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Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Identifieur interne : 000D26 ( PubMed/Checkpoint ); précédent : 000D25; suivant : 000D27

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Auteurs : Neeltje Van Doremalen [États-Unis] ; Darryl Falzarano [États-Unis] ; Tianlei Ying [États-Unis] ; Emmie De Wit [États-Unis] ; Trenton Bushmaker [États-Unis] ; Friederike Feldmann [États-Unis] ; Atsushi Okumura [États-Unis] ; Yanping Wang [États-Unis] ; Dana P. Scott [États-Unis] ; Patrick W. Hanley [États-Unis] ; Heinz Feldmann [États-Unis] ; Dimiter S. Dimitrov [États-Unis] ; Vincent J. Munster [États-Unis]

Source :

Antiviral research [ 1872-9096 ] ; 2017.

RBID : pubmed:28389142

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (usage thérapeutique), Appareil respiratoire (anatomopathologie), Appareil respiratoire (imagerie diagnostique), Appareil respiratoire (virologie), Callithrix (virologie), Charge virale (), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Femelle, Immunisation passive (), Immunisation passive (médecine vétérinaire), Immunohistochimie, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lignée cellulaire, Maladies des singes (anatomopathologie), Maladies des singes (traitement médicamenteux), Maladies des singes (virologie), Modèles animaux de maladie humaine, Mâle, Poumon (anatomopathologie), Poumon (imagerie diagnostique), Poumon (virologie), Radiographie.
MESH :
- anatomopathologie : Appareil respiratoire, Maladies des singes, Poumon.
- imagerie diagnostique : Appareil respiratoire, Poumon.
- immunologie : Anticorps antiviraux.
- médecine vétérinaire : Immunisation passive, Infections à coronavirus.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus, Maladies des singes.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Appareil respiratoire, Callithrix, Infections à coronavirus, Maladies des singes, Poumon.
- Animaux, Charge virale, Femelle, Immunisation passive, Immunohistochimie, Lignée cellulaire, Modèles animaux de maladie humaine, Mâle, Radiographie.

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (therapeutic use), Callithrix (virology), Cell Line, Coronavirus Infections (drug therapy), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Disease Models, Animal, Female, Immunization, Passive (methods), Immunization, Passive (veterinary), Immunohistochemistry, Lung (diagnostic imaging), Lung (pathology), Lung (virology), Male, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Monkey Diseases (drug therapy), Monkey Diseases (pathology), Monkey Diseases (virology), Radiography, Respiratory System (diagnostic imaging), Respiratory System (pathology), Respiratory System (virology), Viral Load (drug effects).
MESH :
- chemical , immunology : Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- diagnostic imaging : Lung, Respiratory System.
- drug effects : Viral Load.
- drug therapy : Coronavirus Infections, Monkey Diseases.
- methods : Immunization, Passive.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- pathology : Lung, Monkey Diseases, Respiratory System.
- veterinary : Coronavirus Infections, Immunization, Passive.
- virology : Callithrix, Coronavirus Infections, Lung, Monkey Diseases, Respiratory System.
- Animals, Cell Line, Disease Models, Animal, Female, Immunohistochemistry, Male, Radiography.

Abstract

Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.

DOI: 10.1016/j.antiviral.2017.03.025
PubMed: 28389142

Affiliations:

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Le document en format XML

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<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibodies, Viral (therapeutic use)</term>
<term>Callithrix (virology)</term>
<term>Cell Line</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Immunization, Passive (methods)</term>
<term>Immunization, Passive (veterinary)</term>
<term>Immunohistochemistry</term>
<term>Lung (diagnostic imaging)</term>
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<term>Lung (virology)</term>
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<front><div type="abstract" xml:lang="en">Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>12</Month>
<Day>15</Day>
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<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>143</Volume>
<PubDate><Year>2017</Year>
<Month>07</Month>
</PubDate>
</JournalIssue>
<Title>Antiviral research</Title>
<ISOAbbreviation>Antiviral Res.</ISOAbbreviation>
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<ArticleTitle>Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.</ArticleTitle>
<Pagination><MedlinePgn>30-37</MedlinePgn>
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<Abstract><AbstractText>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.</AbstractText>
<CopyrightInformation>Copyright © 2017. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Doremalen</LastName>
<ForeName>Neeltje</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Darryl</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Tianlei</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Emmie</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
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<ForeName>Trenton</ForeName>
<Initials>T</Initials>
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<ForeName>Friederike</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA; Department of Microbiology, University of Washington, Seattle, WA, USA.</Affiliation>
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<ForeName>Yanping</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.</Affiliation>
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<ForeName>Dana P</ForeName>
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<ForeName>Patrick W</ForeName>
<Initials>PW</Initials>
<AffiliationInfo><Affiliation>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Feldmann</LastName>
<ForeName>Heinz</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Dimitrov</LastName>
<ForeName>Dimiter S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Munster</LastName>
<ForeName>Vincent J</ForeName>
<Initials>VJ</Initials>
<AffiliationInfo><Affiliation>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA. Electronic address: munstervj@niaid.nih.gov.</Affiliation>
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<Acronym>ImNIH</Acronym>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
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<Grant><GrantID>Z01 BC010701</GrantID>
<Acronym>ImNIH</Acronym>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
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<Month>04</Month>
<Day>05</Day>
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<ReferenceList><Reference><Citation>Int J Infect Dis. 2016 Aug;49:129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27352628</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2016 Sep;22(9):1554-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27532807</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 Jun;89(11):6131-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25810539</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Montana</li>
<li>Washington (État)</li>
</region>
<settlement><li>Seattle</li>
</settlement>
<orgName><li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Montana"><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
</region>
<name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name>
<name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name>
<name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name>
<name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name>
<name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
<name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W" last="Hanley">Patrick W. Hanley</name>
<name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name>
<name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name>
<name sortKey="Scott, Dana P" sort="Scott, Dana P" uniqKey="Scott D" first="Dana P" last="Scott">Dana P. Scott</name>
<name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name>
<name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name>
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</tree>
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   |wiki=    Sante
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   |clé=     pubmed:28389142
   |texte=   Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.
}}

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	Serveur d'exploration MERS
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Serveur d'exploration MERS

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

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