Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein.
Identifieur interne : 001332 ( PubMed/Corpus ); précédent : 001331; suivant : 001333Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein.
Auteurs : Chung-Ke Chang ; Shou-Chen Lo ; Yong-Sheng Wang ; Ming-Hon HouSource :
- Drug discovery today [ 1878-5832 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Nucleocapsid Proteins.
- chemical , metabolism : Nucleocapsid Proteins.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections.
- metabolism : Coronavirus Infections.
- Animals, Humans.
Abstract
The advent of severe acute respiratory syndrome (SARS) in the 21st century and the recent outbreak of Middle-East respiratory syndrome (MERS) highlight the importance of coronaviruses (CoVs) as human pathogens, emphasizing the need for development of novel antiviral strategies to combat acute respiratory infections caused by CoVs. Recent studies suggest that nucleocapsid (N) proteins from coronaviruses and other viruses can be useful antiviral drug targets against viral infections. This review aims to provide readers with a concise survey of the structural features of coronavirus N proteins and how these features provide insights into structure-based development of therapeutics against coronaviruses. We will also present our latest results on MERS-CoV N protein and its potential as an antiviral drug target.
DOI: 10.1016/j.drudis.2015.11.015
PubMed: 26691874
Links to Exploration step
pubmed:26691874Le document en format XML
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Electronic address: mhho@dragon.nchu.edu.tw.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26691874</idno><idno type="pmid">26691874</idno><idno type="doi">10.1016/j.drudis.2015.11.015</idno><idno type="wicri:Area/PubMed/Corpus">001332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein.</title><author><name sortKey="Chang, Chung Ke" sort="Chang, Chung Ke" uniqKey="Chang C" first="Chung-Ke" last="Chang">Chung-Ke Chang</name><affiliation><nlm:affiliation>Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><affiliation><nlm:affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name><affiliation><nlm:affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><affiliation><nlm:affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan. 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Recent studies suggest that nucleocapsid (N) proteins from coronaviruses and other viruses can be useful antiviral drug targets against viral infections. This review aims to provide readers with a concise survey of the structural features of coronavirus N proteins and how these features provide insights into structure-based development of therapeutics against coronaviruses. We will also present our latest results on MERS-CoV N protein and its potential as an antiviral drug target. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26691874</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5832</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Drug discovery today</Title><ISOAbbreviation>Drug Discov. 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This review aims to provide readers with a concise survey of the structural features of coronavirus N proteins and how these features provide insights into structure-based development of therapeutics against coronaviruses. We will also present our latest results on MERS-CoV N protein and its potential as an antiviral drug target. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Chung-ke</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lo</LastName><ForeName>Shou-Chen</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yong-Sheng</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Ming-Hon</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan. 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IdType="doi">10.1016/j.drudis.2015.11.015</ArticleId><ArticleId IdType="pmc">PMC7108309</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1049-53</Citation><ArticleIdList><ArticleId IdType="pubmed">24856660</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol Methods. 2007 Feb;139(2):175-80</Citation><ArticleIdList><ArticleId IdType="pubmed">17079026</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Infect Dis. 2007 Nov 1;196(9):1321-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17922396</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2005 Sep;79(17):11476-86</Citation><ArticleIdList><ArticleId IdType="pubmed">16103198</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2007 Jan;81(2):548-57</Citation><ArticleIdList><ArticleId IdType="pubmed">17108024</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEBS Lett. 2013 Jan 16;587(2):120-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23178926</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 1997 Oct;71(10):7393-403</Citation><ArticleIdList><ArticleId IdType="pubmed">9311818</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proteomics. 2005 Mar;5(4):925-37</Citation><ArticleIdList><ArticleId IdType="pubmed">15759315</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2003 Dec;1(3):209-18</Citation><ArticleIdList><ArticleId IdType="pubmed">15035025</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vaccine. 2008 Mar 20;26(13):1644-51</Citation><ArticleIdList><ArticleId IdType="pubmed">18289745</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEBS J. 2014 Sep;281(18):4085-96</Citation><ArticleIdList><ArticleId IdType="pubmed">25039866</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS One. 2012;7(6):e38638</Citation><ArticleIdList><ArticleId IdType="pubmed">22719912</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Jul;20(7):1231-4</Citation><ArticleIdList><ArticleId IdType="pubmed">24964193</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Influenza Other Respir Viruses. 2013 Nov;7(6):1040-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23462106</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Gen Virol. 2012 Jun;93(Pt 6):1236-1246</Citation><ArticleIdList><ArticleId IdType="pubmed">22422061</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Opin Virol. 