Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
Identifieur interne : 001141 ( Pmc/Curation ); précédent : 001140; suivant : 001142Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
Auteurs : V. Stalin Raj [Pays-Bas] ; Nisreen M. A. Okba [Pays-Bas] ; Javier Gutierrez-Alvarez [Espagne] ; Dubravka Drabek [Pays-Bas] ; Brenda Van Dieren [Pays-Bas] ; W. Widagdo [Pays-Bas] ; Mart M. Lamers [Pays-Bas] ; Ivy Widjaja [Pays-Bas] ; Raul Fernandez-Delgado [Espagne] ; Isabel Sola [Espagne] ; Albert Bensaid [Espagne] ; Marion P. Koopmans [Pays-Bas] ; Joaquim Segalés [Espagne] ; Albert D. M. E. Osterhaus [Pays-Bas, Allemagne] ; Berend Jan Bosch [Pays-Bas] ; Luis Enjuanes [Espagne] ; Bart L. Haagmans [Pays-Bas]Source :
- Science Advances [ 2375-2548 ] ; 2018.
Abstract
Dromedary camel heavy chain–only antibodies may provide novel intervention strategies against MERS coronavirus.
Url:
DOI: 10.1126/sciadv.aas9667
PubMed: 30101189
PubMed Central: 6082650
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001141
Links to Exploration step
PMC:6082650Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection</title><author><name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M. A." last="Okba">Nisreen M. A. Okba</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Gutierrez Alvarez, Javier" sort="Gutierrez Alvarez, Javier" uniqKey="Gutierrez Alvarez J" first="Javier" last="Gutierrez-Alvarez">Javier Gutierrez-Alvarez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Drabek, Dubravka" sort="Drabek, Dubravka" uniqKey="Drabek D" first="Dubravka" last="Drabek">Dubravka Drabek</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Cell Biology, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cell Biology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Dieren, Brenda" sort="Van Dieren, Brenda" uniqKey="Van Dieren B" first="Brenda" last="Van Dieren">Brenda Van Dieren</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W." last="Widagdo">W. Widagdo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M." last="Lamers">Mart M. Lamers</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Widjaja, Ivy" sort="Widjaja, Ivy" uniqKey="Widjaja I" first="Ivy" last="Widjaja">Ivy Widjaja</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Delgado, Raul" sort="Fernandez Delgado, Raul" uniqKey="Fernandez Delgado R" first="Raul" last="Fernandez-Delgado">Raul Fernandez-Delgado</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name><affiliation wicri:level="1"><nlm:aff id="aff5">Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Marion P" sort="Koopmans, Marion P" uniqKey="Koopmans M" first="Marion P." last="Koopmans">Marion P. Koopmans</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name><affiliation wicri:level="1"><nlm:aff id="aff6">UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra</wicri:regionArea></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="1"><nlm:aff id="aff8">Artemis One Health, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Artemis One Health, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend Jan" last="Bosch">Berend Jan Bosch</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30101189</idno><idno type="pmc">6082650</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082650</idno><idno type="RBID">PMC:6082650</idno><idno type="doi">10.1126/sciadv.aas9667</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">001141</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001141</idno><idno type="wicri:Area/Pmc/Curation">001141</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001141</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection</title><author><name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M. A." last="Okba">Nisreen M. A. Okba</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Gutierrez Alvarez, Javier" sort="Gutierrez Alvarez, Javier" uniqKey="Gutierrez Alvarez J" first="Javier" last="Gutierrez-Alvarez">Javier Gutierrez-Alvarez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Drabek, Dubravka" sort="Drabek, Dubravka" uniqKey="Drabek D" first="Dubravka" last="Drabek">Dubravka Drabek</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Cell Biology, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cell Biology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Dieren, Brenda" sort="Van Dieren, Brenda" uniqKey="Van Dieren B" first="Brenda" last="Van Dieren">Brenda Van Dieren</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W." last="Widagdo">W. Widagdo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M." last="Lamers">Mart M. Lamers</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Widjaja, Ivy" sort="Widjaja, Ivy" uniqKey="Widjaja I" first="Ivy" last="Widjaja">Ivy Widjaja</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Delgado, Raul" sort="Fernandez Delgado, Raul" uniqKey="Fernandez Delgado R" first="Raul" last="Fernandez-Delgado">Raul Fernandez-Delgado</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name><affiliation wicri:level="1"><nlm:aff id="aff5">Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Marion P" sort="Koopmans, Marion P" uniqKey="Koopmans M" first="Marion P." last="Koopmans">Marion P. Koopmans</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name><affiliation wicri:level="1"><nlm:aff id="aff6">UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra</wicri:regionArea></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="1"><nlm:aff id="aff8">Artemis One Health, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Artemis One Health, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend Jan" last="Bosch">Berend Jan Bosch</name><affiliation wicri:level="1"><nlm:aff id="aff4">Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Science Advances</title><idno type="eISSN">2375-2548</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Dromedary camel heavy chain–only antibodies may provide novel intervention strategies against MERS coronavirus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A. M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T. M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R. A. M. