Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011–2016
Identifieur interne : 000E55 ( Pmc/Curation ); précédent : 000E54; suivant : 000E56Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011–2016
Auteurs : Afnan A. Degnah [Arabie saoudite] ; Sawsan S. Al-Amri [Arabie saoudite] ; Ahmed M. Hassan [Arabie saoudite] ; Abdulrahman S. Almasoud [Arabie saoudite] ; Manar Mousa [Arabie saoudite] ; Sarah A. Almahboub [Arabie saoudite] ; Rowa Y. Alhabbab [Arabie saoudite] ; Ahmed A. Mirza [Arabie saoudite] ; Salwa I. Hindawi [Arabie saoudite] ; Naif Khalaf Alharbi [Arabie saoudite] ; Esam I. Azhar [Arabie saoudite] ; Anwar M. Hashem [Arabie saoudite]Source :
- Journal of Infection and Public Health [ 1876-0341 ] ; 2020.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized zoonotic coronavirus. Current evidence confirms the role of dromedaries in primary human infections but does not explain the sporadic community cases. However, asymptomatic or subclinical cases could represent a possible source of infection in the community.
Archived human sera (7461) collected between 2011 and 2016 from healthy adult blood donors from 50 different nationalities in the western part of Saudi Arabia were obtained for MERS-CoV seroprevalence investigation. Samples were tested for MERS-CoV S1-specific antibodies (Abs) by ELISA and confirmed by testing for neutralizing Abs (nAbs) using both pseudotyped and live virus neutralization assays.
Out of 7461 samples, 174 sera from individuals with 18 different nationalities were ELISA positive (2.3%, 95% CI 2.0–2.7). Presence of nAbs was confirmed in 17 samples (0.23%, 95% CI 0.1–0.4) of which one sample exhibited positivity in both neutralization assays. Confirmed seropositivity was identified in young (15–44 years) men and women from Saudi Arabia, Egypt, Yemen, Pakistan, Palestine, Sudan, and India without significant preference.
An increasing trend of MERS-CoV seroprevalence was observed in the general population in western Saudi Arabia, suggesting that asymptomatic or mild infections might exist and act as an unrecognized source of infection. Seropositivity of individuals from different nationalities underscores the potential MERS exportation outside of the Arabian Peninsula. Thus, enhanced and continuous surveillance is highly warranted.
Url:
DOI: 10.1016/j.jiph.2020.01.001
PubMed: 32005618
PubMed Central: 7104088
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<author><name sortKey="Al Amri, Sawsan S" sort="Al Amri, Sawsan S" uniqKey="Al Amri S" first="Sawsan S." last="Al-Amri">Sawsan S. Al-Amri</name>
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<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
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<author><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I." last="Azhar">Esam I. Azhar</name>
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<author><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M." last="Hashem">Anwar M. Hashem</name>
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<series><title level="j">Journal of Infection and Public Health</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized zoonotic coronavirus. Current evidence confirms the role of dromedaries in primary human infections but does not explain the sporadic community cases. However, asymptomatic or subclinical cases could represent a possible source of infection in the community.</p>
</sec>
<sec><title>Methods</title>
<p>Archived human sera (7461) collected between 2011 and 2016 from healthy adult blood donors from 50 different nationalities in the western part of Saudi Arabia were obtained for MERS-CoV seroprevalence investigation. Samples were tested for MERS-CoV S1-specific antibodies (Abs) by ELISA and confirmed by testing for neutralizing Abs (nAbs) using both pseudotyped and live virus neutralization assays.</p>
</sec>
<sec><title>Results</title>
<p>Out of 7461 samples, 174 sera from individuals with 18 different nationalities were ELISA positive (2.3%, 95% CI 2.0–2.7). Presence of nAbs was confirmed in 17 samples (0.23%, 95% CI 0.1–0.4) of which one sample exhibited positivity in both neutralization assays. Confirmed seropositivity was identified in young (15–44 years) men and women from Saudi Arabia, Egypt, Yemen, Pakistan, Palestine, Sudan, and India without significant preference.</p>
</sec>
<sec><title>Conclusions</title>
<p>An increasing trend of MERS-CoV seroprevalence was observed in the general population in western Saudi Arabia, suggesting that asymptomatic or mild infections might exist and act as an unrecognized source of infection. Seropositivity of individuals from different nationalities underscores the potential MERS exportation outside of the Arabian Peninsula. Thus, enhanced and continuous surveillance is highly warranted.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id>
<journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id>
<journal-title-group><journal-title>Journal of Infection and Public Health</journal-title>
</journal-title-group>
<issn pub-type="ppub">1876-0341</issn>
<issn pub-type="epub">1876-035X</issn>
<publisher><publisher-name>Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32005618</article-id>
<article-id pub-id-type="pmc">7104088</article-id>
<article-id pub-id-type="publisher-id">S1876-0341(20)30001-0</article-id>
<article-id pub-id-type="doi">10.1016/j.jiph.2020.01.001</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011–2016</article-title>
