Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome.
Identifieur interne : 001979 ( PubMed/Curation ); précédent : 001978; suivant : 001980Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome.
Auteurs : Ziad A. Memish ; Jaffar A. Al-Tawfiq ; Hatem Q. Makhdoom ; Abdullah Assiri ; Raafat F. Alhakeem ; Ali Albarrak ; Sarah Alsubaie ; Abdullah A. Al-Rabeeah ; Waleed H. Hajomar ; Raheela Hussain ; Ali M. Kheyami ; Abdullah Almutairi ; Esam I. Azhar ; Christian Drosten [Allemagne] ; Simon J. Watson ; Paul Kellam ; Matthew Cotten ; Alimuddin Zumla [Royaume-Uni]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Appareil respiratoire, Infections à coronavirus.
- Charge virale, Humains, Réaction de polymérisation en chaîne.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections.
- virology : Coronavirus Infections, Respiratory System.
- Humans, Polymerase Chain Reaction, Viral Load.
Abstract
Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV).
DOI: 10.1093/infdis/jiu292
PubMed: 24837403
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Ziad A. Memish<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Saudi Aramco Medical Services Organization, Dhahran Indiana University School of Medicine, Indianapolis.</nlm:affiliation><wicri:noCountry code="subField">Indianapolis</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Prince Sultan Military Medical City.</nlm:affiliation><wicri:noCountry code="no comma">Prince Sultan Military Medical City.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pediatric Infectious Diseases, King Saud University, Riyadh.</nlm:affiliation><wicri:noCountry code="subField">Riyadh</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Special Infectious Diseases Agents Unit, King Fahad Medical Research Center, King Abdualziz University, Jeddah.</nlm:affiliation><wicri:noCountry code="subField">Jeddah</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation>Le document en format XML
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Alhakeem</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Albarrak, Ali" sort="Albarrak, Ali" uniqKey="Albarrak A" first="Ali" last="Albarrak">Ali Albarrak</name><affiliation><nlm:affiliation>Prince Sultan Military Medical City.</nlm:affiliation><wicri:noCountry code="no comma">Prince Sultan Military Medical City.</wicri:noCountry></affiliation></author><author><name sortKey="Alsubaie, Sarah" sort="Alsubaie, Sarah" uniqKey="Alsubaie S" first="Sarah" last="Alsubaie">Sarah Alsubaie</name><affiliation><nlm:affiliation>Pediatric Infectious Diseases, King Saud University, Riyadh.</nlm:affiliation><wicri:noCountry code="subField">Riyadh</wicri:noCountry></affiliation></author><author><name sortKey="Al Rabeeah, Abdullah A" sort="Al Rabeeah, Abdullah A" uniqKey="Al Rabeeah A" first="Abdullah A" last="Al-Rabeeah">Abdullah A. Al-Rabeeah</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Hajomar, Waleed H" sort="Hajomar, Waleed H" uniqKey="Hajomar W" first="Waleed H" last="Hajomar">Waleed H. Hajomar</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Hussain, Raheela" sort="Hussain, Raheela" uniqKey="Hussain R" first="Raheela" last="Hussain">Raheela Hussain</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Kheyami, Ali M" sort="Kheyami, Ali M" uniqKey="Kheyami A" first="Ali M" last="Kheyami">Ali M. Kheyami</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Almutairi, Abdullah" sort="Almutairi, Abdullah" uniqKey="Almutairi A" first="Abdullah" last="Almutairi">Abdullah Almutairi</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I" last="Azhar">Esam I. Azhar</name><affiliation><nlm:affiliation>Special Infectious Diseases Agents Unit, King Fahad Medical Research Center, King Abdualziz University, Jeddah.</nlm:affiliation><wicri:noCountry code="subField">Jeddah</wicri:noCountry></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Bonn Medical Center, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical Center</wicri:regionArea></affiliation></author><author><name sortKey="Watson, Simon J" sort="Watson, Simon J" uniqKey="Watson S" first="Simon J" last="Watson">Simon J. Watson</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Cotten, Matthew" sort="Cotten, Matthew" uniqKey="Cotten M" first="Matthew" last="Cotten">Matthew Cotten</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name><affiliation wicri:level="1"><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University, Division of Infection and Immunity, University College London (UCL), and UCL Hospitals National Health Service Foundation Trust, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University, Division of Infection and Immunity, University College London (UCL), and UCL Hospitals National Health Service Foundation Trust</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24837403</idno><idno type="pmid">24837403</idno><idno type="doi">10.1093/infdis/jiu292</idno><idno type="wicri:Area/PubMed/Corpus">001979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001979</idno><idno type="wicri:Area/PubMed/Curation">001979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001979</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome.</title><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:affiliation>Saudi Aramco Medical Services Organization, Dhahran Indiana University School of Medicine, Indianapolis.</nlm:affiliation><wicri:noCountry code="subField">Indianapolis</wicri:noCountry></affiliation></author><author><name sortKey="Makhdoom, Hatem Q" sort="Makhdoom, Hatem Q" uniqKey="Makhdoom H" first="Hatem Q" last="Makhdoom">Hatem Q. Makhdoom</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F" last="Alhakeem">Raafat F. Alhakeem</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Albarrak, Ali" sort="Albarrak, Ali" uniqKey="Albarrak A" first="Ali" last="Albarrak">Ali Albarrak</name><affiliation><nlm:affiliation>Prince Sultan Military Medical City.