Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants.
Identifieur interne : 001291 ( PubMed/Curation ); précédent : 001290; suivant : 001292Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants.
Auteurs : Monica K. Borucki [États-Unis] ; Victoria Lao [États-Unis] ; Mona Hwang [États-Unis] ; Shea Gardner [États-Unis] ; Danielle Adney [États-Unis] ; Vincent Munster [États-Unis] ; Richard Bowen [États-Unis] ; Jonathan E. Allen [États-Unis]Source :
- PloS one [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- transmission : Animaux, Cellules Vero, Chameaux, Humains, Infections à coronavirus, Mutation.
English descriptors
- KwdEn :
- MESH :
- genetics : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- Animals, Camelus, Chlorocebus aethiops, Humans, Mutation, Vero Cells.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen related to SARS virus. In vitro studies indicate this virus may have a broad host range suggesting an increased pandemic potential. Genetic and epidemiological evidence indicate camels serve as a reservoir for MERS virus but the mechanism of cross species transmission is unclear and many questions remain regarding the susceptibility of humans to infection. Deep sequencing data was obtained from the nasal samples of three camels that had been experimentally infected with a human MERS-CoV isolate. A majority of the genome was covered and average coverage was greater than 12,000x depth. Although only 5 mutations were detected in the consensus sequences, 473 intrahost single nucleotide variants were identified. Many of these variants were present at high frequencies and could potentially influence viral phenotype and the sensitivity of detection assays that target these regions for primer or probe binding.
DOI: 10.1371/journal.pone.0146251
PubMed: 26790002
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001291
Links to Exploration step
pubmed:26790002Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants.</title>
<author><name sortKey="Borucki, Monica K" sort="Borucki, Monica K" uniqKey="Borucki M" first="Monica K" last="Borucki">Monica K. Borucki</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lao, Victoria" sort="Lao, Victoria" uniqKey="Lao V" first="Victoria" last="Lao">Victoria Lao</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hwang, Mona" sort="Hwang, Mona" uniqKey="Hwang M" first="Mona" last="Hwang">Mona Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gardner, Shea" sort="Gardner, Shea" uniqKey="Gardner S" first="Shea" last="Gardner">Shea Gardner</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adney, Danielle" sort="Adney, Danielle" uniqKey="Adney D" first="Danielle" last="Adney">Danielle Adney</name>
<affiliation wicri:level="1"><nlm:affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Colorado State University, Fort Collins, Colorado</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent" sort="Munster, Vincent" uniqKey="Munster V" first="Vincent" last="Munster">Vincent Munster</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bowen, Richard" sort="Bowen, Richard" uniqKey="Bowen R" first="Richard" last="Bowen">Richard Bowen</name>
<affiliation wicri:level="1"><nlm:affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Colorado State University, Fort Collins, Colorado</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allen, Jonathan E" sort="Allen, Jonathan E" uniqKey="Allen J" first="Jonathan E" last="Allen">Jonathan E. Allen</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26790002</idno>
<idno type="pmid">26790002</idno>
<idno type="doi">10.1371/journal.pone.0146251</idno>
<idno type="wicri:Area/PubMed/Corpus">001291</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001291</idno>
<idno type="wicri:Area/PubMed/Curation">001291</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001291</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants.</title>
<author><name sortKey="Borucki, Monica K" sort="Borucki, Monica K" uniqKey="Borucki M" first="Monica K" last="Borucki">Monica K. Borucki</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lao, Victoria" sort="Lao, Victoria" uniqKey="Lao V" first="Victoria" last="Lao">Victoria Lao</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hwang, Mona" sort="Hwang, Mona" uniqKey="Hwang M" first="Mona" last="Hwang">Mona Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gardner, Shea" sort="Gardner, Shea" uniqKey="Gardner S" first="Shea" last="Gardner">Shea Gardner</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adney, Danielle" sort="Adney, Danielle" uniqKey="Adney D" first="Danielle" last="Adney">Danielle Adney</name>
<affiliation wicri:level="1"><nlm:affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Colorado State University, Fort Collins, Colorado</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent" sort="Munster, Vincent" uniqKey="Munster V" first="Vincent" last="Munster">Vincent Munster</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bowen, Richard" sort="Bowen, Richard" uniqKey="Bowen R" first="Richard" last="Bowen">Richard Bowen</name>
<affiliation wicri:level="1"><nlm:affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Colorado State University, Fort Collins, Colorado</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allen, Jonathan E" sort="Allen, Jonathan E" uniqKey="Allen J" first="Jonathan E" last="Allen">Jonathan E. Allen</name>
<affiliation wicri:level="1"><nlm:affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lawrence Livermore National Laboratory, Livermore, California</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Camelus</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Mutation</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Humains</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Camelus</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Mutation</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Chameaux</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Mutation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen related to SARS virus. In vitro studies indicate this virus may have a broad host range suggesting an increased pandemic potential. Genetic and epidemiological evidence indicate camels serve as a reservoir for MERS virus but the mechanism of cross species transmission is unclear and many questions remain regarding the susceptibility of humans to infection. Deep sequencing data was obtained from the nasal samples of three camels that had been experimentally infected with a human MERS-CoV isolate. A majority of the genome was covered and average coverage was greater than 12,000x depth. Although only 5 mutations were detected in the consensus sequences, 473 intrahost single nucleotide variants were identified. Many of these variants were present at high frequencies and could potentially influence viral phenotype and the sensitivity of detection assays that target these regions for primer or probe binding. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26790002</PMID>
<DateCompleted><Year>2016</Year>
<Month>07</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants.</ArticleTitle>
<Pagination><MedlinePgn>e0146251</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0146251</ELocationID>
