Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Identifieur interne : 000346 ( PubMed/Checkpoint ); précédent : 000345; suivant : 000347Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Auteurs : Ivy Widjaja [Pays-Bas] ; Chunyan Wang [Pays-Bas] ; Rien Van Haperen [Pays-Bas] ; Javier Gutiérrez-Álvarez [Espagne] ; Brenda Van Dieren [Pays-Bas] ; Nisreen M A. Okba [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Wentao Li [Pays-Bas] ; Raul Fernandez-Delgado [Espagne] ; Frank Grosveld [Pays-Bas] ; Frank J M. Van Kuppeveld [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Luis Enjuanes [Espagne] ; Dubravka Drabek [Pays-Bas] ; Berend-Jan Bosch [Pays-Bas]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Anticorps neutralisants (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Domaines protéiques, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunisation passive, Infections à coronavirus (), Infections à coronavirus (génétique), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Récepteurs viraux (génétique), Récepteurs viraux (immunologie), Souris, Épitopes (), Épitopes (génétique), Épitopes (immunologie).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Récepteurs viraux, Épitopes.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Récepteurs viraux, Épitopes.
- virologie : Infections à coronavirus.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Domaines protéiques, Glycoprotéine de spicule des coronavirus, Humains, Immunisation passive, Infections à coronavirus, Souris, Épitopes.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Epitopes (chemistry), Epitopes (genetics), Epitopes (immunology), Humans, Immunization, Passive, Mice, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Protein Domains, Receptors, Virus (genetics), Receptors, Virus (immunology), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , chemistry : Epitopes, Spike Glycoprotein, Coronavirus.
- chemical , genetics : Epitopes, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- genetics : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Humans, Immunization, Passive, Mice, Protein Domains.
Abstract
The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.
DOI: 10.1080/22221751.2019.1597644
PubMed: 30938227
Affiliations:
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pubmed:30938227Le document en format XML
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<author><name sortKey="Grosveld, Frank" sort="Grosveld, Frank" uniqKey="Grosveld F" first="Frank" last="Grosveld">Frank Grosveld</name>
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<author><name sortKey="Van Kuppeveld, Frank J M" sort="Van Kuppeveld, Frank J M" uniqKey="Van Kuppeveld F" first="Frank J M" last="Van Kuppeveld">Frank J M. Van Kuppeveld</name>
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<author><name sortKey="Gutierrez Lvarez, Javier" sort="Gutierrez Lvarez, Javier" uniqKey="Gutierrez Lvarez J" first="Javier" last="Gutiérrez-Álvarez">Javier Gutiérrez-Álvarez</name>
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<author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name>
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<country xml:lang="fr">Pays-Bas</country>
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<wicri:noRegion>Rotterdam </wicri:noRegion>
</affiliation>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
<affiliation wicri:level="1"><nlm:affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>e Department of Viroscience , Erasmus Medical Center , Rotterdam </wicri:regionArea>
<wicri:noRegion>Rotterdam </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Wentao" sort="Li, Wentao" uniqKey="Li W" first="Wentao" last="Li">Wentao Li</name>
<affiliation wicri:level="1"><nlm:affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht </wicri:regionArea>
<wicri:noRegion>Utrecht </wicri:noRegion>
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<author><name sortKey="Fernandez Delgado, Raul" sort="Fernandez Delgado, Raul" uniqKey="Fernandez Delgado R" first="Raul" last="Fernandez-Delgado">Raul Fernandez-Delgado</name>
<affiliation wicri:level="1"><nlm:affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid </wicri:regionArea>
<wicri:noRegion>Madrid </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grosveld, Frank" sort="Grosveld, Frank" uniqKey="Grosveld F" first="Frank" last="Grosveld">Frank Grosveld</name>
<affiliation wicri:level="1"><nlm:affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>b Department of Cell Biology , Erasmus MC , Rotterdam </wicri:regionArea>
<wicri:noRegion>Rotterdam </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Kuppeveld, Frank J M" sort="Van Kuppeveld, Frank J M" uniqKey="Van Kuppeveld F" first="Frank J M" last="Van Kuppeveld">Frank J M. Van Kuppeveld</name>
<affiliation wicri:level="1"><nlm:affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht </wicri:regionArea>
<wicri:noRegion>Utrecht </wicri:noRegion>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="1"><nlm:affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>e Department of Viroscience , Erasmus Medical Center , Rotterdam </wicri:regionArea>
<wicri:noRegion>Rotterdam </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<affiliation wicri:level="1"><nlm:affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid </wicri:regionArea>
<wicri:noRegion>Madrid </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drabek, Dubravka" sort="Drabek, Dubravka" uniqKey="Drabek D" first="Dubravka" last="Drabek">Dubravka Drabek</name>
<affiliation wicri:level="1"><nlm:affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>b Department of Cell Biology , Erasmus MC , Rotterdam </wicri:regionArea>
<wicri:noRegion>Rotterdam </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht </wicri:regionArea>
<wicri:noRegion>Utrecht </wicri:noRegion>
