MersV1, PubMed, Corpus, bibRecord, 002654

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Identifieur interne : 002654 ( PubMed/Corpus ); précédent : 002653; suivant : 002655

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Auteurs : A. Kittaka ; T. Kuze ; T. Asakura ; K. Ito ; T. Miyasaka ; J. Inoue

Source :

Bioorganic & medicinal chemistry letters [ 0960-894X ] ; 1998.

RBID : pubmed:9873704

English descriptors

KwdEn :
- DNA (metabolism), Dimerization, NF-kappa B (metabolism), Oligonucleotides (metabolism), Uridine (analogs & derivatives), Uridine (metabolism).
MESH :
- chemical , analogs & derivatives : Uridine.
- chemical , metabolism : DNA, NF-kappa B, Oligonucleotides, Uridine.
- Dimerization.

Abstract

5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.

DOI: 10.1016/s0960-894x(98)00584-8
PubMed: 9873704

Links to Exploration step

pubmed:9873704

Le document en format XML

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<author><name sortKey="Kittaka, A" sort="Kittaka, A" uniqKey="Kittaka A" first="A" last="Kittaka">A. Kittaka</name>
<affiliation><nlm:affiliation>School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kuze, T" sort="Kuze, T" uniqKey="Kuze T" first="T" last="Kuze">T. Kuze</name>
</author>
<author><name sortKey="Asakura, T" sort="Asakura, T" uniqKey="Asakura T" first="T" last="Asakura">T. Asakura</name>
</author>
<author><name sortKey="Ito, K" sort="Ito, K" uniqKey="Ito K" first="K" last="Ito">K. Ito</name>
</author>
<author><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name>
</author>
<author><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. Inoue</name>
</author>
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<author><name sortKey="Kittaka, A" sort="Kittaka, A" uniqKey="Kittaka A" first="A" last="Kittaka">A. Kittaka</name>
<affiliation><nlm:affiliation>School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kuze, T" sort="Kuze, T" uniqKey="Kuze T" first="T" last="Kuze">T. Kuze</name>
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<author><name sortKey="Asakura, T" sort="Asakura, T" uniqKey="Asakura T" first="T" last="Asakura">T. Asakura</name>
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<author><name sortKey="Ito, K" sort="Ito, K" uniqKey="Ito K" first="K" last="Ito">K. Ito</name>
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<author><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name>
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<author><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. Inoue</name>
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<series><title level="j">Bioorganic & medicinal chemistry letters</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA (metabolism)</term>
<term>Dimerization</term>
<term>NF-kappa B (metabolism)</term>
<term>Oligonucleotides (metabolism)</term>
<term>Uridine (analogs & derivatives)</term>
<term>Uridine (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Uridine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA</term>
<term>NF-kappa B</term>
<term>Oligonucleotides</term>
<term>Uridine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Dimerization</term>
</keywords>
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<front><div type="abstract" xml:lang="en">5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9873704</PMID>
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<Month>01</Month>
<Day>26</Day>
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<DateRevised><Year>2019</Year>
<Month>08</Month>
<Day>19</Day>
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<JournalIssue CitedMedium="Print"><Volume>8</Volume>
<Issue>22</Issue>
<PubDate><Year>1998</Year>
<Month>Nov</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Bioorganic & medicinal chemistry letters</Title>
<ISOAbbreviation>Bioorg. Med. Chem. Lett.</ISOAbbreviation>
</Journal>
<ArticleTitle>Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.</ArticleTitle>
<Pagination><MedlinePgn>3207-10</MedlinePgn>
</Pagination>
<Abstract><AbstractText>5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.</AbstractText>
</Abstract>
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<Language>eng</Language>
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<ISSNLinking>0960-894X</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C116648">5-formyl-2'-O-methyluridine</NameOfSubstance>
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<MeshHeading><DescriptorName UI="D019281" MajorTopicYN="N">Dimerization</DescriptorName>
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<MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D009841" MajorTopicYN="N">Oligonucleotides</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D014529" MajorTopicYN="N">Uridine</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year>
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Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki