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Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.

Identifieur interne : 001844 ( PubMed/Curation ); précédent : 001843; suivant : 001845

Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.

Source :

Journal of Korean medical science [ 1598-6357 ] ; 2014.

RBID : pubmed:25246748

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Anesthésiques intraveineux (pharmacologie), Femelle, Fentanyl (pharmacologie), Humains, Imagerie par résonance magnétique, Indice de gravité médicale, Maladie de Parkinson (), Microélectrodes, Mâle, Noyau subthalamique (), Noyau subthalamique (physiologie), Propofol (pharmacologie), Stimulation cérébrale profonde, Sujet âgé, Tomodensitométrie, Électrodes implantées.
MESH :
- pharmacologie : Anesthésiques intraveineux, Fentanyl, Propofol.
- physiologie : Noyau subthalamique.
- Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Indice de gravité médicale, Maladie de Parkinson, Microélectrodes, Mâle, Noyau subthalamique, Stimulation cérébrale profonde, Sujet âgé, Tomodensitométrie, Électrodes implantées.

English descriptors

KwdEn :
- Aged, Anesthetics, Intravenous (pharmacology), Deep Brain Stimulation, Electrodes, Implanted, Female, Fentanyl (pharmacology), Humans, Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Parkinson Disease (prevention & control), Propofol (pharmacology), Severity of Illness Index, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiology), Tomography, X-Ray Computed.
MESH :
- chemical , pharmacology : Anesthetics, Intravenous, Fentanyl, Propofol.
- drug effects : Subthalamic Nucleus.
- physiology : Subthalamic Nucleus.
- prevention & control : Parkinson Disease.
- Aged, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Severity of Illness Index, Tomography, X-Ray Computed.

Abstract

We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7 ± 16.8 spikes/sec, n=78) and the right side MERs (35.5 ± 17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.

