Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection
Identifieur interne : 001436 ( Pmc/Curation ); précédent : 001435; suivant : 001437Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection
Auteurs : Hui-Ju Han ; Jian-Wei Liu ; Hao Yu ; Xue-Jie YuSource :
- Viruses [ 1999-4915 ] ; 2018.
Abstract
Since emerging in 2012, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has been a global public health threat with a high fatality rate and worldwide distribution. There are no approved vaccines or therapies for MERS until now. Passive immunotherapy with neutralizing monoclonal antibodies (mAbs) is an effective prophylactic and therapeutic reagent against emerging viruses. In this article, we review current advances in neutralizing mAbs against MERS-CoV. The receptor-binding domain (RBD) in the spike protein of MERS-CoV is a major target, and mouse, camel, or human-derived neutralizing mAbs targeting RBD have been developed. A major problem with neutralizing mAb therapy is mutant escape under selective pressure, which can be solved by combination of neutralizing mAbs targeting different epitopes. Neutralizing mAbs are currently under preclinical evaluation, and they are promising candidate therapeutic agents against MERS-CoV infection.
Url:
DOI: 10.3390/v10120680
PubMed: 30513619
PubMed Central: 6315345
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection</title>
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<author><name sortKey="Liu, Jian Wei" sort="Liu, Jian Wei" uniqKey="Liu J" first="Jian-Wei" last="Liu">Jian-Wei Liu</name>
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<front><div type="abstract" xml:lang="en"><p>Since emerging in 2012, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has been a global public health threat with a high fatality rate and worldwide distribution. There are no approved vaccines or therapies for MERS until now. Passive immunotherapy with neutralizing monoclonal antibodies (mAbs) is an effective prophylactic and therapeutic reagent against emerging viruses. In this article, we review current advances in neutralizing mAbs against MERS-CoV. The receptor-binding domain (RBD) in the spike protein of MERS-CoV is a major target, and mouse, camel, or human-derived neutralizing mAbs targeting RBD have been developed. A major problem with neutralizing mAb therapy is mutant escape under selective pressure, which can be solved by combination of neutralizing mAbs targeting different epitopes. Neutralizing mAbs are currently under preclinical evaluation, and they are promising candidate therapeutic agents against MERS-CoV infection.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Viruses</journal-id>
<journal-id journal-id-type="iso-abbrev">Viruses</journal-id>
<journal-id journal-id-type="publisher-id">viruses</journal-id>
<journal-title-group><journal-title>Viruses</journal-title>
</journal-title-group>
<issn pub-type="epub">1999-4915</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30513619</article-id>
<article-id pub-id-type="pmc">6315345</article-id>
<article-id pub-id-type="doi">10.3390/v10120680</article-id>
<article-id pub-id-type="publisher-id">viruses-10-00680</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1923-5128</contrib-id>
<name><surname>Han</surname>
<given-names>Hui-Ju</given-names>
</name>
<xref ref-type="aff" rid="af1-viruses-10-00680">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jian-Wei</given-names>
</name>
<xref ref-type="aff" rid="af1-viruses-10-00680">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Hao</given-names>
</name>
<xref ref-type="aff" rid="af2-viruses-10-00680">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Xue-Jie</given-names>
</name>
<xref ref-type="aff" rid="af1-viruses-10-00680">1</xref>
<xref rid="c1-viruses-10-00680" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-viruses-10-00680"><label>1</label>
School of Health Sciences, and State Key Laboratory of Virology, Wuhan University, Wuhan 430071, China;<email>nikihuijuhan@163.com</email>
(H.-J.H.);<email>liujw_2012@163.com</email>
(J.-W.L.)</aff>
<aff id="af2-viruses-10-00680"><label>2</label>
Fudan University School of Medicine, Shanghai 200032, China;<email>howardyu89@163.com</email>
</aff>
<author-notes><corresp id="c1-viruses-10-00680"><label>*</label>
Correspondence: <email>yuxuejie@whu.edu.cn</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>30</day>
<month>11</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="collection"><month>12</month>
<year>2018</year>
</pub-date>
<volume>10</volume>
<issue>12</issue>
<elocation-id>680</elocation-id>
<history><date date-type="received"><day>19</day>
<month>11</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>29</day>
<month>11</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>© 2018 by the authors.</copyright-statement>
<copyright-year>2018</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>Since emerging in 2012, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has been a global public health threat with a high fatality rate and worldwide distribution. There are no approved vaccines or therapies for MERS until now. Passive immunotherapy with neutralizing monoclonal antibodies (mAbs) is an effective prophylactic and therapeutic reagent against emerging viruses. In this article, we review current advances in neutralizing mAbs against MERS-CoV. The receptor-binding domain (RBD) in the spike protein of MERS-CoV is a major target, and mouse, camel, or human-derived neutralizing mAbs targeting RBD have been developed. A major problem with neutralizing mAb therapy is mutant escape under selective pressure, which can be solved by combination of neutralizing mAbs targeting different epitopes. Neutralizing mAbs are currently under preclinical evaluation, and they are promising candidate therapeutic agents against MERS-CoV infection.</p>
</abstract>
<kwd-group><kwd>Middle East Respiratory Syndrome Virus</kwd>
<kwd>MERS-CoV</kwd>
<kwd>neutralizing monoclonal antibodies</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="viruses-10-00680-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>(<bold>A</bold>
) Schematic representation of MERS-CoV S protein. (<bold>B</bold>
) Residues on RBD critical for mAb neutralization. SP: signal peptide; NTD: N-terminal domain; RBD: receptor-binding domain; RBM: receptor-binding motif. Conserved residues on RBM critical for hDPP4 binding are shown in red.</p>
</caption>
<graphic xlink:href="viruses-10-00680-g001"></graphic>
</fig>
</floats-group>
</pmc>
</record>
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