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S. Cauchemez</name></author><author><name sortKey="Nouvellet, P" uniqKey="Nouvellet P">P. Nouvellet</name></author><author><name sortKey="Cori, A" uniqKey="Cori A">A. Cori</name></author><author><name sortKey="Jombart, T" uniqKey="Jombart T">T. Jombart</name></author><author><name sortKey="Garske, T" uniqKey="Garske T">T. Garske</name></author><author><name sortKey="Clapham, H" uniqKey="Clapham H">H. Clapham</name></author><author><name sortKey="Moore, S" uniqKey="Moore S">S. Moore</name></author><author><name sortKey="Mills, H L" uniqKey="Mills H">H. L. Mills</name></author><author><name sortKey="Salje, H" uniqKey="Salje H">H. Salje</name></author><author><name sortKey="Collins, C" uniqKey="Collins C">C. Collins</name></author><author><name sortKey="Rodriquez Barraquer, I" uniqKey="Rodriquez Barraquer I">I. Rodriquez-Barraquer</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S. Riley</name></author><author><name sortKey="Truelove, S" uniqKey="Truelove S">S. Truelove</name></author><author><name sortKey="Algarni, H" uniqKey="Algarni H">H. Algarni</name></author><author><name sortKey="Alhakeem, R" uniqKey="Alhakeem R">R. Alhakeem</name></author><author><name sortKey="Alharbi, K" uniqKey="Alharbi K">K. AlHarbi</name></author><author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A. Turkistani</name></author><author><name sortKey="Aguas, R J" uniqKey="Aguas R">R. J. Aguas</name></author><author><name sortKey="Cummings, D A T" uniqKey="Cummings D">D. A. T. Cummings</name></author><author><name sortKey="Van Kerkhove, M D" uniqKey="Van Kerkhove M">M. D. Van Kerkhove</name></author><author><name sortKey="Donnelly, C A" uniqKey="Donnelly C">C. A. Donnelly</name></author><author><name sortKey="Lessler, J" uniqKey="Lessler J">J. Lessler</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A. Al-Barrak</name></author><author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N. M. Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V. S. Raj</name></author><author><name sortKey="Farag, E A B A" uniqKey="Farag E">E. A. B. A. Farag</name></author><author><name sortKey="Reusken, C B E M" uniqKey="Reusken C">C. B. E. M. Reusken</name></author><author><name sortKey="Lamers, M M" uniqKey="Lamers M">M. M. Lamers</name></author><author><name sortKey="Pas, S D" uniqKey="Pas S">S. D. Pas</name></author><author><name sortKey="Voermans, J" uniqKey="Voermans J">J. Voermans</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S. L. Smits</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Al Mawlawi, N" uniqKey="Al Mawlawi N">N. Al-Mawlawi</name></author><author><name sortKey="Al Romaihi, H E" uniqKey="Al Romaihi H">H. E. Al-Romaihi</name></author><author><name sortKey="Alhajri, M M" uniqKey="Alhajri M">M. M. AlHajri</name></author><author><name sortKey="El Sayed, A M" uniqKey="El Sayed A">A. M. El-Sayed</name></author><author><name sortKey="Mohran, K A" uniqKey="Mohran K">K. A. Mohran</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H. Ghobashy</name></author><author><name sortKey="Alhajri, F" uniqKey="Alhajri F">F. Alhajri</name></author><author><name sortKey="Al Thani, M" uniqKey="Al Thani M">M. Al-Thani</name></author><author><name sortKey="Al Marri, S A" uniqKey="Al Marri S">S. A. Al-Marri</name></author><author><name sortKey="El Maghraby, M M" uniqKey="El Maghraby M">M. M. El-Maghraby</name></author><author><name sortKey="Koopmans, M P G" uniqKey="Koopmans M">M. P. G. Koopmans</name></author><author><name sortKey="Haagmans, Bart L" uniqKey="Haagmans B">Bart L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author><author><name sortKey="Watson, S J" uniqKey="Watson S">S. J. Watson</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P. Kellam</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A. A. Al-Rabeeah</name></author><author><name sortKey="Makhdoom, H Q" uniqKey="Makhdoom H">H. Q. Makhdoom</name></author><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J. A. Al-Tawfiq</name></author><author><name sortKey="Alhakeem, R F" uniqKey="Alhakeem R">R. F. Alhakeem</name></author><author><name sortKey="Madani, H" uniqKey="Madani H">H. Madani</name></author><author><name sortKey="Alrabiah, F A" uniqKey="Alrabiah F">F. A. AlRabiah</name></author><author><name sortKey="Hajjar, S A" uniqKey="Hajjar S">S. A. Hajjar</name></author><author><name sortKey="Al Nassir, W N" uniqKey="Al Nassir W">W. N. Al-nassir</name></author><author><name sortKey="Albarrak, A" uniqKey="Albarrak A">A. Albarrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H. Flemban</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H. H. Balkhy</name></author><author><name sortKey="Alsubaie, S" uniqKey="Alsubaie S">S. Alsubaie</name></author><author><name sortKey="Palser, A L" uniqKey="Palser A">A. L. Palser</name></author><author><name sortKey="Gall, A" uniqKey="Gall A">A. Gall</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z. A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, X C" uniqKey="Tang X">X.-C. Tang</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S. S. Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y. Jiao</name></author><author><name sortKey="Stanhope, J" uniqKey="Stanhope J">J. Stanhope</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R. L. Graham</name></author><author><name sortKey="Peterson, E C" uniqKey="Peterson E">E. C. Peterson</name></author><author><name sortKey="Avnir, Y" uniqKey="Avnir Y">Y. Avnir</name></author><author><name sortKey="St Clair Tallarico, A" uniqKey="St Clair Tallarico A">A. St. Clair Tallarico</name></author><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J. Sheehan</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q. Zhu</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R. S. Baric</name></author><author><name sortKey="Marasco, W A" uniqKey="Marasco W">W. A. Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D. Corti</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Pedotti, M" uniqKey="Pedotti M">M. Pedotti</name></author><author><name sortKey="Simonelli, L" uniqKey="Simonelli L">L. Simonelli</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C. Fett</name></author><author><name sortKey="Fernandez Rodriguez, B" uniqKey="Fernandez Rodriguez B">B. Fernandez-Rodriguez</name></author><author><name sortKey="Foglierini, M" uniqKey="Foglierini M">M. Foglierini</name></author><author><name sortKey="Agatic, G" uniqKey="Agatic G">G. Agatic</name></author><author><name sortKey="Vanzetta, F" uniqKey="Vanzetta F">F. Vanzetta</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R. Gopal</name></author><author><name sortKey="Langrish, C J" uniqKey="Langrish C">C. J. Langrish</name></author><author><name sortKey="Barrett, N A" uniqKey="Barrett N">N. A. Barrett</name></author><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F. Sallusto</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R. S. Baric</name></author><author><name sortKey="Varani, L" uniqKey="Varani L">L. Varani</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M. Zambon</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A. Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, K E" uniqKey="Pascal K">K. E. Pascal</name></author><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C. M. Coleman</name></author><author><name sortKey="Mujica, A O" uniqKey="Mujica A">A. O. Mujica</name></author><author><name sortKey="Kamat, V" uniqKey="Kamat V">V. Kamat</name></author><author><name sortKey="Badithe, A" uniqKey="Badithe A">A. Badithe</name></author><author><name sortKey="Fairhurst, J" uniqKey="Fairhurst J">J. Fairhurst</name></author><author><name sortKey="Hunt, C" uniqKey="Hunt C">C. Hunt</name></author><author><name sortKey="Strein, J" uniqKey="Strein J">J. Strein</name></author><author><name sortKey="Berrebi, A" uniqKey="Berrebi A">A. Berrebi</name></author><author><name sortKey="Sisk, J M" uniqKey="Sisk J">J. M. Sisk</name></author><author><name sortKey="Matthews, K L" uniqKey="Matthews K">K. L. Matthews</name></author><author><name sortKey="Babb, R" uniqKey="Babb R">R. Babb</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Lai, K M V" uniqKey="Lai K">K.-M. V. Lai</name></author><author><name sortKey="Huang, T T" uniqKey="Huang T">T. T. Huang</name></author><author><name sortKey="Olson, W" uniqKey="Olson W">W. Olson</name></author><author><name sortKey="Yancopoulos, G D" uniqKey="Yancopoulos G">G. D. Yancopoulos</name></author><author><name sortKey="Stahl, N" uniqKey="Stahl N">N. Stahl</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M. B. Frieman</name></author><author><name sortKey="Kyratsous, C A" uniqKey="Kyratsous C">C. A. Kyratsous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V. S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S. L. Smits</name></author><author><name sortKey="Dekkers, D H W" uniqKey="Dekkers D">D. H. W. Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M. A. Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Demmers, J A A" uniqKey="Demmers J">J. A. A. Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R. A. M. Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P. J. M. Rottier</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B. J. Bosch</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V. S. Raj</name></author><author><name sortKey="Van Kuppeveld, F J M" uniqKey="Van Kuppeveld F">F. J. M. van Kuppeveld</name></author><author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P. J. M. Rottier</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B. J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Amri, S S" uniqKey="Al Amri S">S. S. Al-amri</name></author><author><name sortKey="Abbas, A T" uniqKey="Abbas A">A. T. Abbas</name></author><author><name sortKey="Siddiq, L A" uniqKey="Siddiq L">L. A. Siddiq</name></author><author><name sortKey="Alghamdi, A" uniqKey="Alghamdi A">A. Alghamdi</name></author><author><name sortKey="Sanki, M A" uniqKey="Sanki M">M. A. Sanki</name></author><author><name sortKey="Al Muhanna, M K" uniqKey="Al Muhanna M">M. K. Al-Muhanna</name></author><author><name sortKey="Alhabbab, R Y" uniqKey="Alhabbab R">R. Y. Alhabbab</name></author><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E. I. Azhar</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Hashem, A M" uniqKey="Hashem A">A. M. Hashem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y. Wan</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P. Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G. F. Gao</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Zuo, T" uniqKey="Zuo T">T. Zuo</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Poon, K M V" uniqKey="Poon K">K.-M. V. Poon</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J. Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.-J. Zheng</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, A S" uniqKey="Agrawal A">A. S. Agrawal</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T. Ying</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T. Garron</name></author><author><name sortKey="Algaissi, A" uniqKey="Algaissi A">A. Algaissi</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Peng, B H" uniqKey="Peng B">B.-H. Peng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Dimitrov, D S" uniqKey="Dimitrov D">D. S. Dimitrov</name></author><author><name sortKey="Tseng, C T K" uniqKey="Tseng C">C.-T. K. Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chames, P" uniqKey="Chames P">P. Chames</name></author><author><name sortKey="Van Regenmortel, M" uniqKey="Van Regenmortel M">M. Van Regenmortel</name></author><author><name sortKey="Weiss, E" uniqKey="Weiss E">E. Weiss</name></author><author><name sortKey="Baty, D" uniqKey="Baty D">D. Baty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spadiut, O" uniqKey="Spadiut O">O. Spadiut</name></author><author><name sortKey="Capone, S" uniqKey="Capone S">S. Capone</name></author><author><name sortKey="Krainer, F" uniqKey="Krainer F">F. Krainer</name></author><author><name sortKey="Glieder, A" uniqKey="Glieder A">A. Glieder</name></author><author><name sortKey="Herwig, C" uniqKey="Herwig C">C. Herwig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Irani, V" uniqKey="Irani V">V. Irani</name></author><author><name sortKey="Guy, A J" uniqKey="Guy A">A. J. Guy</name></author><author><name sortKey="Andrew, D" uniqKey="Andrew D">D. Andrew</name></author><author><name sortKey="Beeson, J G" uniqKey="Beeson J">J. G. Beeson</name></author><author><name sortKey="Ramsland, P A" uniqKey="Ramsland P">P. A. Ramsland</name></author><author><name sortKey="Richards, J S" uniqKey="Richards J">J. S. Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamers Casterman, C" uniqKey="Hamers Casterman C">C. Hamers-Casterman</name></author><author><name sortKey="Atarhouch, T" uniqKey="Atarhouch T">T. Atarhouch</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author><author><name sortKey="Robinson, G" uniqKey="Robinson G">G. Robinson</name></author><author><name sortKey="Hammers, C" uniqKey="Hammers C">C. Hammers</name></author><author><name sortKey="Songa, E B" uniqKey="Songa E">E. B. Songa</name></author><author><name sortKey="Bendahman, N" uniqKey="Bendahman N">N. Bendahman</name></author><author><name sortKey="Hammers, R" uniqKey="Hammers R">R. Hammers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Genst, E" uniqKey="De Genst E">E. De Genst</name></author><author><name sortKey="Silence, K" uniqKey="Silence K">K. Silence</name></author><author><name sortKey="Decanniere, K" uniqKey="Decanniere K">K. Decanniere</name></author><author><name sortKey="Conrath, K" uniqKey="Conrath K">K. Conrath</name></author><author><name sortKey="Loris, R" uniqKey="Loris R">R. Loris</name></author><author><name sortKey="Kinne, J" uniqKey="Kinne J">J. Kinne</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author><author><name sortKey="Wyns, L" uniqKey="Wyns L">L. Wyns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothbauer, U" uniqKey="Rothbauer U">U. Rothbauer</name></author><author><name sortKey="Zolghadr, K" uniqKey="Zolghadr K">K. Zolghadr</name></author><author><name sortKey="Tillib, S" uniqKey="Tillib S">S. Tillib</name></author><author><name sortKey="Nowak, D" uniqKey="Nowak D">D. Nowak</name></author><author><name sortKey="Schermelleh, L" uniqKey="Schermelleh L">L. Schermelleh</name></author><author><name sortKey="Gahl, A" uniqKey="Gahl A">A. Gahl</name></author><author><name sortKey="Backmann, N" uniqKey="Backmann N">N. Backmann</name></author><author><name sortKey="Conrath, K" uniqKey="Conrath K">K. Conrath</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author><author><name sortKey="Cardoso, M C" uniqKey="Cardoso M">M. C. Cardoso</name></author><author><name sortKey="Leonhardt, H" uniqKey="Leonhardt H">H. Leonhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hassanzadeh Ghassabeh, G" uniqKey="Hassanzadeh Ghassabeh G">G. Hassanzadeh-Ghassabeh</name></author><author><name sortKey="Devoogdt, N" uniqKey="Devoogdt N">N. Devoogdt</name></author><author><name sortKey="De Pauw, P" uniqKey="De Pauw P">P. De Pauw</name></author><author><name sortKey="Vincke, C" uniqKey="Vincke C">C. Vincke</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peyvandi, F" uniqKey="Peyvandi F">F. Peyvandi</name></author><author><name sortKey="Scully, M" uniqKey="Scully M">M. Scully</name></author><author><name sortKey="Kremer Hovinga, J A" uniqKey="Kremer Hovinga J">J. A. Kremer Hovinga</name></author><author><name sortKey="Cataland, S" uniqKey="Cataland S">S. Cataland</name></author><author><name sortKey="Knobl, P" uniqKey="Knobl P">P. Knöbl</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H. Wu</name></author><author><name sortKey="Artoni, A" uniqKey="Artoni A">A. Artoni</name></author><author><name sortKey="Westwood, J P" uniqKey="Westwood J">J. P. Westwood</name></author><author><name sortKey="Mansouri Taleghani, M" uniqKey="Mansouri Taleghani M">M. Mansouri Taleghani</name></author><author><name sortKey="Jilma, B" uniqKey="Jilma B">B. Jilma</name></author><author><name sortKey="Callewaert, F" uniqKey="Callewaert F">F. Callewaert</name></author><author><name sortKey="Ulrichts, H" uniqKey="Ulrichts H">H. Ulrichts</name></author><author><name sortKey="Duby, C" uniqKey="Duby C">C. Duby</name></author><author><name sortKey="Tersago, D" uniqKey="Tersago D">D. Tersago</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanlandschoot, P" uniqKey="Vanlandschoot P">P. Vanlandschoot</name></author><author><name sortKey="Stortelers, C" uniqKey="Stortelers C">C. Stortelers</name></author><author><name sortKey="Beirnaert, E" uniqKey="Beirnaert E">E. Beirnaert</name></author><author><name sortKey="Iba Ez, L I" uniqKey="Iba Ez L">L. I. Ibañez</name></author><author><name sortKey="Schepens, B" uniqKey="Schepens B">B. Schepens</name></author><author><name sortKey="Depla, E" uniqKey="Depla E">E. Depla</name></author><author><name sortKey="Saelens, X" uniqKey="Saelens X">X. Saelens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farag, E A B A" uniqKey="Farag E">E. A. B. A. Farag</name></author><author><name sortKey="Reusken, C B E M" uniqKey="Reusken C">C. B. E. M. Reusken</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Mohran, K A" uniqKey="Mohran K">K. A. Mohran</name></author><author><name sortKey="Stalin Raj, V" uniqKey="Stalin Raj V">V. Stalin Raj</name></author><author><name sortKey="Pas, S D" uniqKey="Pas S">S. D. Pas</name></author><author><name sortKey="Voermans, J" uniqKey="Voermans J">J. Voermans</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S. L. Smits</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.