DOI: 10.3346/jkms.2014.29.9.1278
PubMed: 25246748

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<author><name sortKey="Kim, Han Joon" sort="Kim, Han Joon" uniqKey="Kim H" first="Han-Joon" last="Kim">Han-Joon Kim</name>
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<author><name sortKey="Kim, Hee Chan" sort="Kim, Hee Chan" uniqKey="Kim H" first="Hee Chan" last="Kim">Hee Chan Kim</name>
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<author><name sortKey="Kim, Dong Gyu" sort="Kim, Dong Gyu" uniqKey="Kim D" first="Dong Gyu" last="Kim">Dong Gyu Kim</name>
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<author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.</title>
<author><name sortKey="Kim, Wonki" sort="Kim, Wonki" uniqKey="Kim W" first="Wonki" last="Kim">Wonki Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Song, In Ho" sort="Song, In Ho" uniqKey="Song I" first="In Ho" last="Song">In Ho Song</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Device Development Center, Osong Medical Innovation Foundation, Cheongwon, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Medical Device Development Center, Osong Medical Innovation Foundation, Cheongwon</wicri:regionArea>
</affiliation>
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<author><name sortKey="Lim, Yong Hoon" sort="Lim, Yong Hoon" uniqKey="Lim Y" first="Yong Hoon" last="Lim">Yong Hoon Lim</name>
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<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
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<author><name sortKey="Kim, Mi Ryoung" sort="Kim, Mi Ryoung" uniqKey="Kim M" first="Mi-Ryoung" last="Kim">Mi-Ryoung Kim</name>
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<author><name sortKey="Kim, Young Eun" sort="Kim, Young Eun" uniqKey="Kim Y" first="Young Eun" last="Kim">Young Eun Kim</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Hwang, Jae Ha" sort="Hwang, Jae Ha" uniqKey="Hwang J" first="Jae Ha" last="Hwang">Jae Ha Hwang</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Song, Sang Woo" sort="Song, Sang Woo" uniqKey="Song S" first="Sang Woo" last="Song">Sang Woo Song</name>
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<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
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<author><name sortKey="Kim, Jin Wook" sort="Kim, Jin Wook" uniqKey="Kim J" first="Jin Wook" last="Kim">Jin Wook Kim</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Woong Woo" sort="Lee, Woong Woo" uniqKey="Lee W" first="Woong-Woo" last="Lee">Woong-Woo Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Han Joon" sort="Kim, Han Joon" uniqKey="Kim H" first="Han-Joon" last="Kim">Han-Joon Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Cheolyoung" sort="Kim, Cheolyoung" uniqKey="Kim C" first="Cheolyoung" last="Kim">Cheolyoung Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Imaging Laboratory and CyberMed, Inc., Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Medical Imaging Laboratory and CyberMed, Inc., Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Hee Chan" sort="Kim, Hee Chan" uniqKey="Kim H" first="Hee Chan" last="Kim">Hee Chan Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Engineering, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Medical Engineering, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, In Young" sort="Kim, In Young" uniqKey="Kim I" first="In Young" last="Kim">In Young Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering, Hanyang University, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biomedical Engineering, Hanyang University, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Hee Pyoung" sort="Park, Hee Pyoung" uniqKey="Park H" first="Hee Pyoung" last="Park">Hee Pyoung Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kim, Dong Gyu" sort="Kim, Dong Gyu" uniqKey="Kim D" first="Dong Gyu" last="Kim">Dong Gyu Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea. ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. ; Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea. ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. ; Clinical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea>
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<term>Anesthetics, Intravenous (pharmacology)</term>
<term>Deep Brain Stimulation</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Fentanyl (pharmacology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Parkinson Disease (prevention & control)</term>
<term>Propofol (pharmacology)</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (drug effects)</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
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<term>Anesthésiques intraveineux (pharmacologie)</term>
<term>Femelle</term>
<term>Fentanyl (pharmacologie)</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Indice de gravité médicale</term>
<term>Maladie de Parkinson ()</term>
<term>Microélectrodes</term>
<term>Mâle</term>
<term>Noyau subthalamique ()</term>
<term>Noyau subthalamique (physiologie)</term>
<term>Propofol (pharmacologie)</term>
<term>Stimulation cérébrale profonde</term>
<term>Sujet âgé</term>
<term>Tomodensitométrie</term>
<term>Électrodes implantées</term>
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<term>Fentanyl</term>
<term>Propofol</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
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<term>Propofol</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
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<term>Deep Brain Stimulation</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Indice de gravité médicale</term>
<term>Maladie de Parkinson</term>
<term>Microélectrodes</term>
<term>Mâle</term>
<term>Noyau subthalamique</term>
<term>Stimulation cérébrale profonde</term>
<term>Sujet âgé</term>
<term>Tomodensitométrie</term>
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<front><div type="abstract" xml:lang="en">We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7 ± 16.8 spikes/sec, n=78) and the right side MERs (35.5 ± 17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25246748</PMID>
<DateCompleted><Year>2015</Year>
<Month>05</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<Issue>9</Issue>
<PubDate><Year>2014</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of Korean medical science</Title>
<ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.</ArticleTitle>
<Pagination><MedlinePgn>1278-86</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2014.29.9.1278</ELocationID>
<Abstract><AbstractText>We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7 ± 16.8 spikes/sec, n=78) and the right side MERs (35.5 ± 17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Wonki</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">0000-0001-7197-2366</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>In Ho</ForeName>
<Initials>IH</Initials>
<Identifier Source="ORCID">0000-0001-6330-3453</Identifier>
<AffiliationInfo><Affiliation>Medical Device Development Center, Osong Medical Innovation Foundation, Cheongwon, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lim</LastName>
<ForeName>Yong Hoon</ForeName>
<Initials>YH</Initials>
<Identifier Source="ORCID">0000-0002-0346-2345</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Mi-Ryoung</ForeName>
<Initials>MR</Initials>
<Identifier Source="ORCID">0000-0003-0671-2263</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Young Eun</ForeName>
<Initials>YE</Initials>
<Identifier Source="ORCID">0000-0002-7182-6569</Identifier>
<AffiliationInfo><Affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Jae Ha</ForeName>
<Initials>JH</Initials>
<Identifier Source="ORCID">0000-0002-6455-3590</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>In Keyoung</ForeName>
<Initials>IK</Initials>
<Identifier Source="ORCID">0000-0002-7761-9456</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Sang Woo</ForeName>
<Initials>SW</Initials>
<Identifier Source="ORCID">0000-0002-5523-3798</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Jin Wook</ForeName>
<Initials>JW</Initials>
<Identifier Source="ORCID">0000-0002-3773-3940</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Woong-Woo</ForeName>
<Initials>WW</Initials>
<Identifier Source="ORCID">0000-0002-8767-7967</Identifier>
<AffiliationInfo><Affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Han-Joon</ForeName>
<Initials>HJ</Initials>
<Identifier Source="ORCID">0000-0001-8219-9663</Identifier>
<AffiliationInfo><Affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Cheolyoung</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">0000-0001-5586-9342</Identifier>
<AffiliationInfo><Affiliation>Medical Imaging Laboratory and CyberMed, Inc., Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hee Chan</ForeName>
<Initials>HC</Initials>
<Identifier Source="ORCID">0000-0002-2112-426X</Identifier>
<AffiliationInfo><Affiliation>Department of Medical Engineering, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>In Young</ForeName>
<Initials>IY</Initials>
<Identifier Source="ORCID">0000-0001-9580-7074</Identifier>
<AffiliationInfo><Affiliation>Department of Biomedical Engineering, Hanyang University, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Hee Pyoung</ForeName>
<Initials>HP</Initials>
<Identifier Source="ORCID">0000-0002-4772-0780</Identifier>
<AffiliationInfo><Affiliation>Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Dong Gyu</ForeName>
<Initials>DG</Initials>
<Identifier Source="ORCID">0000-0002-5740-6189</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeon</LastName>
<ForeName>Beom Seok</ForeName>
<Initials>BS</Initials>
<Identifier Source="ORCID">0000-0003-2491-3544</Identifier>
<AffiliationInfo><Affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paek</LastName>
<ForeName>Sun Ha</ForeName>
<Initials>SH</Initials>
<Identifier Source="ORCID">0000-0003-3007-8653</Identifier>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. ; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea. ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. ; Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>09</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Korea (South)</Country>
<MedlineTA>J Korean Med Sci</MedlineTA>
<NlmUniqueID>8703518</NlmUniqueID>
<ISSNLinking>1011-8934</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018686">Anesthetics, Intravenous</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>UF599785JZ</RegistryNumber>
<NameOfSubstance UI="D005283">Fentanyl</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>YI7VU623SF</RegistryNumber>
<NameOfSubstance UI="D015742">Propofol</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018686" MajorTopicYN="N">Anesthetics, Intravenous</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046690" MajorTopicYN="Y">Deep Brain Stimulation</DescriptorName>
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<MeshHeading><DescriptorName UI="D004567" MajorTopicYN="N">Electrodes, Implanted</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005283" MajorTopicYN="N">Fentanyl</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008839" MajorTopicYN="N">Microelectrodes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015742" MajorTopicYN="N">Propofol</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Deep Brain Stimulation</Keyword>
<Keyword MajorTopicYN="N">Fentanyl</Keyword>
<Keyword MajorTopicYN="N">Microelectrodes</Keyword>
<Keyword MajorTopicYN="N">Parkinson Disease</Keyword>
<Keyword MajorTopicYN="N">Propofol</Keyword>
<Keyword MajorTopicYN="N">Subthalamic Nucleus</Keyword>
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Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.

Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.

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