MersV1, PubMed, Corpus, bibRecord, 000197

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.

Identifieur interne : 000197 ( PubMed/Corpus ); précédent : 000196; suivant : 000198

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.

Auteurs : Abdo A. Elfiky

Source :

Life sciences [ 1879-0631 ] ; 2020.

RBID : pubmed:32119961

English descriptors

KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (chemistry), Adenosine Monophosphate (metabolism), Alanine (analogs & derivatives), Alanine (chemistry), Alanine (metabolism), Alphacoronavirus (enzymology), Alphacoronavirus (genetics), Amino Acid Sequence, Antiviral Agents (chemistry), Antiviral Agents (metabolism), Betacoronavirus (enzymology), Betacoronavirus (genetics), Catalytic Domain, Computational Biology (methods), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Repositioning (methods), Guanosine Monophosphate (analogs & derivatives), Guanosine Monophosphate (chemistry), Guanosine Monophosphate (metabolism), Guanosine Triphosphate (chemistry), Guanosine Triphosphate (metabolism), Humans, Molecular Docking Simulation, Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, RNA Replicase (antagonists & inhibitors), RNA Replicase (chemistry), RNA Replicase (metabolism), Ribavirin (chemistry), Ribavirin (metabolism), Sequence Alignment, Sequence Homology, Amino Acid, Sofosbuvir (chemistry), Sofosbuvir (metabolism), Thermodynamics, Uridine Triphosphate (chemistry), Uridine Triphosphate (metabolism), Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Viral Proteins (metabolism).
MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine, Guanosine Monophosphate.
- chemical , antagonists & inhibitors : RNA Replicase, Viral Proteins.
- chemical , chemistry : Adenosine Monophosphate, Alanine, Antiviral Agents, Guanosine Monophosphate, Guanosine Triphosphate, RNA Replicase, Ribavirin, Sofosbuvir, Uridine Triphosphate, Viral Proteins.
- chemical , metabolism : Adenosine Monophosphate, Alanine, Antiviral Agents, Guanosine Monophosphate, Guanosine Triphosphate, RNA Replicase, Ribavirin, Sofosbuvir, Uridine Triphosphate, Viral Proteins.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- enzymology : Alphacoronavirus, Betacoronavirus.
- genetics : Alphacoronavirus, Betacoronavirus.
- methods : Computational Biology, Drug Repositioning.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Amino Acid Sequence, Catalytic Domain, Humans, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Sequence Alignment, Sequence Homology, Amino Acid, Thermodynamics.

Abstract

A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).

