Development of Small-Molecule MERS-CoV Inhibitors.
Identifieur interne : 000702 ( PubMed/Corpus ); précédent : 000701; suivant : 000703Development of Small-Molecule MERS-CoV Inhibitors.
Auteurs : Ruiying Liang ; Lili Wang ; Naru Zhang ; Xiaoqian Deng ; Meng Su ; Yudan Su ; Lanfang Hu ; Chen He ; Tianlei Ying ; Shibo Jiang ; Fei YuSource :
- Viruses [ 1999-4915 ] ; 2018.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Drug Discovery, Humans, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics (prevention & control), Small Molecule Libraries (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- drug therapy : Coronavirus Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Pandemics.
- Animals, Drug Discovery, Humans, Mice.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.
DOI: 10.3390/v10120721
PubMed: 30562987
Links to Exploration step
pubmed:30562987Le document en format XML
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Ruiying" sort="Liang, Ruiying" uniqKey="Liang R" first="Ruiying" last="Liang">Ruiying Liang</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. ruiyingliang@outlook.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><affiliation><nlm:affiliation>Research Center of Chinese Jujube, Hebei Agricultural University, Baoding 071001, China. yywll@hebau.edu.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name><affiliation><nlm:affiliation>Department of Clinical Medicine, Faculty of Medicine, Zhejiang University City College, Hangzhou 310015, China. zhangnr@zucc.edu.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Xiaoqian" sort="Deng, Xiaoqian" uniqKey="Deng X" first="Xiaoqian" last="Deng">Xiaoqian Deng</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. dengxiaoqian0926@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Meng" sort="Su, Meng" uniqKey="Su M" first="Meng" last="Su">Meng Su</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. sumeng123@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Yudan" sort="Su, Yudan" uniqKey="Su Y" first="Yudan" last="Su">Yudan Su</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. suyudan123@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Lanfang" sort="Hu, Lanfang" uniqKey="Hu L" first="Lanfang" last="Hu">Lanfang Hu</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. hlf0519@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="He, Chen" sort="He, Chen" uniqKey="He C" first="Chen" last="He">Chen He</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. hechen285@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation><nlm:affiliation>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. shmyf@hebau.edu.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:affiliation>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. shibojiang@fudan.edu.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><affiliation><nlm:affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. tlying@fudan.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Discovery</term><term>Humans</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Pandemics (prevention & control)</term><term>Small Molecule Libraries (pharmacology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Discovery</term><term>Humans</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30562987</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>12</Issue><PubDate><Year>2018</Year><Month>12</Month><Day>17</Day></PubDate></JournalIssue><Title>Viruses</Title><ISOAbbreviation>Viruses</ISOAbbreviation></Journal><ArticleTitle>Development of Small-Molecule MERS-CoV Inhibitors.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E721</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/v10120721</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Ruiying</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. ruiyingliang@outlook.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lili</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Research Center of Chinese Jujube, Hebei Agricultural University, Baoding 071001, China. yywll@hebau.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Naru</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Clinical Medicine, Faculty of Medicine, Zhejiang University City College, Hangzhou 310015, China. zhangnr@zucc.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Xiaoqian</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. dengxiaoqian0926@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. sumeng123@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Yudan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. suyudan123@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Lanfang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. hlf0519@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Chen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. hechen285@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ying</LastName><ForeName>Tianlei</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. shmyf@hebau.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Shibo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. shibojiang@fudan.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Fei</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0001-6332-4326</Identifier><AffiliationInfo><Affiliation>College of Life and Science, Hebei Agricultural University, Baoding 071001, China. tlying@fudan.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Viruses</MedlineTA><NlmUniqueID>101509722</NlmUniqueID><ISSNLinking>1999-4915</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054852">Small Molecule Libraries</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" 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