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<series><title level="j">Emerging microbes & infections</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (virology)</term>
<term>Epitopes (chemistry)</term>
<term>Epitopes (genetics)</term>
<term>Epitopes (immunology)</term>
<term>Humans</term>
<term>Immunization, Passive</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Protein Domains</term>
<term>Receptors, Virus (genetics)</term>
<term>Receptors, Virus (immunology)</term>
<term>Spike Glycoprotein, Coronavirus (chemistry)</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Domaines protéiques</term>
<term>Glycoprotéine de spicule des coronavirus ()</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains</term>
<term>Immunisation passive</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Récepteurs viraux (génétique)</term>
<term>Récepteurs viraux (immunologie)</term>
<term>Souris</term>
<term>Épitopes ()</term>
<term>Épitopes (génétique)</term>
<term>Épitopes (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term>
<term>Receptors, Virus</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Epitopes</term>
<term>Receptors, Virus</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Récepteurs viraux</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Anticorps neutralisants</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Récepteurs viraux</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Immunization, Passive</term>
<term>Mice</term>
<term>Protein Domains</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Domaines protéiques</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Humains</term>
<term>Immunisation passive</term>
<term>Infections à coronavirus</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30938227</PMID>
<DateCompleted><Year>2019</Year>
<Month>06</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.</ArticleTitle>
<Pagination><MedlinePgn>516-530</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2019.1597644</ELocationID>
<Abstract><AbstractText>The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Widjaja</LastName>
<ForeName>Ivy</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Chunyan</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Haperen</LastName>
<ForeName>Rien</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gutiérrez-Álvarez</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0690-9496</Identifier>
<AffiliationInfo><Affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Dieren</LastName>
<ForeName>Brenda</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Okba</LastName>
<ForeName>Nisreen M A</ForeName>
<Initials>NMA</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-2394-1079</Identifier>
<AffiliationInfo><Affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raj</LastName>
<ForeName>V Stalin</ForeName>
<Initials>VS</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2250-8481</Identifier>
<AffiliationInfo><Affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wentao</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernandez-Delgado</LastName>
<ForeName>Raul</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grosveld</LastName>
<ForeName>Frank</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Kuppeveld</LastName>
<ForeName>Frank J M</ForeName>
<Initials>FJM</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haagmans</LastName>
<ForeName>Bart L</ForeName>
<Initials>BL</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6221-2015</Identifier>
<AffiliationInfo><Affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Enjuanes</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drabek</LastName>
<ForeName>Dubravka</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bosch</LastName>
<ForeName>Berend-Jan</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072417" MajorTopicYN="N">Protein Domains</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">MERS</Keyword>
<Keyword MajorTopicYN="N">antibodies</Keyword>
<Keyword MajorTopicYN="N">spike protein</Keyword>
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</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2005 Jul;79(14):9062-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15994800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Rev Anti Infect Ther. 2006 Feb;4(1):43-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16441208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Apr;84(7):3210-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20071581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Aug 12;333(6044):850-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21798894</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2012 Jun 13;4(138):138ra81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22700957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Oct 1;189(7):3430-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22956577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2013;9(4):e1003312</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23637602</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Aug;87(16):9379-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23785207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Jun;88(12):7045-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24719424</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2018-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778221</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2014 Apr 30;6(234):234ra59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Jul;88(14):7796-805</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24789777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1012-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24857749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2014 Jun 26;370(26):2499-505</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24896817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2014 Oct 