2014 Oct;8:45-53</Citation><ArticleIdList><ArticleId IdType="pubmed">24997250</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):582-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19124777</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2007 May 15;104(20):8311-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17494761</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2009 Feb 20;284(8):5229-39</Citation><ArticleIdList><ArticleId IdType="pubmed">19106108</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antivir Chem Chemother. 2012 Jul 26;23(3):77-91</Citation><ArticleIdList><ArticleId IdType="pubmed">22837443</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2006 Jun 23;281(25):17134-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16627473</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Top Med Chem. 2004;4(15):1605-22</Citation><ArticleIdList><ArticleId IdType="pubmed">15579099</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16515-20</Citation><ArticleIdList><ArticleId IdType="pubmed">21930946</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vaccine. 2008 Dec 2;26(51):6678-84</Citation><ArticleIdList><ArticleId IdType="pubmed">18805454</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mol Immunol. 2008 Feb;45(4):868-75</Citation><ArticleIdList><ArticleId IdType="pubmed">17905435</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2005 Jun;79(11):6620-30</Citation><ArticleIdList><ArticleId IdType="pubmed">15890900</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 1987 Jun;61(6):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">3033313</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Microbiol. 2006 Jun;44(6):2063-71</Citation><ArticleIdList><ArticleId IdType="pubmed">16757599</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Microbiol. 2013 Sep;51(9):3039-46</Citation><ArticleIdList><ArticleId IdType="pubmed">23850954</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Bioinformatics. 2011 Aug 1;27(15):2083-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21636590</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nucleic Acids Res. 2006;34(17):4816-25</Citation><ArticleIdList><ArticleId IdType="pubmed">16971454</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Jpn J Infect Dis. 2015;68(2):138-41</Citation><ArticleIdList><ArticleId IdType="pubmed">25420656</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2006 Apr 21;281(16):10669-81</Citation><ArticleIdList><ArticleId IdType="pubmed">16431923</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2011 Dec;85(23):12201-15</Citation><ArticleIdList><ArticleId IdType="pubmed">21937658</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Microbiol. 2010 Aug;48(8):2940-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20554810</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2009 Mar;83(5):2255-64</Citation><ArticleIdList><ArticleId IdType="pubmed">19052082</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS One. 2013 May 23;8(5):e65045</Citation><ArticleIdList><ArticleId IdType="pubmed">23717688</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS Med. 2005 Aug;2(8):e240</Citation><ArticleIdList><ArticleId IdType="pubmed">16104827</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2013 May;57(5):2231-42</Citation><ArticleIdList><ArticleId IdType="pubmed">23459490</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Protein Sci. 2009 Nov;18(11):2209-18</Citation><ArticleIdList><ArticleId IdType="pubmed">19691129</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2005 Jan 5;331(1):128-35</Citation><ArticleIdList><ArticleId IdType="pubmed">15582659</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Adv Exp Med Biol. 1990;276:239-46</Citation><ArticleIdList><ArticleId IdType="pubmed">1966408</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Natl Health Stat Report. 2008 Aug 6;(3):1-39</Citation><ArticleIdList><ArticleId IdType="pubmed">18972720</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2004 Nov;78(22):12683-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15507657</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biomol Struct Dyn. 2015 Sep;33(9):1899-912</Citation><ArticleIdList><ArticleId IdType="pubmed">25333630</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biochemistry. 2006 Oct 3;45(39):11827-35</Citation><ArticleIdList><ArticleId IdType="pubmed">17002283</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pediatr Infect Dis J. 2012 Mar;31(3):235-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22094637</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2014 Mar;103:39-50</Citation><ArticleIdList><ArticleId IdType="pubmed">24418573</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Jpn J Infect Dis. 2012;65(3):270-2</Citation><ArticleIdList><ArticleId IdType="pubmed">22627314</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2004 May;78(9):4638-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15078946</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Genet. 2005 Jul;37(7):701-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15965477</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Anal Chem. 2012 Aug 7;84(15):6391-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22712523</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2006 Jul;80(13):6612-20</Citation><ArticleIdList><ArticleId IdType="pubmed">16775348</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Immunol Lett. 2004 Apr 15;92(3):237-43</Citation><ArticleIdList><ArticleId IdType="pubmed">15081618</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vet Rec. 1979 Feb 24;104(8):168-9</Citation><ArticleIdList><ArticleId IdType="pubmed">111407</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2013 Dec;11(12):836-48</Citation><ArticleIdList><ArticleId IdType="pubmed">24217413</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Future Microbiol. 2013 Dec;8(12):1537-45</Citation><ArticleIdList><ArticleId IdType="pubmed">24266354</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Mol Biol. 2007 May 11;368(4):1075-86</Citation><ArticleIdList><ArticleId IdType="pubmed">17379242</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS Med. 2006 Dec;3(12):e525</Citation><ArticleIdList><ArticleId IdType="pubmed">17194199</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):977-80</Citation><ArticleIdList><ArticleId IdType="pubmed">26249685</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2006 Aug;80(16):7918-28</Citation><ArticleIdList><ArticleId IdType="pubmed">16873249</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vaccine. 