Development of Small-Molecule MERS-CoV Inhibitors.
Identifieur interne : 000702 ( PubMed/Corpus ); précédent : 000701; suivant : 000703Development of Small-Molecule MERS-CoV Inhibitors.
Auteurs : Ruiying Liang ; Lili Wang ; Naru Zhang ; Xiaoqian Deng ; Meng Su ; Yudan Su ; Lanfang Hu ; Chen He ; Tianlei Ying ; Shibo Jiang ; Fei YuSource :
- Viruses [ 1999-4915 ] ; 2018.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Drug Discovery, Humans, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics (prevention & control), Small Molecule Libraries (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- drug therapy : Coronavirus Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Pandemics.
- Animals, Drug Discovery, Humans, Mice.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.
DOI: 10.3390/v10120721
PubMed: 30562987
Links to Exploration step
pubmed:30562987Le document en format XML
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.</div>
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