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<contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Degnah</surname>
<given-names>Afnan A.</given-names>
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<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
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<given-names>Sawsan S.</given-names>
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<xref rid="aff0015" ref-type="aff">c</xref>
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<given-names>Ahmed M.</given-names>
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<given-names>Sarah A.</given-names>
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<given-names>Salwa I.</given-names>
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<xref rid="aff0030" ref-type="aff">f</xref>
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<given-names>Naif Khalaf</given-names>
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<xref rid="aff0020" ref-type="aff">d</xref>
<xref rid="aff0035" ref-type="aff">g</xref>
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<given-names>Esam I.</given-names>
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<email>eazhar@kau.edu.sa</email>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
<xref rid="cor0010" ref-type="corresp">⁎⁎</xref>
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<contrib contrib-type="author" id="aut0060"><name><surname>Hashem</surname>
<given-names>Anwar M.</given-names>
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<email>amhashem@kau.edu.sa</email>
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<xref rid="aff0025" ref-type="aff">e</xref>
<xref rid="cor0005" ref-type="corresp">⁎</xref>
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</contrib-group>
<aff id="aff0005"><label>a</label>
Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="aff0010"><label>b</label>
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="aff0015"><label>c</label>
Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="aff0020"><label>d</label>
Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</aff>
<aff id="aff0025"><label>e</label>
Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="aff0030"><label>f</label>
Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
<aff id="aff0035"><label>g</label>
King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia</aff>
<author-notes><corresp id="cor0005"><label>⁎</label>
Corresponding author at: Faculty of Medicine and King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80205, Jeddah 21859, Saudi Arabia. <email>amhashem@kau.edu.sa</email>
</corresp>
<corresp id="cor0010"><label>⁎⁎</label>
Corresponding author at: Faculty of Applied Medical Sciences and King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80205, Jeddah 21859, Saudi Arabia. <email>eazhar@kau.edu.sa</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>28</day>
<month>1</month>
<year>2020</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>28</day>
<month>1</month>
<year>2020</year>
</pub-date>
<elocation-id></elocation-id>
<history><date date-type="received"><day>27</day>
<month>9</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>4</day>
<month>12</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>15</day>
<month>1</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder></copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0005"><sec><title>Background</title>
<p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized zoonotic coronavirus. Current evidence confirms the role of dromedaries in primary human infections but does not explain the sporadic community cases. However, asymptomatic or subclinical cases could represent a possible source of infection in the community.</p>
</sec>
<sec><title>Methods</title>
<p>Archived human sera (7461) collected between 2011 and 2016 from healthy adult blood donors from 50 different nationalities in the western part of Saudi Arabia were obtained for MERS-CoV seroprevalence investigation. Samples were tested for MERS-CoV S1-specific antibodies (Abs) by ELISA and confirmed by testing for neutralizing Abs (nAbs) using both pseudotyped and live virus neutralization assays.</p>
</sec>
<sec><title>Results</title>
<p>Out of 7461 samples, 174 sera from individuals with 18 different nationalities were ELISA positive (2.3%, 95% CI 2.0–2.7). Presence of nAbs was confirmed in 17 samples (0.23%, 95% CI 0.1–0.4) of which one sample exhibited positivity in both neutralization assays. Confirmed seropositivity was identified in young (15–44 years) men and women from Saudi Arabia, Egypt, Yemen, Pakistan, Palestine, Sudan, and India without significant preference.</p>
</sec>
<sec><title>Conclusions</title>
<p>An increasing trend of MERS-CoV seroprevalence was observed in the general population in western Saudi Arabia, suggesting that asymptomatic or mild infections might exist and act as an unrecognized source of infection. Seropositivity of individuals from different nationalities underscores the potential MERS exportation outside of the Arabian Peninsula. Thus, enhanced and continuous surveillance is highly warranted.</p>
</sec>
</abstract>
<kwd-group id="kwd0005"><title>Keywords</title>
<kwd>MERS-CoV</kwd>
<kwd>Blood donors</kwd>
<kwd>Seroprevalence</kwd>
<kwd>Saudi Arabia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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