</nlm:affiliation><wicri:noCountry code="no comma">Prince Sultan Military Medical City.</wicri:noCountry></affiliation></author><author><name sortKey="Alsubaie, Sarah" sort="Alsubaie, Sarah" uniqKey="Alsubaie S" first="Sarah" last="Alsubaie">Sarah Alsubaie</name><affiliation><nlm:affiliation>Pediatric Infectious Diseases, King Saud University, Riyadh.</nlm:affiliation><wicri:noCountry code="subField">Riyadh</wicri:noCountry></affiliation></author><author><name sortKey="Al Rabeeah, Abdullah A" sort="Al Rabeeah, Abdullah A" uniqKey="Al Rabeeah A" first="Abdullah A" last="Al-Rabeeah">Abdullah A. Al-Rabeeah</name><affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</nlm:affiliation><wicri:noCountry code="subField">Alfaisal University</wicri:noCountry></affiliation></author><author><name sortKey="Hajomar, Waleed H" sort="Hajomar, Waleed H" uniqKey="Hajomar W" first="Waleed H" last="Hajomar">Waleed H. Hajomar</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Hussain, Raheela" sort="Hussain, Raheela" uniqKey="Hussain R" first="Raheela" last="Hussain">Raheela Hussain</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Kheyami, Ali M" sort="Kheyami, Ali M" uniqKey="Kheyami A" first="Ali M" last="Kheyami">Ali M. Kheyami</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Almutairi, Abdullah" sort="Almutairi, Abdullah" uniqKey="Almutairi A" first="Abdullah" last="Almutairi">Abdullah Almutairi</name><affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I" last="Azhar">Esam I. Azhar</name><affiliation><nlm:affiliation>Special Infectious Diseases Agents Unit, King Fahad Medical Research Center, King Abdualziz University, Jeddah.</nlm:affiliation><wicri:noCountry code="subField">Jeddah</wicri:noCountry></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Bonn Medical Center, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical Center</wicri:regionArea></affiliation></author><author><name sortKey="Watson, Simon J" sort="Watson, Simon J" uniqKey="Watson S" first="Simon J" last="Watson">Simon J. Watson</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Cotten, Matthew" sort="Cotten, Matthew" uniqKey="Cotten M" first="Matthew" last="Cotten">Matthew Cotten</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton.</nlm:affiliation><wicri:noCountry code="subField">Hinxton</wicri:noCountry></affiliation></author><author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name><affiliation wicri:level="1"><nlm:affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University, Division of Infection and Immunity, University College London (UCL), and UCL Hospitals National Health Service Foundation Trust, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University, Division of Infection and Immunity, University College London (UCL), and UCL Hospitals National Health Service Foundation Trust</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Polymerase Chain Reaction</term><term>Respiratory System (virology)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Appareil respiratoire (virologie)</term><term>Charge virale</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Réaction de polymérisation en chaîne</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Polymerase Chain Reaction</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term><term>Humains</term><term>Réaction de polymérisation en chaîne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24837403</PMID><DateCompleted><Year>2014</Year><Month>12</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>210</Volume><Issue>10</Issue><PubDate><Year>2014</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>1590-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiu292</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Respiratory tract samples from cases of MERS-CoV infection confirmed by polymerase chain reaction (PCR) were investigated to determine the MERS-CoV load and fraction of the MERS-CoV genome. These values were analyzed to determine associations with clinical sample type.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Samples from 112 individuals in which MERS-CoV was detected by PCR were analyzed, of which 13 were sputum samples, 64 were nasopharyngeal swab specimens, 30 were tracheal aspirates, and 3 were bronchoalveolar lavage specimens; 2 samples were of unknown origin. Tracheal aspirates yielded significantly higher MERS-CoV loads, compared with nasopharyngeal swab specimens (P = .005) and sputum specimens (P = .0001). Tracheal aspirates had viral loads similar to those in bronchoalveolar lavage samples (P = .3079). Bronchoalveolar lavage samples and tracheal aspirates had significantly higher genome fraction than nasopharyngeal swab specimens (P = .0095 and P = .0002, respectively) and sputum samples (P = .0009 and P = .0001, respectively). The genome yield from tracheal aspirates and bronchoalveolar lavage samples were similar (P = .1174).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Lower respiratory tract samples yield significantly higher MERS-CoV loads and genome fractions than upper respiratory tract samples.</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Memish</LastName><ForeName>Ziad A</ForeName><Initials>ZA</Initials><AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Tawfiq</LastName><ForeName>Jaffar A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Saudi Aramco Medical Services Organization, Dhahran Indiana University School of Medicine, Indianapolis.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makhdoom</LastName><ForeName>Hatem Q</ForeName><Initials>HQ</Initials><AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assiri</LastName><ForeName>Abdullah</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alhakeem</LastName><ForeName>Raafat F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albarrak</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Prince Sultan Military Medical City.