Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Identifieur interne : 000587 ( PubMed/Corpus ); précédent : 000586; suivant : 000588Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Auteurs : Ivy Widjaja ; Chunyan Wang ; Rien Van Haperen ; Javier Gutiérrez-Álvarez ; Brenda Van Dieren ; Nisreen M A. Okba ; V Stalin Raj ; Wentao Li ; Raul Fernandez-Delgado ; Frank Grosveld ; Frank J M. Van Kuppeveld ; Bart L. Haagmans ; Luis Enjuanes ; Dubravka Drabek ; Berend-Jan BoschSource :
- Emerging microbes & infections [ 2222-1751 ] ; 2019.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Epitopes (chemistry), Epitopes (genetics), Epitopes (immunology), Humans, Immunization, Passive, Mice, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Protein Domains, Receptors, Virus (genetics), Receptors, Virus (immunology), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , chemistry : Epitopes, Spike Glycoprotein, Coronavirus.
- chemical , genetics : Epitopes, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- genetics : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Humans, Immunization, Passive, Mice, Protein Domains.
Abstract
The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.
DOI: 10.1080/22221751.2019.1597644
PubMed: 30938227
Links to Exploration step
pubmed:30938227Le document en format XML
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<front><div type="abstract" xml:lang="en">The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.</div>
</front>
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<DateCompleted><Year>2019</Year>
<Month>06</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
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<Issue>1</Issue>
<PubDate><Year>2019</Year>
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</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
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<ArticleTitle>Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.</ArticleTitle>
<Pagination><MedlinePgn>516-530</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2019.1597644</ELocationID>
<Abstract><AbstractText>The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Widjaja</LastName>
<ForeName>Ivy</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Chunyan</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Haperen</LastName>
<ForeName>Rien</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gutiérrez-Álvarez</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
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<AffiliationInfo><Affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Dieren</LastName>
<ForeName>Brenda</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Okba</LastName>
<ForeName>Nisreen M A</ForeName>
<Initials>NMA</Initials>
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<AffiliationInfo><Affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Raj</LastName>
<ForeName>V Stalin</ForeName>
<Initials>VS</Initials>
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<AffiliationInfo><Affiliation>e Department of Viroscience , Erasmus Medical Center , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wentao</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Fernandez-Delgado</LastName>
<ForeName>Raul</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>d Department of Molecular and Cell Biology , National Center for Biotechnology-Spanish National Research Council (CNB-CSIC) , Madrid , Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grosveld</LastName>
<ForeName>Frank</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Kuppeveld</LastName>
<ForeName>Frank J M</ForeName>
<Initials>FJM</Initials>
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<Author ValidYN="Y"><LastName>Haagmans</LastName>
<ForeName>Bart L</ForeName>
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</AffiliationInfo>
</Author>
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<ForeName>Luis</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drabek</LastName>
<ForeName>Dubravka</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>b Department of Cell Biology , Erasmus MC , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Harbour Antibodies B.V. , Rotterdam , Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bosch</LastName>
<ForeName>Berend-Jan</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>a Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht , Netherlands.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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