Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.
Identifieur interne : 002364 ( PubMed/Curation ); précédent : 002363; suivant : 002365Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.
Auteurs : S. Shichijo [Japon] ; N. Keicho ; H T Long ; T. Quy ; N C Phi ; L D Ha ; V V Ban ; S. Itoyama ; C-J Hu ; N. Komatsu ; T. Kirikae ; F. Kirikae ; S. Shirasawa ; M. Kaji ; T. Fukuda ; M. Sata ; T. Kuratsuji ; K. Itoh ; T. SasazukiSource :
- Tissue antigens [ 0001-2815 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Immunité, Peptides, Système immunitaire, Sérum, Virus du SRAS.
- sang : Immunoglobuline G.
- Humains, Rhéologie, Test ELISA.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Immunoglobulin G.
- immunology : Immune System, Immunity, Peptides, SARS Virus, Serum.
- Enzyme-Linked Immunosorbent Assay, Humans, Rheology.
Abstract
In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.
DOI: 10.1111/j.1399-0039.2004.00314.x
PubMed: 15496204
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Shichijo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Kurume University School of Medicine, Asahi-machi, Kurume, Fukuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology, Kurume University School of Medicine, Asahi-machi, Kurume, Fukuoka</wicri:regionArea></affiliation></author><author><name sortKey="Keicho, N" sort="Keicho, N" uniqKey="Keicho N" first="N" last="Keicho">N. Keicho</name></author><author><name sortKey="Long, H T" sort="Long, H T" uniqKey="Long H" first="H T" last="Long">H T Long</name></author><author><name sortKey="Quy, T" sort="Quy, T" uniqKey="Quy T" first="T" last="Quy">T. Quy</name></author><author><name sortKey="Phi, N C" sort="Phi, N C" uniqKey="Phi N" first="N C" last="Phi">N C Phi</name></author><author><name sortKey="Ha, L D" sort="Ha, L D" uniqKey="Ha L" first="L D" last="Ha">L D Ha</name></author><author><name sortKey="Ban, V V" sort="Ban, V V" uniqKey="Ban V" first="V V" last="Ban">V V Ban</name></author><author><name sortKey="Itoyama, S" sort="Itoyama, S" uniqKey="Itoyama S" first="S" last="Itoyama">S. Itoyama</name></author><author><name sortKey="Hu, C J" sort="Hu, C J" uniqKey="Hu C" first="C-J" last="Hu">C-J Hu</name></author><author><name sortKey="Komatsu, N" sort="Komatsu, N" uniqKey="Komatsu N" first="N" last="Komatsu">N. Komatsu</name></author><author><name sortKey="Kirikae, T" sort="Kirikae, T" uniqKey="Kirikae T" first="T" last="Kirikae">T. Kirikae</name></author><author><name sortKey="Kirikae, F" sort="Kirikae, F" uniqKey="Kirikae F" first="F" last="Kirikae">F. Kirikae</name></author><author><name sortKey="Shirasawa, S" sort="Shirasawa, S" uniqKey="Shirasawa S" first="S" last="Shirasawa">S. Shirasawa</name></author><author><name sortKey="Kaji, M" sort="Kaji, M" uniqKey="Kaji M" first="M" last="Kaji">M. Kaji</name></author><author><name sortKey="Fukuda, T" sort="Fukuda, T" uniqKey="Fukuda T" first="T" last="Fukuda">T. Fukuda</name></author><author><name sortKey="Sata, M" sort="Sata, M" uniqKey="Sata M" first="M" last="Sata">M. Sata</name></author><author><name sortKey="Kuratsuji, T" sort="Kuratsuji, T" uniqKey="Kuratsuji T" first="T" last="Kuratsuji">T. Kuratsuji</name></author><author><name sortKey="Itoh, K" sort="Itoh, K" uniqKey="Itoh K" first="K" last="Itoh">K. Itoh</name></author><author><name sortKey="Sasazuki, T" sort="Sasazuki, T" uniqKey="Sasazuki T" first="T" last="Sasazuki">T. Sasazuki</name></author></analytic><series><title level="j">Tissue antigens</title><idno type="ISSN">0001-2815</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immune System (immunology)</term><term>Immunity (immunology)</term><term>Immunoglobulin G (blood)</term><term>Peptides (immunology)</term><term>Rheology</term><term>SARS Virus (immunology)</term><term>Serum (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Immunité (immunologie)</term><term>Immunoglobuline G (sang)</term><term>Peptides (immunologie)</term><term>Rhéologie</term><term>Système immunitaire (immunologie)</term><term>Sérum (immunologie)</term><term>Test ELISA</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité</term><term>Peptides</term><term>Système immunitaire</term><term>Sérum</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immune System</term><term>Immunity</term><term>Peptides</term><term>SARS Virus</term><term>Serum</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Rheology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Rhéologie</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15496204</PMID><DateCompleted><Year>2005</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2004</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-2815</ISSN><JournalIssue CitedMedium="Print"><Volume>64</Volume><Issue>5</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Tissue antigens</Title><ISOAbbreviation>Tissue Antigens</ISOAbbreviation></Journal><ArticleTitle>Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.</ArticleTitle><Pagination><MedlinePgn>600-7</MedlinePgn></Pagination><Abstract><AbstractText>In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shichijo</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Immunology, Kurume University School of Medicine, Asahi-machi, Kurume, Fukuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keicho</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Long</LastName><ForeName>H T</ForeName><Initials>HT</Initials></Author><Author ValidYN="Y"><LastName>Quy</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Phi</LastName><ForeName>N C</ForeName><Initials>NC</Initials></Author><Author ValidYN="Y"><LastName>Ha</LastName><ForeName>L D</ForeName><Initials>LD</Initials></Author><Author ValidYN="Y"><LastName>Ban</LastName><ForeName>V V</ForeName><Initials>VV</Initials></Author><Author ValidYN="Y"><LastName>Itoyama</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>C-J</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Komatsu</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Kirikae</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kirikae</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Shirasawa</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kaji</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fukuda</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Sata</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kuratsuji</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Itoh</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Sasazuki</LastName><ForeName>T</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Tissue Antigens</MedlineTA><NlmUniqueID>0331072</NlmUniqueID><ISSNLinking>0001-2815</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007107" MajorTopicYN="N">Immune System</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007109" MajorTopicYN="N">Immunity</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012212" MajorTopicYN="N">Rheology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044967" MajorTopicYN="N">Serum</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>10</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>10</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15496204</ArticleId><ArticleId IdType="pii">TAN314</ArticleId><ArticleId IdType="doi">10.1111/j.1399-0039.2004.00314.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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