Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus.
Identifieur interne : 000910 ( PubMed/Curation ); précédent : 000909; suivant : 000911Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus.
Auteurs : Seo-Yeon Jung [Corée du Sud] ; Kyung Won Kang [Corée du Sud] ; Eun-Young Lee [Corée du Sud] ; Dong-Won Seo [Corée du Sud] ; Hong-Lim Kim [Corée du Sud] ; Hak Kim [Corée du Sud] ; Taewoo Kwon [Corée du Sud] ; Hye-Lim Park [Corée du Sud] ; Hun Kim [Corée du Sud] ; Sang-Myeong Lee [Corée du Sud] ; Jae-Hwan Nam [Corée du Sud]Source :
- Vaccine [ 1873-2518 ] ; 2018.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (), Adjuvants immunologiques (administration et posologie), Adénovirus humains (génétique), Adénovirus humains (immunologie), Alun (administration et posologie), Animaux, Anticorps antiviraux (biosynthèse), Anticorps neutralisants (biosynthèse), Calendrier vaccinal, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Glycoprotéine de spicule des coronavirus (administration et posologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline G (biosynthèse), Immunogénicité des vaccins, Infections à coronavirus (), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Lymphocytes auxiliaires Th1 (), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th1 (virologie), Lymphocytes auxiliaires Th2 (), Lymphocytes auxiliaires Th2 (immunologie), Lymphocytes auxiliaires Th2 (virologie), Nanoparticules (), Nanoparticules (administration et posologie), Rappel de vaccin (), Souris, Souris de lignée BALB C, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Alun, Glycoprotéine de spicule des coronavirus, Nanoparticules, Vaccins antiviraux.
- biosynthèse : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- génétique : Adénovirus humains, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Adénovirus humains, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Vaccins antiviraux.
- virologie : Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- Activation des lymphocytes, Animaux, Calendrier vaccinal, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Immunogénicité des vaccins, Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Nanoparticules, Rappel de vaccin, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Adenoviruses, Human (genetics), Adenoviruses, Human (immunology), Adjuvants, Immunologic (administration & dosage), Alum Compounds (administration & dosage), Animals, Antibodies, Neutralizing (biosynthesis), Antibodies, Viral (biosynthesis), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Female, Humans, Immunization Schedule, Immunization, Secondary (methods), Immunogenicity, Vaccine, Immunoglobulin G (biosynthesis), Lymphocyte Activation (drug effects), Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Nanoparticles (administration & dosage), Nanoparticles (chemistry), Spike Glycoprotein, Coronavirus (administration & dosage), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Th1 Cells (drug effects), Th1 Cells (immunology), Th1 Cells (virology), Th2 Cells (drug effects), Th2 Cells (immunology), Th2 Cells (virology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Alum Compounds, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- chemical , biosynthesis : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- administration & dosage : Nanoparticles.
- chemistry : Nanoparticles.
- drug effects : Lymphocyte Activation, Middle East Respiratory Syndrome Coronavirus, Th1 Cells, Th2 Cells.
- genetics : Adenoviruses, Human, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : Adenoviruses, Human, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Th1 Cells, Th2 Cells, Viral Vaccines.
- methods : Immunization, Secondary.
- prevention & control : Coronavirus Infections.
- virology : Coronavirus Infections, Th1 Cells, Th2 Cells.
- Animals, Female, Humans, Immunization Schedule, Immunogenicity, Vaccine, Mice, Mice, Inbred BALB C.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS. Although both types of vaccine could induce specific immunoglobulin G against MERS-CoV, neutralizing antibodies against MERS-CoV were induced only by heterologous prime-boost immunization and homologous immunization with spike protein nanoparticles. Interestingly, Th1 cell activation was induced by immunization schedules including Ad5/MERS, but not by those including only spike protein nanoparticles. Heterologous prime-boost vaccination regimens including Ad5/MERS elicited simultaneous Th1 and Th2 responses, but homologous prime-boost regimens did not. Thus, heterologous prime-boost may induce longer-lasting immune responses against MERS-CoV because of an appropriate balance of Th1/Th2 responses. However, both heterologous prime-boost and homologous spike protein nanoparticles vaccinations could provide protection from MERS-CoV challenge in mice. Our results demonstrate that heterologous immunization by priming with Ad5/MERS and boosting with spike protein nanoparticles could be an efficient prophylactic strategy against MERS-CoV infection.
