich repeat kinase 2–associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.Conclusions : The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Sleep aspects on video-polysomnography in LRRK2 mutation carriers</title>
<author role="aut"><persName><forename type="first">Mickael</forename>
<surname>Ehrminger</surname>
</persName>
<email></email>
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<affiliation ref="#struct-439727"></affiliation>
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<author role="aut"><persName><forename type="first">Smaranda</forename>
<surname>Leu-Semenescu</surname>
</persName>
<email></email>
<idno type="halauthor">467352</idno>
<affiliation ref="#struct-246044"></affiliation>
<affiliation ref="#struct-439727"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Florence</forename>
<surname>Cormier</surname>
</persName>
<email></email>
<idno type="halauthor">1235756</idno>
<affiliation ref="#struct-246044"></affiliation>
<affiliation ref="#struct-439727"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Christophe</forename>
<surname>Corvol</surname>
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<email></email>
<idno type="halauthor">108532</idno>
<affiliation ref="#struct-246044"></affiliation>
<affiliation ref="#struct-439727"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie</forename>
<surname>Vidailhet</surname>
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<email></email>
<idno type="halauthor">216232</idno>
<affiliation ref="#struct-246044"></affiliation>
<affiliation ref="#struct-439727"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Eden</forename>
<surname>Debellemaniere</surname>
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<email></email>
<idno type="halauthor">1235757</idno>
<affiliation ref="#struct-246044"></affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Sleep aspects on video-polysomnography in LRRK2 mutation carriers</title>
<author role="aut"><persName><forename type="first">Mickael</forename>
<surname>Ehrminger</surname>
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<author role="aut"><persName><forename type="first">Smaranda</forename>
<surname>Leu-Semenescu</surname>
</persName>
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<author role="aut"><persName><forename type="first">Florence</forename>
<surname>Cormier</surname>
</persName>
<idno type="halAuthorId">1235756</idno>
<affiliation ref="#struct-246044"></affiliation>
<affiliation ref="#struct-439727"></affiliation>
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<author role="aut"><persName><forename type="first">Jean-Christophe</forename>
<surname>Corvol</surname>
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<author role="aut"><persName><forename type="first">Marie</forename>
<surname>Vidailhet</surname>
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<author role="aut"><persName><forename type="first">Eden</forename>
<surname>Debellemaniere</surname>
</persName>
<idno type="halAuthorId">1235757</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexis</forename>
<surname>Brice</surname>
</persName>
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<author role="crp"><persName><forename type="first">Isabelle</forename>
<surname>Arnulf</surname>
</persName>
<email>isabelle.arnulf@psl.aphp.fr</email>
<idno type="halAuthorId">411600</idno>
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<monogr><idno type="halJournalId" status="VALID">17211</idno>
<idno type="issn">0885-3185</idno>
<idno type="eissn">1531-8257</idno>
<title level="j">Movement Disorders</title>
<imprint><publisher>Wiley</publisher>
<date type="datePub">2015</date>
<date type="dateEpub">2015-10-15</date>
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<idno type="doi">10.1002/mds.26412</idno>
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<profileDesc><langUsage><language ident="en">English</language>
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<textClass><keywords scheme="author"><term xml:lang="en">sleepiness</term>
<term xml:lang="en">periodic leg movements</term>
<term xml:lang="en">REM sleep behavior disorder</term>
<term xml:lang="en">genetic</term>
<term xml:lang="en">Parkinson's disease</term>
</keywords>
<classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
<classCode scheme="halDomain" n="sdv.gen">Life Sciences [q-bio]/Genetics</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Background : Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown.Methods : Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography.Results : No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine-rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine-rich repeat kinase 2–associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.Conclusions : The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.</abstract>
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