Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.
Identifieur interne : 001B95 ( PubMed/Checkpoint ); précédent : 001B94; suivant : 001B96Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.
Auteurs : Jasper F W. Chan [République populaire de Chine] ; Kwok-Hung Chan ; Richard Y T. Kao ; Kelvin K W. To ; Bo-Jian Zheng ; Clara P Y. Li ; Patrick T W. Li ; Jun Dai ; Florence K Y. Mok ; Honglin Chen ; Frederick G. Hayden ; Kwok-Yung YuenSource :
- The Journal of infection [ 1532-2742 ] ; 2013.
Descripteurs français
- KwdFr :
- Acide mycophénolique (pharmacologie), Animaux, Antiviraux (pharmacologie), Cellules Vero, Charge virale (), Coronavirus (), Découverte de médicament (), Flambées de maladies, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Interférons (pharmacologie), Maladies transmissibles émergentes (traitement médicamenteux), Maladies transmissibles émergentes (virologie), Méthode des plages virales, Ribavirine (pharmacologie), Tests de criblage à haut débit ().
- MESH :
- pharmacologie : Acide mycophénolique, Antiviraux, Interférons, Ribavirine.
- traitement médicamenteux : Infections à coronavirus, Maladies transmissibles émergentes.
- virologie : Infections à coronavirus, Maladies transmissibles émergentes.
- Animaux, Cellules Vero, Charge virale, Coronavirus, Découverte de médicament, Flambées de maladies, Humains, Méthode des plages virales, Tests de criblage à haut débit.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Chlorocebus aethiops, Communicable Diseases, Emerging (drug therapy), Communicable Diseases, Emerging (virology), Coronavirus (drug effects), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Disease Outbreaks, Drug Discovery (methods), High-Throughput Screening Assays (methods), Humans, Interferons (pharmacology), Mycophenolic Acid (pharmacology), Ribavirin (pharmacology), Vero Cells, Viral Load (drug effects), Viral Plaque Assay.
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferons, Mycophenolic Acid, Ribavirin.
- drug effects : Coronavirus, Viral Load.
- drug therapy : Communicable Diseases, Emerging, Coronavirus Infections.
- methods : Drug Discovery, High-Throughput Screening Assays.
- virology : Communicable Diseases, Emerging, Coronavirus Infections.
- Animals, Chlorocebus aethiops, Disease Outbreaks, Humans, Vero Cells, Viral Plaque Assay.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.
DOI: 10.1016/j.jinf.2013.09.029
PubMed: 24096239
Affiliations:
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pubmed:24096239Le document en format XML
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<term>Charge virale ()</term>
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<term>Interférons</term>
<term>Ribavirine</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
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<term>Vero Cells</term>
<term>Viral Plaque Assay</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24096239</PMID>
<DateCompleted><Year>2014</Year>
<Month>07</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>67</Volume>
<Issue>6</Issue>
<PubDate><Year>2013</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of infection</Title>
<ISOAbbreviation>J. Infect.</ISOAbbreviation>
</Journal>
<ArticleTitle>Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>606-16</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2013.09.029</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0163-4453(13)00298-3</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used small compound-based forward chemical genetics to screen a chemical library of 1280 known drugs against influenza A virus in Biosafety Level-2 laboratory. We then assessed the anti-MERS-CoV activities of the identified compounds and of interferons, nelfinavir, and lopinavir because of their reported anti-coronavirus activities in terms of cytopathic effect inhibition, viral yield reduction, and plaque reduction assays in Biosafety Level-3 laboratory.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Ten compounds were identified as primary hits in high-throughput screening. Only mycophenolic acid exhibited low EC50 and high selectivity index. Additionally, ribavirin and interferons also exhibited in-vitro anti-MERS-CoV activity. The serum concentrations achievable at therapeutic doses of mycophenolic acid and interferon-β1b were 60-300 and 3-4 times higher than the concentrations at which in-vitro anti-MERS-CoV activities were demonstrated, whereas that of ribavirin was ∼2 times lower. Combination of mycophenolic acid and interferon-β1b lowered the EC50 of each drug by 1-3 times.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Interferon-β1b with mycophenolic acid should be considered in treatment trials of MERS.</AbstractText>
<CopyrightInformation>Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Jasper F W</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.</Affiliation>
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<ForeName>Kwok-Hung</ForeName>
<Initials>KH</Initials>
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<Author ValidYN="Y"><LastName>Kao</LastName>
<ForeName>Richard Y T</ForeName>
<Initials>RY</Initials>
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<Author ValidYN="Y"><LastName>To</LastName>
<ForeName>Kelvin K W</ForeName>
<Initials>KK</Initials>
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<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Bo-Jian</ForeName>
<Initials>BJ</Initials>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Clara P Y</ForeName>
<Initials>CP</Initials>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Patrick T W</ForeName>
<Initials>PT</Initials>
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<ForeName>Jun</ForeName>
<Initials>J</Initials>
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<Author ValidYN="Y"><LastName>Mok</LastName>
<ForeName>Florence K Y</ForeName>
<Initials>FK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Honglin</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hayden</LastName>
<ForeName>Frederick G</ForeName>
<Initials>FG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yuen</LastName>
<ForeName>Kwok-Yung</ForeName>
<Initials>KY</Initials>
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