Plants as Factories for Human Pharmaceuticals: Applications and Challenges.
Identifieur interne : 001357 ( PubMed/Corpus ); précédent : 001356; suivant : 001358Plants as Factories for Human Pharmaceuticals: Applications and Challenges.
Auteurs : Jian Yao ; Yunqi Weng ; Alexia Dickey ; Kevin Yueju WangSource :
- International journal of molecular sciences [ 1422-0067 ] ; 2015.
English descriptors
- KwdEn :
- Batch Cell Culture Techniques, Bioreactors, Biotechnology, Genetic Engineering, Glycosylation, Humans, Medicine, Traditional (methods), Plant Cells, Plant Preparations (chemistry), Plant Preparations (isolation & purification), Plant Preparations (pharmacology), Plant Preparations (therapeutic use), Plants, Genetically Modified, Plants, Medicinal (chemistry), Plants, Medicinal (genetics), Plants, Medicinal (metabolism), Polysaccharides (metabolism).
- MESH :
- chemical , chemistry : Plant Preparations.
- chemical , isolation & purification : Plant Preparations.
- chemistry : Plants, Medicinal.
- genetics : Plants, Medicinal.
- metabolism : Plants, Medicinal, Polysaccharides.
- methods : Medicine, Traditional.
- chemical , pharmacology : Plant Preparations.
- chemical , therapeutic use : Plant Preparations.
- Batch Cell Culture Techniques, Bioreactors, Biotechnology, Genetic Engineering, Glycosylation, Humans, Plant Cells, Plants, Genetically Modified.
Abstract
Plant molecular farming (PMF), defined as the practice of using plants to produce human therapeutic proteins, has received worldwide interest. PMF has grown and advanced considerably over the past two decades. A number of therapeutic proteins have been produced in plants, some of which have been through pre-clinical or clinical trials and are close to commercialization. Plants have the potential to mass-produce pharmaceutical products with less cost than traditional methods. Tobacco-derived antibodies have been tested and used to combat the Ebola outbreak in Africa. Genetically engineered immunoadhesin (DPP4-Fc) produced in green plants has been shown to be able to bind to MERS-CoV (Middle East Respiratory Syndrome), preventing the virus from infecting lung cells. Biosafety concerns (such as pollen contamination and immunogenicity of plant-specific glycans) and costly downstream extraction and purification requirements, however, have hampered PMF production from moving from the laboratory to industrial application. In this review, the challenges and opportunities of PMF are discussed. Topics addressed include; transformation and expression systems, plant bioreactors, safety concerns, and various opportunities to produce topical applications and health supplements.
DOI: 10.3390/ijms161226122
PubMed: 26633378
Links to Exploration step
pubmed:26633378Le document en format XML
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dickey@nsuok.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Kevin Yueju" sort="Wang, Kevin Yueju" uniqKey="Wang K" first="Kevin Yueju" last="Wang">Kevin Yueju Wang</name><affiliation><nlm:affiliation>Department of Natural Sciences Northeastern State University at Broken Arrow, Broken Arrow, OK 74014, USA. wang03@nsuok.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26633378</idno><idno type="pmid">26633378</idno><idno type="doi">10.3390/ijms161226122</idno><idno type="wicri:Area/PubMed/Corpus">001357</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001357</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plants as Factories for Human Pharmaceuticals: Applications and Challenges.</title><author><name sortKey="Yao, Jian" sort="Yao, Jian" uniqKey="Yao J" first="Jian" last="Yao">Jian Yao</name><affiliation><nlm:affiliation>Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. yaojian2002@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Weng, Yunqi" sort="Weng, Yunqi" uniqKey="Weng Y" first="Yunqi" last="Weng">Yunqi Weng</name><affiliation><nlm:affiliation>Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. wengyunqi@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Dickey, Alexia" sort="Dickey, Alexia" uniqKey="Dickey A" first="Alexia" last="Dickey">Alexia Dickey</name><affiliation><nlm:affiliation>Department of Natural Sciences Northeastern State University at Broken Arrow, Broken Arrow, OK 74014, USA. dickey@nsuok.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Kevin Yueju" sort="Wang, Kevin Yueju" uniqKey="Wang K" first="Kevin Yueju" last="Wang">Kevin Yueju Wang</name><affiliation><nlm:affiliation>Department of Natural Sciences Northeastern State University at Broken Arrow, Broken Arrow, OK 74014, USA. wang03@nsuok.