Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.
Identifieur interne : 001B65 ( PubMed/Corpus ); précédent : 001B64; suivant : 001B66Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.
Auteurs : Jasper F W. Chan ; Kwok-Hung Chan ; Richard Y T. Kao ; Kelvin K W. To ; Bo-Jian Zheng ; Clara P Y. Li ; Patrick T W. Li ; Jun Dai ; Florence K Y. Mok ; Honglin Chen ; Frederick G. Hayden ; Kwok-Yung YuenSource :
- The Journal of infection [ 1532-2742 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Chlorocebus aethiops, Communicable Diseases, Emerging (drug therapy), Communicable Diseases, Emerging (virology), Coronavirus (drug effects), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Disease Outbreaks, Drug Discovery (methods), High-Throughput Screening Assays (methods), Humans, Interferons (pharmacology), Mycophenolic Acid (pharmacology), Ribavirin (pharmacology), Vero Cells, Viral Load (drug effects), Viral Plaque Assay.
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferons, Mycophenolic Acid, Ribavirin.
- drug effects : Coronavirus, Viral Load.
- drug therapy : Communicable Diseases, Emerging, Coronavirus Infections.
- methods : Drug Discovery, High-Throughput Screening Assays.
- virology : Communicable Diseases, Emerging, Coronavirus Infections.
- Animals, Chlorocebus aethiops, Disease Outbreaks, Humans, Vero Cells, Viral Plaque Assay.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.
DOI: 10.1016/j.jinf.2013.09.029
PubMed: 24096239
Links to Exploration step
pubmed:24096239Le document en format XML
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Kao</name></author><author><name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K W" last="To">Kelvin K W. To</name></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name></author><author><name sortKey="Li, Clara P Y" sort="Li, Clara P Y" uniqKey="Li C" first="Clara P Y" last="Li">Clara P Y. Li</name></author><author><name sortKey="Li, Patrick T W" sort="Li, Patrick T W" uniqKey="Li P" first="Patrick T W" last="Li">Patrick T W. Li</name></author><author><name sortKey="Dai, Jun" sort="Dai, Jun" uniqKey="Dai J" first="Jun" last="Dai">Jun Dai</name></author><author><name sortKey="Mok, Florence K Y" sort="Mok, Florence K Y" uniqKey="Mok F" first="Florence K Y" last="Mok">Florence K Y. Mok</name></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24096239</idno><idno type="pmid">24096239</idno><idno type="doi">10.1016/j.jinf.2013.09.029</idno><idno type="wicri:Area/PubMed/Corpus">001B65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.</title><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name></author><author><name sortKey="Kao, Richard Y T" sort="Kao, Richard Y T" uniqKey="Kao R" first="Richard Y T" last="Kao">Richard Y T. Kao</name></author><author><name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K W" last="To">Kelvin K W. To</name></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name></author><author><name sortKey="Li, Clara P Y" sort="Li, Clara P Y" uniqKey="Li C" first="Clara P Y" last="Li">Clara P Y. Li</name></author><author><name sortKey="Li, Patrick T W" sort="Li, Patrick T W" uniqKey="Li P" first="Patrick T W" last="Li">Patrick T W. Li</name></author><author><name sortKey="Dai, Jun" sort="Dai, Jun" uniqKey="Dai J" first="Jun" last="Dai">Jun Dai</name></author><author><name sortKey="Mok, Florence K Y" sort="Mok, Florence K Y" uniqKey="Mok F" first="Florence K Y" last="Mok">Florence K Y. Mok</name></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></analytic><series><title level="j">The Journal of infection</title><idno type="eISSN">1532-2742</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>Communicable Diseases, Emerging (drug therapy)</term><term>Communicable Diseases, Emerging (virology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Disease Outbreaks</term><term>Drug Discovery (methods)</term><term>High-Throughput Screening Assays (methods)</term><term>Humans</term><term>Interferons (pharmacology)</term><term>Mycophenolic Acid (pharmacology)</term><term>Ribavirin (pharmacology)</term><term>Vero Cells</term><term>Viral Load (drug effects)</term><term>Viral Plaque Assay</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term><term>Mycophenolic Acid</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term><term>High-Throughput Screening Assays</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Disease Outbreaks</term><term>Humans</term><term>Vero Cells</term><term>Viral Plaque Assay</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24096239</PMID><DateCompleted><Year>2014</Year><Month>07</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>6</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The Journal of infection</Title><ISOAbbreviation>J. Infect.</ISOAbbreviation></Journal><ArticleTitle>Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.</ArticleTitle><Pagination><MedlinePgn>606-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2013.09.029</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0163-4453(13)00298-3</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged to cause fatal infections in patients in the Middle East and traveler-associated secondary cases in Europe and Africa. Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used small compound-based forward chemical genetics to screen a chemical library of 1280 known drugs against influenza A virus in Biosafety Level-2 laboratory. We then assessed the anti-MERS-CoV activities of the identified compounds and of interferons, nelfinavir, and lopinavir because of their reported anti-coronavirus activities in terms of cytopathic effect inhibition, viral yield reduction, and plaque reduction assays in Biosafety Level-3 laboratory.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Ten compounds were identified as primary hits in high-throughput screening. Only mycophenolic acid exhibited low EC50 and high selectivity index. Additionally, ribavirin and interferons also exhibited in-vitro anti-MERS-CoV activity. The serum concentrations achievable at therapeutic doses of mycophenolic acid and interferon-β1b were 60-300 and 3-4 times higher than the concentrations at which in-vitro anti-MERS-CoV activities were demonstrated, whereas that of ribavirin was ∼2 times lower. Combination of mycophenolic acid and interferon-β1b lowered the EC50 of each drug by 1-3 times.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Interferon-β1b with mycophenolic acid should be considered in treatment trials of MERS.</AbstractText><CopyrightInformation>Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Jasper F W</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Kwok-Hung</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Kao</LastName><ForeName>Richard Y T</ForeName><Initials>RY</Initials></Author><Author ValidYN="Y"><LastName>To</LastName><ForeName>Kelvin K W</ForeName><Initials>KK</Initials></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Bo-Jian</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Clara P Y</ForeName><Initials>CP</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Patrick T W</ForeName><Initials>PT</Initials></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mok</LastName><ForeName>Florence K Y</ForeName><Initials>FK</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Honglin</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Hayden</LastName><ForeName>Frederick G</ForeName><Initials>FG</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057166" MajorTopicYN="N">High-Throughput Screening Assays</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009173" MajorTopicYN="N">Mycophenolic Acid</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName><QualifierName UI="Q000494" 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