-J. Godeke</name></author><author><name sortKey="Al Hajri, M M" uniqKey="Al Hajri M">M. M. Al-Hajri</name></author><author><name sortKey="Alhajri, F H" uniqKey="Alhajri F">F. H. Alhajri</name></author><author><name sortKey="Al Romaihi, H E" uniqKey="Al Romaihi H">H. E. Al-Romaihi</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H. Ghobashy</name></author><author><name sortKey="El Maghraby, M M" uniqKey="El Maghraby M">M. M. El-Maghraby</name></author><author><name sortKey="El Sayed, A M" uniqKey="El Sayed A">A. M. El-Sayed</name></author><author><name sortKey="Al Thani, M H J" uniqKey="Al Thani M">M. H. J. Al Thani</name></author><author><name sortKey="Al Marri, S" uniqKey="Al Marri S">S. Al-Marri</name></author><author><name sortKey="Koopmans, M P G" uniqKey="Koopmans M">M. P. G. Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, C B E M" uniqKey="Reusken C">C. B. E. M. Reusken</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M. A. Müller</name></author><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C. Gutierrez</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.-J. Godeke</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Stalin Raj, V" uniqKey="Stalin Raj V">V. Stalin Raj</name></author><author><name sortKey="Smits De Vries, L" uniqKey="Smits De Vries L">L. Smits-De Vries</name></author><author><name sortKey="Corman, V M" uniqKey="Corman V">V. M. Corman</name></author><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J.-F. Drexler</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S. L. Smits</name></author><author><name sortKey="El Tahir, Y E" uniqKey="El Tahir Y">Y. E. El Tahir</name></author><author><name sortKey="De Sousa, R" uniqKey="De Sousa R">R. De Sousa</name></author><author><name sortKey="Van Beek, J" uniqKey="Van Beek J">J. van Beek</name></author><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N. Nowotny</name></author><author><name sortKey="Van Maanen, K" uniqKey="Van Maanen K">K. van Maanen</name></author><author><name sortKey="Hidalgo Hermoso, E" uniqKey="Hidalgo Hermoso E">E. Hidalgo-Hermoso</name></author><author><name sortKey="Koopmans, M P G" uniqKey="Koopmans M">M. P. G. Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, M A" uniqKey="Muller M">M. A. Müller</name></author><author><name sortKey="Corman, V M" uniqKey="Corman V">V. M. Corman</name></author><author><name sortKey="Jores, J" uniqKey="Jores J">J. Jores</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name></author><author><name sortKey="Younan, M" uniqKey="Younan M">M. Younan</name></author><author><name sortKey="Liljander, A M" uniqKey="Liljander A">A. M. Liljander</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.-J. Bosch</name></author><author><name sortKey="Lattwein, E" uniqKey="Lattwein E">E. Lattwein</name></author><author><name sortKey="Hilali, M" uniqKey="Hilali M">M. Hilali</name></author><author><name sortKey="Musa, B E" uniqKey="Musa B">B. E. Musa</name></author><author><name sortKey="Bornstein, S" uniqKey="Bornstein S">S. Bornstein</name></author><author><name sortKey="Park, S S" uniqKey="Park S">S. S. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Van Den Brand, J M A" uniqKey="Van Den Brand J">J. M. A. van den Brand,</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pardon, E" uniqKey="Pardon E">E. Pardon</name></author><author><name sortKey="Laeremans, T" uniqKey="Laeremans T">T. Laeremans</name></author><author><name sortKey="Triest, S" uniqKey="Triest S">S. Triest</name></author><author><name sortKey="Rasmussen, S G F" uniqKey="Rasmussen S">S. G. F. Rasmussen</name></author><author><name sortKey="Wohlkonig, A" uniqKey="Wohlkonig A">A. Wohlkönig</name></author><author><name sortKey="Ruf, A" uniqKey="Ruf A">A. Ruf</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author><author><name sortKey="Hol, W G J" uniqKey="Hol W">W. G. J. Hol</name></author><author><name sortKey="Kobilka, B K" uniqKey="Kobilka B">B. K. Kobilka</name></author><author><name sortKey="Steyaert, J" uniqKey="Steyaert J">J. Steyaert</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chakravarty, R" uniqKey="Chakravarty R">R. Chakravarty</name></author><author><name sortKey="Goel, S" uniqKey="Goel S">S. Goel</name></author><author><name sortKey="Cai, W" uniqKey="Cai W">W. Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P. Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Arledge, K C" uniqKey="Arledge K">K. C. Arledge</name></author><author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y.-H. Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J. Bao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y. Shi</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G. F. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C. Wohlford-Lenane</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Jewell, A K" uniqKey="Jewell A">A. K. Jewell</name></author><author><name sortKey="Reznikov, L R" uniqKey="Reznikov L">L. R. Reznikov</name></author><author><name sortKey="Gibson Corley, K N" uniqKey="Gibson Corley K">K. N. Gibson-Corley</name></author><author><name sortKey="Meyerholz, D K" uniqKey="Meyerholz D">D. K. Meyerholz</name></author><author><name sortKey="Mccray, P B" uniqKey="Mccray P">P. B. McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, F I" uniqKey="Schmidt F">F. I. Schmidt</name></author><author><name sortKey="Hanke, L" uniqKey="Hanke L">L. Hanke</name></author><author><name sortKey="Morin, B" uniqKey="Morin B">B. Morin</name></author><author><name sortKey="Brewer, R" uniqKey="Brewer R">R. Brewer</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author><author><name sortKey="Whelan, S P J" uniqKey="Whelan S">S. P. J. Whelan</name></author><author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H. L. Ploegh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Al Dhahiry, S H S" uniqKey="Al Dhahiry S">S. H. S. Al Dhahiry</name></author><author><name sortKey="Reusken, C B E M" uniqKey="Reusken C">C. B. E. M Reusken</name></author><author><name sortKey="Stalin Raj, V" uniqKey="Stalin Raj V">V. Stalin Raj</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M. Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R. Myers</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.-J. Godeke</name></author><author><name sortKey="Jonges, M" uniqKey="Jonges M">M. Jonges</name></author><author><name sortKey="Farag, E" uniqKey="Farag E">E. Farag</name></author><author><name sortKey="Diab, A" uniqKey="Diab A">A. Diab</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H. Ghobashy</name></author><author><name sortKey="Alhajri, F" uniqKey="Alhajri F">F. Alhajri</name></author><author><name sortKey="Al Thani, M" uniqKey="Al Thani M">M. Al-Thani</name></author><author><name sortKey="Al Marri, S A" uniqKey="Al Marri S">S. A. Al-Marri</name></author><author><name sortKey="Al Romaihi, H E" uniqKey="Al Romaihi H">H. E. Al Romaihi</name></author><author><name sortKey="Khal, A A" uniqKey="Khal A">A. A. Khal</name></author><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A. Bermingham</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Koopmans, M P G" uniqKey="Koopmans M">M. P. G. Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radbruch, A" uniqKey="Radbruch A">A. Radbruch</name></author><author><name sortKey="Muehlinghaus, G" uniqKey="Muehlinghaus G">G. Muehlinghaus</name></author><author><name sortKey="Luger, E O" uniqKey="Luger E">E. O. Luger</name></author><author><name sortKey="Inamine, A" uniqKey="Inamine A">A. Inamine</name></author><author><name sortKey="Smith, K G C" uniqKey="Smith K">K. G. C. Smith</name></author><author><name sortKey="Dorner, T" uniqKey="Dorner T">T. Dörner</name></author><author><name sortKey="Hiepe, F" uniqKey="Hiepe F">F. Hiepe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellyard, J I" uniqKey="Ellyard J">J. I. Ellyard</name></author><author><name sortKey="Avery, D T" uniqKey="Avery D">D. T. Avery</name></author><author><name sortKey="Phan, T G" uniqKey="Phan T">T. G. Phan</name></author><author><name sortKey="Hare, N J" uniqKey="Hare N">N. J. Hare</name></author><author><name sortKey="Hodgkin, P D" uniqKey="Hodgkin P">P. D. Hodgkin</name></author><author><name sortKey="Tangye, S G" uniqKey="Tangye S">S. G. Tangye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paramithiotis, E" uniqKey="Paramithiotis E">E. Paramithiotis</name></author><author><name sortKey="Cooper, M D" uniqKey="Cooper M">M. D. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manz, R A" uniqKey="Manz R">R. A. Manz</name></author><author><name sortKey="Hauser, A E" uniqKey="Hauser A">A. E. Hauser</name></author><author><name sortKey="Hiepe, F" uniqKey="Hiepe F">F. Hiepe</name></author><author><name sortKey="Radbruch, A" uniqKey="Radbruch A">A. Radbruch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, V K" uniqKey="Nguyen V">V. K. Nguyen</name></author><author><name sortKey="Hamers, R" uniqKey="Hamers R">R. Hamers</name></author><author><name sortKey="Wyns, L" uniqKey="Wyns L">L. Wyns</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T. Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Ju, T W" uniqKey="Ju T">T. W. Ju</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P. Prabakaran</name></author><author><name sortKey="Lau, C C Y" uniqKey="Lau C">C. C. Y. Lau</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.-J. Zheng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Dimitrov, D S" uniqKey="Dimitrov D">D. S. Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sok, D" uniqKey="Sok D">D. Sok</name></author><author><name sortKey="Le, K M" uniqKey="Le K">K. M. Le</name></author><author><name sortKey="Vadnais, M" uniqKey="Vadnais M">M. Vadnais</name></author><author><name sortKey="Saye Francisco, K L" uniqKey="Saye Francisco K">K. L. Saye-Francisco</name></author><author><name sortKey="Jardine, J G" uniqKey="Jardine J">J. G. Jardine</name></author><author><name sortKey="Torres, J L" uniqKey="Torres J">J. L. Torres</name></author><author><name sortKey="Berndsen, Z T" uniqKey="Berndsen Z">Z. T. Berndsen</name></author><author><name sortKey="Kong, L" uniqKey="Kong L">L. Kong</name></author><author><name sortKey="Stanfield, R" uniqKey="Stanfield R">R. Stanfield</name></author><author><name sortKey="Ruiz, J" uniqKey="Ruiz J">J. Ruiz</name></author><author><name sortKey="Ramos, A" uniqKey="Ramos A">A. Ramos</name></author><author><name sortKey="Liang, C H" uniqKey="Liang C">C.-H. Liang</name></author><author><name sortKey="Chen, P L" uniqKey="Chen P">P. L. Chen</name></author><author><name sortKey="Criscitiello, M F" uniqKey="Criscitiello M">M. F. Criscitiello</name></author><author><name sortKey="Mwangi, W" uniqKey="Mwangi W">W. Mwangi</name></author><author><name sortKey="Wilson, I A" uniqKey="Wilson I">I. A. Wilson</name></author><author><name sortKey="Ward, A B" uniqKey="Ward A">A. B. Ward</name></author><author><name sortKey="Smider, V V" uniqKey="Smider V">V. V. Smider</name></author><author><name sortKey="Burton, D R" uniqKey="Burton D">D. R. Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sim Es, E A F" uniqKey="Sim Es E">E. A. F. Simões</name></author><author><name sortKey="Devincenzo, J P" uniqKey="Devincenzo J">J. P. DeVincenzo</name></author><author><name sortKey="Boeckh, M" uniqKey="Boeckh M">M. Boeckh</name></author><author><name sortKey="Bont, L" uniqKey="Bont L">L. Bont</name></author><author><name sortKey="Crowe, J E" uniqKey="Crowe J">J. E. Crowe</name></author><author><name sortKey="Griffiths, P" uniqKey="Griffiths P">P. Griffiths</name></author><author><name sortKey="Hayden, F G" uniqKey="Hayden F">F. G. Hayden</name></author><author><name sortKey="Hodinka, R L" uniqKey="Hodinka R">R. L. Hodinka</name></author><author><name sortKey="Smyth, R L" uniqKey="Smyth R">R. L. Smyth</name></author><author><name sortKey="Spencer, K" uniqKey="Spencer K">K. Spencer</name></author><author><name sortKey="Thirstrup, S" uniqKey="Thirstrup S">S. Thirstrup</name></author><author><name sortKey="Walsh, E E" uniqKey="Walsh E">E. E. Walsh</name></author><author><name sortKey="Whitley, R J" uniqKey="Whitley R">R. J. Whitley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name></author><author><name sortKey="Provacia, L B" uniqKey="Provacia L">L. B. Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G. Sutter</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nakabayashi, H" uniqKey="Nakabayashi H">H. Nakabayashi</name></author><author><name sortKey="Taketa, K" uniqKey="Taketa K">K. Taketa</name></author><author><name sortKey="Miyano, K" uniqKey="Miyano K">K. Miyano</name></author><author><name sortKey="Yamane, T" uniqKey="Yamane T">T. Yamane</name></author><author><name sortKey="Sato, J" uniqKey="Sato J">J. Sato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M. de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C. Lauber</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T. M. Bestebroer</name></author><author><name sortKey="Stalin Raj, V" uniqKey="Stalin Raj V">V. Stalin Raj</name></author><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A. M. Zaki</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A. E. Gorbalenya</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E. J. Snijder</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R. A. M. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smits, S L" uniqKey="Smits S">S. L. Smits</name></author><author><name sortKey="De Lang, A" uniqKey="De Lang A">A. de Lang</name></author><author><name sortKey="Van Den Brand, J M A" uniqKey="Van Den Brand J">J. M. A. van den Brand</name></author><author><name sortKey="Leijten, L M" uniqKey="Leijten L">L. M. Leijten</name></author><author><name sortKey="Van Ijcken, W F" uniqKey="Van Ijcken W">W. F. van IJcken</name></author><author><name sortKey="Eijkemans, M J C" uniqKey="Eijkemans M">M. J. C. Eijkemans</name></author><author><name sortKey="Vanamerongen, G" uniqKey="Vanamerongen G">G. vanAmerongen</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Andeweg, A C" uniqKey="Andeweg A">A. C. Andeweg</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Kuppeveld, F J" uniqKey="Van Kuppeveld F">F. J. van Kuppeveld</name></author><author><name sortKey="Van Der Logt, J T" uniqKey="Van Der Logt J">J. T. van der Logt</name></author><author><name sortKey="Angulo, A F" uniqKey="Angulo A">A. F. Angulo</name></author><author><name sortKey="Van Zoest, M J" uniqKey="Van Zoest M">M. J. van Zoest</name></author><author><name sortKey="Quint, W G" uniqKey="Quint W">W. G. Quint</name></author><author><name sortKey="Niesters, H G" uniqKey="Niesters H">H. G. Niesters</name></author><author><name sortKey="Galama, J M" uniqKey="Galama J">J. M. Galama</name></author><author><name sortKey="Melchers, W J" uniqKey="Melchers W">W. J. Melchers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. Haagmans</name></author><author><name sortKey="Van Den Brand, J M A" uniqKey="Van Den Brand J">J. M. A. van den Brand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdiche, Y N" uniqKey="Abdiche Y">Y. N. Abdiche</name></author><author><name sortKey="Malashock, D S" uniqKey="Malashock D">D. S. Malashock</name></author><author><name sortKey="Pinkerton, A" uniqKey="Pinkerton A">A. Pinkerton</name></author><author><name sortKey="Pons, J" uniqKey="Pons J">J. Pons</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Adv</journal-id><journal-id journal-id-type="iso-abbrev">Sci Adv</journal-id><journal-id journal-id-type="publisher-id">SciAdv</journal-id><journal-id journal-id-type="hwp">advances</journal-id><journal-title-group><journal-title>Science Advances</journal-title></journal-title-group><issn pub-type="epub">2375-2548</issn><publisher><publisher-name>American Association for the Advancement of Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30101189</article-id><article-id pub-id-type="pmc">6082650</article-id><article-id pub-id-type="publisher-id">aas9667</article-id><article-id pub-id-type="doi">10.1126/sciadv.aas9667</article-id><article-categories><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group><subj-group subj-group-type="legacy-article-type"><subject>SciAdv r-articles</subject></subj-group><subj-group subj-group-type="field"><subject>Life Sciences</subject></subj-group><subj-group subj-group-type="overline"><subject>Immunology</subject></subj-group></article-categories><title-group><article-title>Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-2250-8481</contrib-id><name><surname>Stalin Raj</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref><xref ref-type="author-notes" rid="afn2">†</xref><xref ref-type="corresp" rid="cor1">‡</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-2394-1079</contrib-id><name><surname>Okba</surname><given-names>Nisreen M. A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-0690-9496</contrib-id><name><surname>Gutierrez-Alvarez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Drabek</surname><given-names>Dubravka</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-7665-683X</contrib-id><name><surname>van Dieren</surname><given-names>Brenda</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Widagdo</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lamers</surname><given-names>Mart M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Widjaja</surname><given-names>Ivy</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-7411-9010</contrib-id><name><surname>Fernandez-Delgado</surname><given-names>Raul</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-5704-1917</contrib-id><name><surname>Sola</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bensaid</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-5204-2312</contrib-id><name><surname>Koopmans</surname><given-names>Marion P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-1539-7261</contrib-id><name><surname>Segalés</surname><given-names>Joaquim</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Osterhaus</surname><given-names>Albert D. M. E.