<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen related to SARS virus. In vitro studies indicate this virus may have a broad host range suggesting an increased pandemic potential. Genetic and epidemiological evidence indicate camels serve as a reservoir for MERS virus but the mechanism of cross species transmission is unclear and many questions remain regarding the susceptibility of humans to infection. Deep sequencing data was obtained from the nasal samples of three camels that had been experimentally infected with a human MERS-CoV isolate. A majority of the genome was covered and average coverage was greater than 12,000x depth. Although only 5 mutations were detected in the consensus sequences, 473 intrahost single nucleotide variants were identified. Many of these variants were present at high frequencies and could potentially influence viral phenotype and the sensitivity of detection assays that target these regions for primer or probe binding. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Borucki</LastName>
<ForeName>Monica K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lao</LastName>
<ForeName>Victoria</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Mona</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gardner</LastName>
<ForeName>Shea</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adney</LastName>
<ForeName>Danielle</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Munster</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bowen</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Colorado State University, Fort Collins, Colorado, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allen</LastName>
<ForeName>Jonathan E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Lawrence Livermore National Laboratory, Livermore, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>S10 RR027303</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10 RR029668</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10RR027303</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10RR029668</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>PLoS One. 2016;11(4):e0154424</RefSource>
<PMID Version="1">27111439</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002162" MajorTopicYN="N">Camelus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>09</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>12</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>1</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>1</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>7</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26790002</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0146251</ArticleId>
<ArticleId IdType="pii">PONE-D-15-39850</ArticleId>
<ArticleId IdType="pmc">PMC4720378</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Dec;20(12):1999-2005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25418529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Mar;88(5):2623-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24352442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Announc. 2014 May 29;2(3):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24874668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2015 Apr 16;202:60-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25656066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012;17(40):20290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Genet Evol. 2012 Aug;12(6):1305-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22609285</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Bioinformatics. 2014;2014:101894</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25157264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Curr. 2013 Nov 13;5:null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24270586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2014 Apr 1;209(7):995-1006</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24253287</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2018-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778221</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2004 Mar 25;350(13):1366-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15044654</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Nov;79(21):13285-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16227251</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012;3(6). pii: e00473-12. doi: 10.1128/mBio.00473-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Genomics. 2013;14:96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23402258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Virus Res. 1991;40:181-211</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1957718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2014;5:3067</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24473083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2014 Aug;6(8):2991-3018</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25105276</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2014 Dec;10(12):e1004529</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25502394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2006 Nov;87(Pt 11):3349-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17030869</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24043791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2006 Oct 3;45(39):11827-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17002283</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2006 Jan 13;311(5758):236-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16410525</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2013 May;19(5):736-42B</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23693015</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2014 Sep 12;289(37):25783-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25074927</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2013 Oct;13(10):859-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23933067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2011 Apr 1;27(7):1011-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21278192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1319-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25075637</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Bioinformatics. 2011;12:210</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21615913</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012;17(49). pii: 20334</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23231891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013;8(1):e52752</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23308119</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jun;87(11):6296-305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23536667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3484-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19208801</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014;5(3):e01146-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24781747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathog. 2012;2012:738590</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23097708</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genomics Proteomics Bioinformatics. 2006 Nov;4(4):259-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17531802</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2014 Mar;103:39-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24418573</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001291 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001291 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:26790002 |texte= Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:26790002" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |