The structure and functions of coronavirus genomic 3′ and 5′ ends
Identifieur interne : 001430 ( Pmc/Curation ); précédent : 001429; suivant : 001431The structure and functions of coronavirus genomic 3′ and 5′ ends
Auteurs : Dong Yang [États-Unis] ; Julian L. Leibowitz [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2015.
Abstract
Models of conserved 5′ and 3′ betacoronavirus The 5′ All 3′ A putative molecular switch is present in the coronavirus 3′UTR. Proteins interacting with these
Url:
DOI: 10.1016/j.virusres.2015.02.025
PubMed: 25736566
PubMed Central: 4476908
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The structure and functions of coronavirus genomic 3′ and 5′ ends</title><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38163, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38163</wicri:regionArea></affiliation></author><author><name sortKey="Leibowitz, Julian L" sort="Leibowitz, Julian L" uniqKey="Leibowitz J" first="Julian L." last="Leibowitz">Julian L. Leibowitz</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, College Station, TX 77843-1114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, College Station, TX 77843-1114</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25736566</idno><idno type="pmc">4476908</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476908</idno><idno type="RBID">PMC:4476908</idno><idno type="doi">10.1016/j.virusres.2015.02.025</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001430</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001430</idno><idno type="wicri:Area/Pmc/Curation">001430</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The structure and functions of coronavirus genomic 3′ and 5′ ends</title><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38163, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38163</wicri:regionArea></affiliation></author><author><name sortKey="Leibowitz, Julian L" sort="Leibowitz, Julian L" uniqKey="Leibowitz J" first="Julian L." last="Leibowitz">Julian L. Leibowitz</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, College Station, TX 77843-1114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, College Station, TX 77843-1114</wicri:regionArea></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Models of conserved 5′ and 3′ betacoronavirus <italic>cis</italic>-acting RNA secondary structures are presented.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">The 5′ <italic>cis</italic>-acting sequences required for coronavirus replication extend into the first open reading frame.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">All 3′ <italic>cis</italic>-acting sequences required for coronavirus replication are contained in the 3′UTR.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">A putative molecular switch is present in the coronavirus 3′UTR.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Proteins interacting with these <italic>cis</italic>-acting regions are reviewed.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arbour, N" uniqKey="Arbour N">N. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Res</journal-id><journal-id journal-id-type="iso-abbrev">Virus Res</journal-id><journal-title-group><journal-title>Virus Research</journal-title></journal-title-group><issn pub-type="ppub">0168-1702</issn><issn pub-type="epub">1872-7492</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25736566</article-id><article-id pub-id-type="pmc">4476908</article-id><article-id pub-id-type="publisher-id">S0168-1702(15)00115-X</article-id><article-id pub-id-type="doi">10.1016/j.virusres.2015.02.025</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The structure and functions of coronavirus genomic 3′ and 5′ ends</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Yang</surname><given-names>Dong</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Leibowitz</surname><given-names>Julian L.</given-names></name><email>jleibowitz@tamu.edu</email><xref rid="aff0010" ref-type="aff">b</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38163, USA</aff><aff id="aff0010"><label>b</label>Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, College Station, TX 77843-1114, USA</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Department of Microbial Pathogenesis and Immunology, Texas A&M University, College of Medicine, 407 Reynolds Medical Building, 1114 TAMU, College Station, TX 77843-1114, USA. Tel.: +1 979 436 0313; fax: +1 979 845 3479. <email>jleibowitz@tamu.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>28</day><month>2</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>3</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>2</month><year>2015</year></pub-date><volume>206</volume><fpage>120</fpage><lpage>133</lpage><permissions><copyright-statement>Copyright © 2015 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Models of conserved 5′ and 3′ betacoronavirus <italic>cis</italic>-acting RNA secondary structures are presented.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">The 5′ <italic>cis</italic>-acting sequences required for coronavirus replication extend into the first open reading frame.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">All 3′ <italic>cis</italic>-acting sequences required for coronavirus replication are contained in the 3′UTR.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">A putative molecular switch is present in the coronavirus 3′UTR.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Proteins interacting with these <italic>cis</italic>-acting regions are reviewed.</p></list-item></list></p></abstract><abstract id="abs0010"><p>Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most human coronaviruses commonly cause relatively mild respiratory illnesses; however two zoonotic coronaviruses, SARS-CoV and MERS-CoV, can cause severe illness and death. Investigations over the past 35 years have illuminated many aspects of coronavirus replication. The focus of this review is the functional analysis of conserved RNA secondary structures in the 5′ and 3′ of the betacoronavirus genomes. The 5′ 350 nucleotides folds into a set of RNA secondary structures which are well conserved, and reverse genetic studies indicate that these structures play an important role in the discontinuous synthesis of subgenomic RNAs in the betacoronaviruses. These <italic>cis</italic>-acting elements extend 3′ of the 5′UTR into ORF1a. The 3′UTR is similarly conserved and contains all of the <italic>cis</italic>-acting sequences necessary for viral replication. Two competing conformations near the 5′ end of the 3′UTR have been shown to make up a potential molecular switch. There is some evidence that an association between the 3′ and 5′UTRs is necessary for subgenomic RNA synthesis, but the basis for this association is not yet clear. A number of host RNA proteins have been shown to bind to the 5′ and 3′ <italic>cis</italic>-acting regions, but the significance of these in viral replication is not clear. Two viral proteins have been identified as binding to the 5′ <italic>cis</italic>-acting region, nsp1 and N protein. A genetic interaction between nsp8 and nsp9 and the region of the 3′UTR that contains the putative molecular switch suggests that these two proteins bind to this region.</p></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Coronaviruses</kwd><kwd>RNA secondary structure</kwd><kwd><italic>cis</italic>-Acting sequences</kwd><kwd>Virus replication</kwd><kwd>RNA binding proteins</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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