DOI: 10.1016/j.lfs.2020.117477
PubMed: 32119961

Links to Exploration step

pubmed:32119961

Le document en format XML

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<term>Adenosine Monophosphate (chemistry)</term>
<term>Adenosine Monophosphate (metabolism)</term>
<term>Alanine (analogs & derivatives)</term>
<term>Alanine (chemistry)</term>
<term>Alanine (metabolism)</term>
<term>Alphacoronavirus (enzymology)</term>
<term>Alphacoronavirus (genetics)</term>
<term>Amino Acid Sequence</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (metabolism)</term>
<term>Betacoronavirus (enzymology)</term>
<term>Betacoronavirus (genetics)</term>
<term>Catalytic Domain</term>
<term>Computational Biology (methods)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Drug Repositioning (methods)</term>
<term>Guanosine Monophosphate (analogs & derivatives)</term>
<term>Guanosine Monophosphate (chemistry)</term>
<term>Guanosine Monophosphate (metabolism)</term>
<term>Guanosine Triphosphate (chemistry)</term>
<term>Guanosine Triphosphate (metabolism)</term>
<term>Humans</term>
<term>Molecular Docking Simulation</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Protein Binding</term>
<term>Protein Conformation, alpha-Helical</term>
<term>Protein Conformation, beta-Strand</term>
<term>Protein Interaction Domains and Motifs</term>
<term>RNA Replicase (antagonists & inhibitors)</term>
<term>RNA Replicase (chemistry)</term>
<term>RNA Replicase (metabolism)</term>
<term>Ribavirin (chemistry)</term>
<term>Ribavirin (metabolism)</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sofosbuvir (chemistry)</term>
<term>Sofosbuvir (metabolism)</term>
<term>Thermodynamics</term>
<term>Uridine Triphosphate (chemistry)</term>
<term>Uridine Triphosphate (metabolism)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Guanosine Monophosphate</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Antiviral Agents</term>
<term>Guanosine Monophosphate</term>
<term>Guanosine Triphosphate</term>
<term>RNA Replicase</term>
<term>Ribavirin</term>
<term>Sofosbuvir</term>
<term>Uridine Triphosphate</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Antiviral Agents</term>
<term>Guanosine Monophosphate</term>
<term>Guanosine Triphosphate</term>
<term>RNA Replicase</term>
<term>Ribavirin</term>
<term>Sofosbuvir</term>
<term>Uridine Triphosphate</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Alphacoronavirus</term>
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alphacoronavirus</term>
<term>Betacoronavirus</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term>
<term>Drug Repositioning</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Catalytic Domain</term>
<term>Humans</term>
<term>Molecular Docking Simulation</term>
<term>Protein Binding</term>
<term>Protein Conformation, alpha-Helical</term>
<term>Protein Conformation, beta-Strand</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Thermodynamics</term>
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<front><div type="abstract" xml:lang="en">A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32119961</PMID>
<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0631</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>248</Volume>
<PubDate><Year>2020</Year>
<Month>May</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Life sciences</Title>
<ISOAbbreviation>Life Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>117477</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0024-3205(20)30225-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.lfs.2020.117477</ELocationID>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin.</AbstractText>
<AbstractText Label="KEY FINDINGS" NlmCategory="RESULTS">The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease.</AbstractText>
<AbstractText Label="SIGNIFICANCE" NlmCategory="CONCLUSIONS">The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Elfiky</LastName>
<ForeName>Abdo A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; College of Applied Medical Sciences, University of Al-Jouf, Saudi Arabia. Electronic address: abdo@sci.cu.edu.eg.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>02</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Life Sci</MedlineTA>
<NlmUniqueID>0375521</NlmUniqueID>
<ISSNLinking>0024-3205</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C557801">IDX184</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>3QKI37EEHE</RegistryNumber>
<NameOfSubstance UI="C000606551">remdesivir</NameOfSubstance>
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<Chemical><RegistryNumber>415SHH325A</RegistryNumber>
<NameOfSubstance UI="D000249">Adenosine Monophosphate</NameOfSubstance>
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<Chemical><RegistryNumber>49717AWG6K</RegistryNumber>
<NameOfSubstance UI="D012254">Ribavirin</NameOfSubstance>
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<Chemical><RegistryNumber>85-32-5</RegistryNumber>
<NameOfSubstance UI="D006157">Guanosine Monophosphate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>86-01-1</RegistryNumber>
<NameOfSubstance UI="D006160">Guanosine Triphosphate</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber>
<NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>OF5P57N2ZX</RegistryNumber>
<NameOfSubstance UI="D000409">Alanine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>UT0S826Z60</RegistryNumber>
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<Chemical><RegistryNumber>WJ6CA3ZU8B</RegistryNumber>
<NameOfSubstance UI="D000069474">Sofosbuvir</NameOfSubstance>
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</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
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<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
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<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058492" MajorTopicYN="N">Drug Repositioning</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006157" MajorTopicYN="N">Guanosine Monophosphate</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006160" MajorTopicYN="N">Guanosine Triphosphate</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072756" MajorTopicYN="N">Protein Conformation, alpha-Helical</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072757" MajorTopicYN="N">Protein Conformation, beta-Strand</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012324" MajorTopicYN="N">RNA Replicase</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069474" MajorTopicYN="N">Sofosbuvir</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013816" MajorTopicYN="N">Thermodynamics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014544" MajorTopicYN="N">Uridine Triphosphate</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Docking</Keyword>
<Keyword MajorTopicYN="N">Nucleotide inhibitors</Keyword>
<Keyword MajorTopicYN="N">RdRp</Keyword>
<Keyword MajorTopicYN="N">Sofosbuvir</Keyword>
<Keyword MajorTopicYN="N">Structural bioinformatics</Keyword>
<Keyword MajorTopicYN="N">Wuhan coronavirus</Keyword>
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<CoiStatement>Declaration of competing interest The author declares that there is no competing interest in this work.</CoiStatement>
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Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.

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