MersV1, PubMed, Curation, bibRecord, 001F69

microRNAs and lung cancer: tumors and 22-mers.

Identifieur interne : 001F69 ( PubMed/Curation ); précédent : 001F68; suivant : 001F70

microRNAs and lung cancer: tumors and 22-mers.

Auteurs : Liqin Du [États-Unis] ; Alexander Pertsemlidis

Source :

Cancer metastasis reviews [ 1573-7233 ] ; 2010.

RBID : pubmed:20130964

Descripteurs français

KwdFr :
- Animaux, Carcinome pulmonaire non à petites cellules (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (diagnostic), Carcinome pulmonaire non à petites cellules (génétique), Ciblage de gène (), Gènes suppresseurs de tumeur (physiologie), Humains, Métastase tumorale, Néovascularisation pathologique (génétique), Prolifération cellulaire, Pronostic, Régulation de l'expression des gènes tumoraux, Thérapie génétique (), Transformation cellulaire néoplasique (génétique), Tumeurs du poumon (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (diagnostic), Tumeurs du poumon (génétique), microARN (génétique), microARN (physiologie).
MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- diagnostic : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- génétique : Carcinome pulmonaire non à petites cellules, Néovascularisation pathologique, Transformation cellulaire néoplasique, Tumeurs du poumon, microARN.
- physiologie : Gènes suppresseurs de tumeur, microARN.
- Animaux, Carcinome pulmonaire non à petites cellules, Ciblage de gène, Humains, Métastase tumorale, Prolifération cellulaire, Pronostic, Régulation de l'expression des gènes tumoraux, Thérapie génétique, Tumeurs du poumon.

English descriptors

KwdEn :
- Animals, Carcinoma, Non-Small-Cell Lung (diagnosis), Carcinoma, Non-Small-Cell Lung (genetics), Carcinoma, Non-Small-Cell Lung (pathology), Carcinoma, Non-Small-Cell Lung (therapy), Cell Proliferation, Cell Transformation, Neoplastic (genetics), Gene Expression Regulation, Neoplastic, Gene Targeting (methods), Genes, Tumor Suppressor (physiology), Genetic Therapy (methods), Humans, Lung Neoplasms (diagnosis), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Lung Neoplasms (therapy), MicroRNAs (genetics), MicroRNAs (physiology), Neoplasm Metastasis, Neovascularization, Pathologic (genetics), Prognosis.
MESH :
- chemical , genetics : MicroRNAs.
- diagnosis : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- genetics : Carcinoma, Non-Small-Cell Lung, Cell Transformation, Neoplastic, Lung Neoplasms, Neovascularization, Pathologic.
- methods : Gene Targeting, Genetic Therapy.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- physiology : Genes, Tumor Suppressor, MicroRNAs.
- therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Animals, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Metastasis, Prognosis.

Abstract

Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.

DOI: 10.1007/s10555-010-9204-9
PubMed: 20130964

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