DOI: 10.1016/j.vaccine.2018.04.082
PubMed: 29739720
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviruses, Human (genetics)</term>
<term>Adenoviruses, Human (immunology)</term>
<term>Adjuvants, Immunologic (administration & dosage)</term>
<term>Alum Compounds (administration & dosage)</term>
<term>Animals</term>
<term>Antibodies, Neutralizing (biosynthesis)</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunization Schedule</term>
<term>Immunization, Secondary (methods)</term>
<term>Immunogenicity, Vaccine</term>
<term>Immunoglobulin G (biosynthesis)</term>
<term>Lymphocyte Activation (drug effects)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Nanoparticles (administration & dosage)</term>
<term>Nanoparticles (chemistry)</term>
<term>Spike Glycoprotein, Coronavirus (administration & dosage)</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Th1 Cells (drug effects)</term>
<term>Th1 Cells (immunology)</term>
<term>Th1 Cells (virology)</term>
<term>Th2 Cells (drug effects)</term>
<term>Th2 Cells (immunology)</term>
<term>Th2 Cells (virology)</term>
<term>Viral Vaccines (administration & dosage)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes ()</term>
<term>Adjuvants immunologiques (administration et posologie)</term>
<term>Adénovirus humains (génétique)</term>
<term>Adénovirus humains (immunologie)</term>
<term>Alun (administration et posologie)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Anticorps neutralisants (biosynthèse)</term>
<term>Calendrier vaccinal</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Femelle</term>
<term>Glycoprotéine de spicule des coronavirus (administration et posologie)</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains</term>
<term>Immunoglobuline G (biosynthèse)</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Lymphocytes auxiliaires Th1 ()</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (virologie)</term>
<term>Lymphocytes auxiliaires Th2 ()</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (virologie)</term>
<term>Nanoparticules ()</term>
<term>Nanoparticules (administration et posologie)</term>
<term>Rappel de vaccin ()</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaccins antiviraux (administration et posologie)</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term>
<term>Alum Compounds</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term>
<term>Alun</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Nanoparticules</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphocyte Activation</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviruses, Human</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénovirus humains</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adénovirus humains</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviruses, Human</term>
<term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Humans</term>
<term>Immunization Schedule</term>
<term>Immunogenicity, Vaccine</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Calendrier vaccinal</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Nanoparticules</term>
<term>Rappel de vaccin</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<front><div type="abstract" xml:lang="en">The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS. Although both types of vaccine could induce specific immunoglobulin G against MERS-CoV, neutralizing antibodies against MERS-CoV were induced only by heterologous prime-boost immunization and homologous immunization with spike protein nanoparticles. Interestingly, Th1 cell activation was induced by immunization schedules including Ad5/MERS, but not by those including only spike protein nanoparticles. Heterologous prime-boost vaccination regimens including Ad5/MERS elicited simultaneous Th1 and Th2 responses, but homologous prime-boost regimens did not. Thus, heterologous prime-boost may induce longer-lasting immune responses against MERS-CoV because of an appropriate balance of Th1/Th2 responses. However, both heterologous prime-boost and homologous spike protein nanoparticles vaccinations could provide protection from MERS-CoV challenge in mice. Our results demonstrate that heterologous immunization by priming with Ad5/MERS and boosting with spike protein nanoparticles could be an efficient prophylactic strategy against MERS-CoV infection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29739720</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>36</Volume>
<Issue>24</Issue>
<PubDate><Year>2018</Year>
<Month>06</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>Vaccine</Title>
<ISOAbbreviation>Vaccine</ISOAbbreviation>
</Journal>
<ArticleTitle>Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>3468-3476</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0264-410X(18)30598-X</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2018.04.082</ELocationID>
<Abstract><AbstractText>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS. Although both types of vaccine could induce specific immunoglobulin G against MERS-CoV, neutralizing antibodies against MERS-CoV were induced only by heterologous prime-boost immunization and homologous immunization with spike protein nanoparticles. Interestingly, Th1 cell activation was induced by immunization schedules including Ad5/MERS, but not by those including only spike protein nanoparticles. Heterologous prime-boost vaccination regimens including Ad5/MERS elicited simultaneous Th1 and Th2 responses, but homologous prime-boost regimens did not. Thus, heterologous prime-boost may induce longer-lasting immune responses against MERS-CoV because of an appropriate balance of Th1/Th2 responses. However, both heterologous prime-boost and homologous spike protein nanoparticles vaccinations could provide protection from MERS-CoV challenge in mice. Our results demonstrate that heterologous immunization by priming with Ad5/MERS and boosting with spike protein nanoparticles could be an efficient prophylactic strategy against MERS-CoV infection.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jung</LastName>
<ForeName>Seo-Yeon</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Kyung Won</ForeName>
<Initials>KW</Initials>
<AffiliationInfo><Affiliation>Division of Biotechnology, Chonbuk National University, Iksan 570-752, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Eun-Young</ForeName>
<Initials>EY</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seo</LastName>
<ForeName>Dong-Won</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Division of Biotechnology, Chonbuk National University, Iksan 570-752, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hong-Lim</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Seoul St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hak</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kwon</LastName>
<ForeName>TaeWoo</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Hye-Lim</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hun</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Sang-Myeong</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Division of Biotechnology, Chonbuk National University, Iksan 570-752, Republic of Korea. Electronic address: leesangm@jbnu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nam</LastName>
<ForeName>Jae-Hwan</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea. Electronic address: jhnam@catholic.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>05</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
<NlmUniqueID>8406899</NlmUniqueID>
<ISSNLinking>0264-410X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000276">Adjuvants, Immunologic</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000534">Alum Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000260" MajorTopicYN="N">Adenoviruses, Human</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000276" MajorTopicYN="N">Adjuvants, Immunologic</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000534" MajorTopicYN="N">Alum Compounds</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007115" MajorTopicYN="N">Immunization Schedule</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007117" MajorTopicYN="N">Immunization, Secondary</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071497" MajorTopicYN="N">Immunogenicity, Vaccine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018417" MajorTopicYN="N">Th1 Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018418" MajorTopicYN="N">Th2 Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Adenovirus 5</Keyword>
<Keyword MajorTopicYN="Y">Heterologous prime–boost</Keyword>
<Keyword MajorTopicYN="Y">MERS-CoV</Keyword>
<Keyword MajorTopicYN="Y">Th1</Keyword>
<Keyword MajorTopicYN="Y">Th2</Keyword>
<Keyword MajorTopicYN="Y">Vaccine</Keyword>
</KeywordList>
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<Day>28</Day>
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<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>04</Month>
<Day>25</Day>
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<Day>27</Day>
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