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Batch Cell Culture Techniques</term><term>Bioreactors</term><term>Biotechnology</term><term>Genetic Engineering</term><term>Glycosylation</term><term>Humans</term><term>Medicine, Traditional (methods)</term><term>Plant Cells</term><term>Plant Preparations (chemistry)</term><term>Plant Preparations (isolation & purification)</term><term>Plant Preparations (pharmacology)</term><term>Plant Preparations (therapeutic use)</term><term>Plants, Genetically Modified</term><term>Plants, Medicinal (chemistry)</term><term>Plants, Medicinal (genetics)</term><term>Plants, Medicinal (metabolism)</term><term>Polysaccharides (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Preparations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Plant Preparations</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants, Medicinal</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plants, Medicinal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plants, Medicinal</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Medicine, Traditional</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Preparations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Preparations</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Batch Cell Culture Techniques</term><term>Bioreactors</term><term>Biotechnology</term><term>Genetic Engineering</term><term>Glycosylation</term><term>Humans</term><term>Plant Cells</term><term>Plants, Genetically Modified</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plant molecular farming (PMF), defined as the practice of using plants to produce human therapeutic proteins, has received worldwide interest. PMF has grown and advanced considerably over the past two decades. A number of therapeutic proteins have been produced in plants, some of which have been through pre-clinical or clinical trials and are close to commercialization. Plants have the potential to mass-produce pharmaceutical products with less cost than traditional methods. Tobacco-derived antibodies have been tested and used to combat the Ebola outbreak in Africa. Genetically engineered immunoadhesin (DPP4-Fc) produced in green plants has been shown to be able to bind to MERS-CoV (Middle East Respiratory Syndrome), preventing the virus from infecting lung cells. Biosafety concerns (such as pollen contamination and immunogenicity of plant-specific glycans) and costly downstream extraction and purification requirements, however, have hampered PMF production from moving from the laboratory to industrial application. In this review, the challenges and opportunities of PMF are discussed. Topics addressed include; transformation and expression systems, plant bioreactors, safety concerns, and various opportunities to produce topical applications and health supplements.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26633378</PMID><DateCompleted><Year>2016</Year><Month>09</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month><Day>02</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Plants as Factories for Human Pharmaceuticals: Applications and Challenges.</ArticleTitle><Pagination><MedlinePgn>28549-65</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms161226122</ELocationID><Abstract><AbstractText>Plant molecular farming (PMF), defined as the practice of using plants to produce human therapeutic proteins, has received worldwide interest. PMF has grown and advanced considerably over the past two decades. A number of therapeutic proteins have been produced in plants, some of which have been through pre-clinical or clinical trials and are close to commercialization. Plants have the potential to mass-produce pharmaceutical products with less cost than traditional methods. Tobacco-derived antibodies have been tested and used to combat the Ebola outbreak in Africa. Genetically engineered immunoadhesin (DPP4-Fc) produced in green plants has been shown to be able to bind to MERS-CoV (Middle East Respiratory Syndrome), preventing the virus from infecting lung cells. Biosafety concerns (such as pollen contamination and immunogenicity of plant-specific glycans) and costly downstream extraction and purification requirements, however, have hampered PMF production from moving from the laboratory to industrial application. In this review, the challenges and opportunities of PMF are discussed. Topics addressed include; transformation and expression systems, plant bioreactors, safety concerns, and various opportunities to produce topical applications and health supplements.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. yaojian2002@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weng</LastName><ForeName>Yunqi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. wengyunqi@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dickey</LastName><ForeName>Alexia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Natural Sciences Northeastern State University at Broken Arrow, Broken Arrow, OK 74014, USA. dickey@nsuok.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Kevin Yueju</ForeName><Initials>KY</Initials><AffiliationInfo><Affiliation>Department of Natural Sciences Northeastern State University at Broken Arrow, Broken Arrow, OK 74014, USA. wang03@nsuok.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P20 GM103447</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 RR016478</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>8P20GM103447</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., 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MajorTopicYN="N">Biotechnology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005818" MajorTopicYN="N">Genetic Engineering</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008519" MajorTopicYN="N">Medicine, Traditional</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059828" MajorTopicYN="N">Plant Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D028321" MajorTopicYN="Y">Plant Preparations</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" 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