Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.
Identifieur interne : 000642 ( PubMed/Corpus ); précédent : 000641; suivant : 000643Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.
Auteurs : Jun Yong Choi ; Jin Ok Oh ; Jin Young Ahn ; Heun Choi ; Jung Ho Kim ; Hye Seong ; Su Jin Jeong ; Nam Su Ku ; Joon-Sup Yeom ; Jae-Phil ChoiSource :
- Clinical and experimental vaccine research [ 2287-3651 ] ; 2019.
Abstract
We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
DOI: 10.7774/cevr.2019.8.1.86
PubMed: 30775355
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Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Heun" sort="Choi, Heun" uniqKey="Choi H" first="Heun" last="Choi">Heun Choi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jung Ho" sort="Kim, Jung Ho" uniqKey="Kim J" first="Jung Ho" last="Kim">Jung Ho Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Seong, Hye" sort="Seong, Hye" uniqKey="Seong H" first="Hye" last="Seong">Hye Seong</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Yeom, Joon Sup" sort="Yeom, Joon Sup" uniqKey="Yeom J" first="Joon-Sup" last="Yeom">Joon-Sup Yeom</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, 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last="Oh">Jin Ok Oh</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Jin Young" sort="Ahn, Jin Young" uniqKey="Ahn J" first="Jin Young" last="Ahn">Jin Young Ahn</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Heun" sort="Choi, Heun" uniqKey="Choi H" first="Heun" last="Choi">Heun Choi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jung Ho" sort="Kim, Jung Ho" uniqKey="Kim J" first="Jung Ho" last="Kim">Jung Ho Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Seong, Hye" sort="Seong, Hye" uniqKey="Seong H" first="Hye" last="Seong">Hye Seong</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Yeom, Joon Sup" sort="Yeom, Joon Sup" uniqKey="Yeom J" first="Joon-Sup" last="Yeom">Joon-Sup Yeom</name><affiliation><nlm:affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical and experimental vaccine research</title><idno type="ISSN">2287-3651</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30775355</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2287-3651</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Clinical and experimental vaccine research</Title><ISOAbbreviation>Clin Exp Vaccine Res</ISOAbbreviation></Journal><ArticleTitle>Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.</ArticleTitle><Pagination><MedlinePgn>86-88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7774/cevr.2019.8.1.86</ELocationID><Abstract><AbstractText>We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Jun Yong</ForeName><Initials>JY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2775-3315</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Jin Ok</ForeName><Initials>JO</Initials><Identifier Source="ORCID">0000-0002-2086-1751</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Jin Young</ForeName><Initials>JY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3740-2826</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Heun</ForeName><Initials>H</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9622-9381</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jung Ho</ForeName><Initials>JH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5033-3482</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seong</LastName><ForeName>Hye</ForeName><Initials>H</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5633-7214</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Su Jin</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4025-4542</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ku</LastName><ForeName>Nam Su</ForeName><Initials>NS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9717-4327</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeom</LastName><ForeName>Joon-Sup</ForeName><Initials>JS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8940-7170</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Jae-Phil</ForeName><Initials>JP</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4805-7930</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>Clin Exp Vaccine Res</MedlineTA><NlmUniqueID>101592344</NlmUniqueID><ISSNLinking>2287-3651</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Middle East respiratory syndrome coronavirus</Keyword><Keyword MajorTopicYN="N">Neutralizing antibodies</Keyword><Keyword MajorTopicYN="N">Serum</Keyword></KeywordList><CoiStatement>No potential conflict of interest relevant to this article was reported.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>06</Day></PubMedPubDate><PubMedPubDate 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