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-3864-232X</contrib-id><name><surname>Bosch</surname><given-names>Berend Jan</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-0854-0226</contrib-id><name><surname>Enjuanes</surname><given-names>Luis</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-6221-2015</contrib-id><name><surname>Haagmans</surname><given-names>Bart L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">‡</xref></contrib><aff id="aff1"><label>1</label>Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.</aff><aff id="aff2"><label>2</label>Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.</aff><aff id="aff3"><label>3</label>Department of Cell Biology, Erasmus Medical Center, Rotterdam, Netherlands.</aff><aff id="aff4"><label>4</label>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</aff><aff id="aff5"><label>5</label>Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra, Spain.</aff><aff id="aff6"><label>6</label>UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain.</aff><aff id="aff7"><label>7</label>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Spain.</aff><aff id="aff8"><label>8</label>Artemis One Health, Utrecht, Netherlands.</aff><aff id="aff9"><label>9</label>Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover, Germany.</aff></contrib-group><author-notes><fn id="afn1" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn><fn id="afn2" fn-type="present-address"><label>†</label><p>Present address: School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM), Kerala, India.</p></fn><corresp id="cor1"><label>‡</label>Corresponding author. Email: <email xlink:href="stalin@iisertvm.ac.in">stalin@iisertvm.ac.in</email> (V.S.R.); <email xlink:href="b.haagmans@erasmusmc.nl">b.haagmans@erasmusmc.nl</email> (B.L.H.)</corresp></author-notes><pub-date pub-type="collection"><month>8</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>08</day><month>8</month><year>2018</year></pub-date><volume>4</volume><issue>8</issue><elocation-id>eaas9667</elocation-id><history><date date-type="received"><day>29</day><month>1</month><year>2018</year></date><date date-type="accepted"><day>01</day><month>7</month><year>2018</year></date></history><permissions><copyright-statement>Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</copyright-statement><copyright-year>2018</copyright-year><copyright-holder>The Authors</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" id="p-2"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial license</ext-link>, which permits use, distribution, and reproduction in any medium, so long as the resultant use is <bold>not</bold> for commercial advantage and provided the original work is properly cited.</license-p></license></permissions><abstract abstract-type="teaser"><p>Dromedary camel heavy chain–only antibodies may provide novel intervention strategies against MERS coronavirus.</p></abstract><abstract><p>Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause outbreaks in humans as a result of spillover events from dromedaries. In contrast to humans, MERS-CoV–exposed dromedaries develop only very mild infections and exceptionally potent virus-neutralizing antibody responses. These strong antibody responses may be caused by affinity maturation as a result of repeated exposure to the virus or by the fact that dromedaries—apart from conventional antibodies—have relatively unique, heavy chain–only antibodies (HCAbs). These HCAbs are devoid of light chains and have long complementarity-determining regions with unique epitope binding properties, allowing them to recognize and bind with high affinity to epitopes not recognized by conventional antibodies. Through direct cloning and expression of the variable heavy chains (VHHs) of HCAbs from the bone marrow of MERS-CoV–infected dromedaries, we identified several MERS-CoV–specific VHHs or nanobodies. In vitro, these VHHs efficiently blocked virus entry at picomolar concentrations. The selected VHHs bind with exceptionally high affinity to the receptor binding domain of the viral spike protein. Furthermore, camel/human chimeric HCAbs—composed of the camel VHH linked to a human Fc domain lacking the CH1 exon—had an extended half-life in the serum and protected mice against a lethal MERS-CoV challenge. HCAbs represent a promising alternative strategy to develop novel interventions not only for MERS-CoV but also for other emerging pathogens.</p></abstract><funding-group><award-group id="award402490"><funding-source><institution-wrap><institution-id institution-id-type="doi">http://dx.doi.org/10.13039/100000002</institution-id><institution>National Institutes of Health</institution></institution-wrap></funding-source><award-id>2PO1AIO6O699</award-id></award-group><award-group id="award402488"><funding-source><institution-wrap><institution-id institution-id-type="doi">http://dx.doi.org/10.13039/100010661</institution-id><institution>Horizon 2020 Framework Programme</institution></institution-wrap></funding-source><award-id>653316</award-id></award-group><award-group id="award402487"><funding-source><institution-wrap><institution>Zoonotic Anticipation and Preparedness Initiative</institution></institution-wrap></funding-source><award-id>IMI Grant Agreement no. 115760</award-id></award-group><award-group id="award402489"><funding-source><institution-wrap><institution>Ministry of Science and Innovation, Spain</institution></institution-wrap></funding-source><award-id>Bio2016-75549-R AEI/FEDER, UE</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>Copyeditor</meta-name><meta-value>Jeanelle Ebreo</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001141 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001141 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:6082650
|texte= Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:30101189" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |