MersV1, PubMed, Corpus, bibRecord, 001950

A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design.

Identifieur interne : 001950 ( PubMed/Corpus ); précédent : 001949; suivant : 001951

A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design.

Auteurs : Refat Sharmin ; Abul Bashar Mir Md Khademul Islam

Source :

BMC bioinformatics [ 1471-2105 ] ; 2014.

RBID : pubmed:24884408

English descriptors

KwdEn :
- Algorithms, Amino Acid Sequence, Conserved Sequence, Coronavirus (enzymology), Coronavirus (immunology), Epitopes (chemistry), Humans, RNA Replicase (chemistry), RNA Replicase (immunology), Sequence Alignment, Viral Proteins (chemistry), Viral Proteins (immunology), Viral Vaccines.
MESH :
- chemical , chemistry : Epitopes, RNA Replicase, Viral Proteins.
- enzymology : Coronavirus.
- immunology : Coronavirus, RNA Replicase, Viral Proteins.
- Algorithms, Amino Acid Sequence, Conserved Sequence, Humans, Sequence Alignment, Viral Vaccines.

Abstract

Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine for all strain could be a promising solution in this circumstance. In this study we aimed to design an epitope based vaccine against all strain of human coronavirus.

DOI: 10.1186/1471-2105-15-161
PubMed: 24884408

Links to Exploration step

pubmed:24884408

Le document en format XML

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<author><name sortKey="Sharmin, Refat" sort="Sharmin, Refat" uniqKey="Sharmin R" first="Refat" last="Sharmin">Refat Sharmin</name>
</author>
<author><name sortKey="Islam, Abul Bashar Mir Md Khademul" sort="Islam, Abul Bashar Mir Md Khademul" uniqKey="Islam A" first="Abul Bashar Mir Md Khademul" last="Islam">Abul Bashar Mir Md Khademul Islam</name>
<affiliation><nlm:affiliation>Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka 1000, Bangladesh. khademul@du.ac.bd.</nlm:affiliation>
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<author><name sortKey="Islam, Abul Bashar Mir Md Khademul" sort="Islam, Abul Bashar Mir Md Khademul" uniqKey="Islam A" first="Abul Bashar Mir Md Khademul" last="Islam">Abul Bashar Mir Md Khademul Islam</name>
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<term>Amino Acid Sequence</term>
<term>Conserved Sequence</term>
<term>Coronavirus (enzymology)</term>
<term>Coronavirus (immunology)</term>
<term>Epitopes (chemistry)</term>
<term>Humans</term>
<term>RNA Replicase (chemistry)</term>
<term>RNA Replicase (immunology)</term>
<term>Sequence Alignment</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (immunology)</term>
<term>Viral Vaccines</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronavirus</term>
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<term>Amino Acid Sequence</term>
<term>Conserved Sequence</term>
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<front><div type="abstract" xml:lang="en">Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine for all strain could be a promising solution in this circumstance. In this study we aimed to design an epitope based vaccine against all strain of human coronavirus.</div>
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<Title>BMC bioinformatics</Title>
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<ArticleTitle>A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine for all strain could be a promising solution in this circumstance. In this study we aimed to design an epitope based vaccine against all strain of human coronavirus.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Multiple sequence alignment (MSA) approach was employed among spike (S), membrane (M), enveloped (E) and nucleocapsid (N) protein and replicase polyprotein 1ab to identify which one is highly conserve in all coronaviruses strains. Next, we use various in silico tools to predict consensus immunogenic and conserved peptide. We found that conserved region is present only in the RNA directed RNA polymerase protein. In this protein we identified one epitope WDYPKCDRA is highly immunogenic and 100% conserved among all available human coronavirus strains.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Here we suggest in vivo study of our identified novel peptide antigen in RNA directed RNA polymerase protein for universal vaccine--which may be the way to prevent all human coronavirus disease.</AbstractText>
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<ForeName>Abul Bashar Mir Md Khademul</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Department of Genetic Engineering and Biotechnology, University of Dhaka, Science Complex Building, Dhaka 1000, Bangladesh. khademul@du.ac.bd.</Affiliation>
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A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design.

A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki