MersV1, PubMed, Corpus, bibRecord, 000D27

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Identifieur interne : 000D27 ( PubMed/Corpus ); précédent : 000D26; suivant : 000D28

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Auteurs : Neeltje Van Doremalen ; Darryl Falzarano ; Tianlei Ying ; Emmie De Wit ; Trenton Bushmaker ; Friederike Feldmann ; Atsushi Okumura ; Yanping Wang ; Dana P. Scott ; Patrick W. Hanley ; Heinz Feldmann ; Dimiter S. Dimitrov ; Vincent J. Munster

Source :

Antiviral research [ 1872-9096 ] ; 2017.

RBID : pubmed:28389142

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (therapeutic use), Callithrix (virology), Cell Line, Coronavirus Infections (drug therapy), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Disease Models, Animal, Female, Immunization, Passive (methods), Immunization, Passive (veterinary), Immunohistochemistry, Lung (diagnostic imaging), Lung (pathology), Lung (virology), Male, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Monkey Diseases (drug therapy), Monkey Diseases (pathology), Monkey Diseases (virology), Radiography, Respiratory System (diagnostic imaging), Respiratory System (pathology), Respiratory System (virology), Viral Load (drug effects).
MESH :
- chemical , immunology : Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- diagnostic imaging : Lung, Respiratory System.
- drug effects : Viral Load.
- drug therapy : Coronavirus Infections, Monkey Diseases.
- methods : Immunization, Passive.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- pathology : Lung, Monkey Diseases, Respiratory System.
- veterinary : Coronavirus Infections, Immunization, Passive.
- virology : Callithrix, Coronavirus Infections, Lung, Monkey Diseases, Respiratory System.
- Animals, Cell Line, Disease Models, Animal, Female, Immunohistochemistry, Male, Radiography.

Abstract

Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.

DOI: 10.1016/j.antiviral.2017.03.025
PubMed: 28389142

Links to Exploration step

pubmed:28389142

Le document en format XML

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<front><div type="abstract" xml:lang="en">Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.</div>
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<Abstract><AbstractText>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.</AbstractText>
<CopyrightInformation>Copyright © 2017. Published by Elsevier B.V.</CopyrightInformation>
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<ArticleIdList><ArticleId IdType="pubmed">28389142</ArticleId>
<ArticleId IdType="pii">S0166-3542(16)30538-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.antiviral.2017.03.025</ArticleId>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24062443</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Transl Med. 2016 Feb 17;8(326):326ra21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26888429</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Infect Dis. 2011 Feb 15;52(4):447-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248066</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Dtsch Dermatol Ges. 2015 Jun;13(6):530-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26018364</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2014 Aug 28;371(9):828-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25162889</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Antimicrob Chemother. 2005 Nov;56(5):919-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16183666</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2016 May 15;213(10):1557-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26941283</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2015 Apr 1;211(7):1038-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25281755</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2013 Apr 18;368(16):1560-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23550601</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Comp Med. 2010 Oct;60(5):389-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21262125</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 Jun;89(11):6117-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25787284</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23401516</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2015 Dec;21(12):2186-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26583829</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Commun. 2015 Sep 15;6:8223</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26370782</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Clin Microbiol Infect Dis. 2005 Jan;24(1):44-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15616839</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Res. 2015 Nov;25(11):1237-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26391698</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Rep. 2016 Aug 19;6:31629</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27538452</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26216974</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Transl Med. 2014 Apr 30;6(234):234ra59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778414</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2014 Jul;88(14):7796-805</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24789777</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2015 Jan 1;211(1):80-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25030060</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2016 Jul 7;22(7):701-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27387881</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Springerplus. 2015 Nov 19;4:709</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26618098</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Euro Surveill. 2012 Sep 27;17(39):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23041020</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Intern Med. 2006 Oct 17;145(8):599-609</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16940336</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26124093</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2018-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778221</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2014 Aug 21;10(8):e1004250</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25144235</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Infect Dis. 2016 Aug;49:129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27352628</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2016 Sep;22(9):1554-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27532807</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 Jun;89(11):6131-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25810539</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

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