2;514(7520):47-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25171469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2014 Nov 06;4:6881</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25375093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26124093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26216974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2015 Jul 28;6:7712</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26218507</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2015 Aug 18;5:13133</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26281793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2015 Nov;25(11):1237-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26391698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2016 Mar 1;213(5):712-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26486634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2016 Mar;490:49-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26828465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2016 Mar 3;531(7592):114-117</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26855426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2016 Feb 10;6:20514</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26861827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pathog Glob Health. 2015;109(8):354-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26924345</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2016 Mar 3;531(7592):118-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26935699</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2016 May 15;213(10):1557-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26941283</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2016 Aug;132:141-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27312105</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2016 Sep;24(9):684-686</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27338027</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2016 Aug 19;6:31629</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27538452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2016 Oct;23(10):899-905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27617430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Virus Res. 2016;96:245-286</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27712626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Opin Ther Targets. 2017 Feb;21(2):131-143</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27936982</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2017 Apr 10;8:15092</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28393837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8508-E8517</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28923942</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2018 Jan;18(1):46-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29063907</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2017 Oct 25;92(4):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29070693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11157-11162</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29073020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2018 Jan 30;92(4):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29093093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2018 Apr 27;92(10):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29514901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2018 Apr 23;14(4):e1007009</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29684066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2018 Aug 21;49(2):363-374.e10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30029854</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2018 Aug 9;174(4):938-952.e13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30096313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Adv. 2018 Aug 08;4(8):eaas9667</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30101189</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
<li>Pays-Bas</li>
</country>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Widjaja, Ivy" sort="Widjaja, Ivy" uniqKey="Widjaja I" first="Ivy" last="Widjaja">Ivy Widjaja</name>
</noRegion>
<name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name>
<name sortKey="Drabek, Dubravka" sort="Drabek, Dubravka" uniqKey="Drabek D" first="Dubravka" last="Drabek">Dubravka Drabek</name>
<name sortKey="Grosveld, Frank" sort="Grosveld, Frank" uniqKey="Grosveld F" first="Frank" last="Grosveld">Frank Grosveld</name>
<name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<name sortKey="Li, Wentao" sort="Li, Wentao" uniqKey="Li W" first="Wentao" last="Li">Wentao Li</name>
<name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name>
<name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
<name sortKey="Van Dieren, Brenda" sort="Van Dieren, Brenda" uniqKey="Van Dieren B" first="Brenda" last="Van Dieren">Brenda Van Dieren</name>
<name sortKey="Van Haperen, Rien" sort="Van Haperen, Rien" uniqKey="Van Haperen R" first="Rien" last="Van Haperen">Rien Van Haperen</name>
<name sortKey="Van Kuppeveld, Frank J M" sort="Van Kuppeveld, Frank J M" uniqKey="Van Kuppeveld F" first="Frank J M" last="Van Kuppeveld">Frank J M. Van Kuppeveld</name>
<name sortKey="Wang, Chunyan" sort="Wang, Chunyan" uniqKey="Wang C" first="Chunyan" last="Wang">Chunyan Wang</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Gutierrez Lvarez, Javier" sort="Gutierrez Lvarez, Javier" uniqKey="Gutierrez Lvarez J" first="Javier" last="Gutiérrez-Álvarez">Javier Gutiérrez-Álvarez</name>
</noRegion>
<name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<name sortKey="Fernandez Delgado, Raul" sort="Fernandez Delgado, Raul" uniqKey="Fernandez Delgado R" first="Raul" last="Fernandez-Delgado">Raul Fernandez-Delgado</name>
</country>
</tree>
</affiliations>
</record>
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