Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.
Identifieur interne : 001016 ( PubMed/Curation ); précédent : 001015; suivant : 001017Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.
Auteurs : Xiaoyan Lu [Géorgie (pays)] ; Lori A. Rowe [Géorgie (pays)] ; Michael Frace [Géorgie (pays)] ; James Stevens [Géorgie (pays)] ; Glen R. Abedi [Géorgie (pays)] ; Osman Elnile [Arabie saoudite] ; Taleb Banassir [Arabie saoudite] ; Malak Al-Masri [Arabie saoudite] ; John T. Watson [Géorgie (pays)] ; Abdullah Assiri [Arabie saoudite] ; Dean D. Erdman [Géorgie (pays)]Source :
- Journal of medical virology [ 1096-9071 ] ; 2017.
Descripteurs français
- KwdFr :
- Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Délétion de séquence, Flambées de maladies, Glycoprotéine de spicule des coronavirus (génétique), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Sérum (virologie), Variation génétique.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus, Sérum.
- épidémiologie : Arabie saoudite, Infections à coronavirus.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Délétion de séquence, Flambées de maladies, Humains, Variation génétique.
English descriptors
- KwdEn :
- Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Disease Outbreaks, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Saudi Arabia (epidemiology), Sequence Deletion, Serum (virology), Spike Glycoprotein, Coronavirus (genetics).
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- epidemiology : Coronavirus Infections, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Serum.
- Disease Outbreaks, Genetic Variation, Humans, Sequence Deletion.
Abstract
The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc.
DOI: 10.1002/jmv.24652
PubMed: 27486688
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pubmed:27486688Le document en format XML
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<front><div type="abstract" xml:lang="en">The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc.</div>
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