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsubaie</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pediatric Infectious Diseases, King Saud University, Riyadh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Rabeeah</LastName><ForeName>Abdullah A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hajomar</LastName><ForeName>Waleed H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussain</LastName><ForeName>Raheela</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kheyami</LastName><ForeName>Ali M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almutairi</LastName><ForeName>Abdullah</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health Regional Laboratory, Ministry of Health, Madinah Regional Laboratory, Ministry of Health, Dammam, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azhar</LastName><ForeName>Esam I</ForeName><Initials>EI</Initials><AffiliationInfo><Affiliation>Special Infectious Diseases Agents Unit, King Fahad Medical Research Center, King Abdualziz University, Jeddah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drosten</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Center, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watson</LastName><ForeName>Simon J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kellam</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cotten</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zumla</LastName><ForeName>Alimuddin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University, Division of Infection and Immunity, University College London (UCL), and UCL Hospitals National Health Service Foundation Trust, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><Acronym>DH_</Acronym><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="Y">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ct value</Keyword><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">Middle East</Keyword><Keyword MajorTopicYN="N">RT-PCR</Keyword><Keyword MajorTopicYN="N">clinical</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">diagnosis</Keyword><Keyword MajorTopicYN="N">genome fraction</Keyword><Keyword MajorTopicYN="N">molecular</Keyword><Keyword MajorTopicYN="N">screening</Keyword><Keyword MajorTopicYN="N">viral load</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24837403</ArticleId><ArticleId IdType="pii">infdis/jiu292</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiu292</ArticleId><ArticleId IdType="pmc">PMC7107391</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Lancet. 2013 Dec 14;382(9909):1993-2002</Citation><ArticleIdList><ArticleId IdType="pubmed">24055451</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2014 Feb 18;5(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">24549846</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 May;10(5):825-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15200815</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Microbiol. 2009 Nov;47(11):3439-43</Citation><ArticleIdList><ArticleId IdType="pubmed">19726607</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2013 Jun 29;381(9885):2265-72</Citation><ArticleIdList><ArticleId IdType="pubmed">23727167</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):752-61</Citation><ArticleIdList><ArticleId IdType="pubmed">23891402</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Eur J Clin Microbiol Infect Dis. 2007 Feb;26(2):121-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17219094</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Clin Microbiol Infect. 2014 May;20(5):469-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24460984</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Euro Surveill. 2013 Feb 21;18(8):</Citation><ArticleIdList><ArticleId IdType="pubmed">23449231</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Infect Dis Clin North Am. 2010 Sep;24(3):619-38</Citation><ArticleIdList><ArticleId IdType="pubmed">20674795</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1012-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24857749</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Microbiol. 2009 Jan;47(1):21-31</Citation><ArticleIdList><ArticleId IdType="pubmed">19020070</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):745-51</Citation><ArticleIdList><ArticleId IdType="pubmed">23782859</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Euro Surveill. 2012 Sep 27;17(39):</Citation><ArticleIdList><ArticleId IdType="pubmed">23041020</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Crit Care. 2009;13(5):R148</Citation><ArticleIdList><ArticleId IdType="pubmed">19747383</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Euro Surveill. 2012 Oct 04;17(40):20290</Citation><ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chest. 2004 Aug;126(2):509-17</Citation><ArticleIdList><ArticleId IdType="pubmed">15302738</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Microbiol Immunol Infect. 2006 Feb;39(1):45-53</Citation><ArticleIdList><ArticleId IdType="pubmed">16440123</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation><ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Euro Surveill. 2013 Jun 13;18(24):</Citation><ArticleIdList><ArticleId IdType="pubmed">23787161</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Euro Surveill. 2012 Dec 06;17(49):</Citation><ArticleIdList><ArticleId IdType="pubmed">23231891</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Virol. 2010 Jan;82(1):1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19950247</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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