2007 Aug 10;25(32):6070-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17629360</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2007 Jun;81(11):6079-88</Citation><ArticleIdList><ArticleId IdType="pubmed">17392374</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mol Biosyst. 2012 Jan;8(1):97-104</Citation><ArticleIdList><ArticleId IdType="pubmed">21874205</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Mol Biol. 2008 Jul 18;380(4):608-22</Citation><ArticleIdList><ArticleId IdType="pubmed">18561946</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2013 Oct;100(1):286-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24012996</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biochim Biophys Acta. 2013 Jun;1834(6):1054-62</Citation><ArticleIdList><ArticleId IdType="pubmed">23501675</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16169905</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Adv Exp Med Biol. 1990;276:235-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1715663</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>BMC Infect Dis. 2012 Dec 20;12:365</Citation><ArticleIdList><ArticleId IdType="pubmed">23256846</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2007 May 15;104(20):8316-21</Citation><ArticleIdList><ArticleId IdType="pubmed">17488811</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2013 Aug 20;4(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">23963179</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pediatr Infect Dis J. 2009 Aug;28(8):682-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19633513</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Virol. 2012 Feb;53(2):135-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22188723</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2003 Oct 25;315(2):269-74</Citation><ArticleIdList><ArticleId IdType="pubmed">14585329</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Drug Discov. 2005 Oct;4(10):845-53</Citation><ArticleIdList><ArticleId IdType="pubmed">16184083</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Int J Nanomedicine. 2012;7:2173-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22619553</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antivir Ther. 2007;12(4 Pt B):651-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17944272</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Chem. 2014 Mar 27;57(6):2247-57</Citation><ArticleIdList><ArticleId IdType="pubmed">24564608</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEBS J. 2008 Aug;275(16):4152-63</Citation><ArticleIdList><ArticleId IdType="pubmed">18631359</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15366-71</Citation><ArticleIdList><ArticleId IdType="pubmed">21896751</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Protein Cell. 2010 Jul;1(7):688-97</Citation><ArticleIdList><ArticleId IdType="pubmed">21203940</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mol Biosyst. 2016 Jan;12(1):59-66</Citation><ArticleIdList><ArticleId IdType="pubmed">26542199</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Microbiol Biotechnol. 2013 Feb;23(2):267-73</Citation><ArticleIdList><ArticleId IdType="pubmed">23412071</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Clin Diagn Lab Immunol. 2005 Nov;12(11):1317-21</Citation><ArticleIdList><ArticleId IdType="pubmed">16275947</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biochem Pharmacol. 2012 Nov 15;84(10):1351-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22935448</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2010 Feb;84(4):2169-75</Citation><ArticleIdList><ArticleId IdType="pubmed">19955314</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Gen Virol. 1981 Mar;53(Pt 1):67-74</Citation><ArticleIdList><ArticleId IdType="pubmed">6268741</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2015 Sep 5;386(9997):995-1007</Citation><ArticleIdList><ArticleId IdType="pubmed">26049252</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Mol Biol. 2009 Dec 4;394(3):544-57</Citation><ArticleIdList><ArticleId IdType="pubmed">19782089</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2007 Apr;81(7):3051-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17079323</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Natl Health Stat Report. 2010 Nov 3;(27):1-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21089986</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Gen Virol. 1978 Jun;39(3):497-504</Citation><ArticleIdList><ArticleId IdType="pubmed">660165</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vaccine. 2008 Apr 16;26(17):2164-74</Citation><ArticleIdList><ArticleId IdType="pubmed">18346823</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2004 Aug;78(16):8824-34</Citation><ArticleIdList><ArticleId IdType="pubmed">15280490</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2005 Nov;79(22):13848-55</Citation><ArticleIdList><ArticleId IdType="pubmed">16254320</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biomed Sci. 2006 Jan;13(1):59-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16228284</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Virol. 2008 Apr;80(4):716-23</Citation><ArticleIdList><ArticleId IdType="pubmed">18297694</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Nov;14(11):1090-1095</Citation><ArticleIdList><ArticleId IdType="pubmed">25278221</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Vaccine. 2006 Apr 12;24(16):3100-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16494977</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Expert Opin Drug Discov. 2015 Apr;10(4):345-71</Citation><ArticleIdList><ArticleId IdType="pubmed">25792362</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Gene Ther. 2009 Nov;16(11):1353-62</Citation><ArticleIdList><ArticleId IdType="pubmed">19727132</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2014 Apr;88(8):4451-65</Citation><ArticleIdList><ArticleId 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