Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates
Identifieur interne : 000B81 ( Pmc/Curation ); précédent : 000B80; suivant : 000B82Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates
Auteurs : Farida Ismail Al Hosani [Émirats arabes unis] ; Lindsay Kim [Géorgie (pays), États-Unis] ; Ahmed Khudhair [Émirats arabes unis] ; Huong Pham [Géorgie (pays)] ; Mariam Al Mulla [Émirats arabes unis] ; Zyad Al Bandar [Émirats arabes unis] ; Krishna Pradeep [Émirats arabes unis] ; Kheir Abou Elkheir [Émirats arabes unis] ; Stefan Weber [Émirats arabes unis] ; Mary Khoury [Émirats arabes unis] ; George Donnelly [Émirats arabes unis] ; Naima Younis [Émirats arabes unis] ; Feda El Saleh [Émirats arabes unis] ; Muna Abdalla [Émirats arabes unis] ; Hala Imambaccus [Émirats arabes unis] ; Lia M. Haynes [Géorgie (pays)] ; Natalie J. Thornburg [Géorgie (pays)] ; Jennifer L. Harcourt [Géorgie (pays)] ; Congrong Miao [Géorgie (pays)] ; Azaibi Tamin [Géorgie (pays)] ; Aron J. Hall [Géorgie (pays)] ; Elizabeth S. Russell [Géorgie (pays)] ; Aaron M. Harris [États-Unis, Géorgie (pays)] ; Craig Kiebler [Géorgie (pays)] ; Roger A. Mir [Géorgie (pays)] ; Kimberly Pringle [Géorgie (pays)] ; Negar N. Alami [Géorgie (pays)] ; Glen R. Abedi [Géorgie (pays)] ; Susan I. Gerber [Géorgie (pays)]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2018.
Abstract
Although there is evidence of person-to-person transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent to which disease severity affects transmission.
A seroepidemiological investigation was conducted among MERS-CoV case patients (cases) and their household contacts to investigate transmission risk in Abu Dhabi, United Arab Emirates. Cases diagnosed between 1 January 2013 and 9 May 2014 and their household contacts were approached for enrollment. Demographic, clinical, and exposure history data were collected. Sera were screened by MERS-CoV nucleocapsid protein enzyme-linked immunosorbent assay and indirect immunofluorescence, with results confirmed by microneutralization assay.
Thirty-one of 34 (91%) case patients were asymptomatic or mildly symptomatic and did not require oxygen during hospitalization. MERS-CoV antibodies were detected in 13 of 24 (54%) case patients with available sera, including 1 severely symptomatic, 9 mildly symptomatic, and 3 asymptomatic case patients. No serologic evidence of MERS-CoV transmission was found among 105 household contacts with available sera.
Transmission of MERS-CoV was not documented in this investigation of mostly asymptomatic and mildly symptomatic cases and their household contacts. These results have implications for clinical management of cases and formulation of isolation policies to reduce the risk of transmission.
Url:
DOI: 10.1093/cid/ciy503
PubMed: 29905769
PubMed Central: 7108211
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B81
Links to Exploration step
PMC:7108211Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates</title>
<author><name sortKey="Al Hosani, Farida Ismail" sort="Al Hosani, Farida Ismail" uniqKey="Al Hosani F" first="Farida Ismail" last="Al Hosani">Farida Ismail Al Hosani</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Lindsay" sort="Kim, Lindsay" uniqKey="Kim L" first="Lindsay" last="Kim">Lindsay Kim</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="AF0003">United States Public Health Service, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>United States Public Health Service, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khudhair, Ahmed" sort="Khudhair, Ahmed" uniqKey="Khudhair A" first="Ahmed" last="Khudhair">Ahmed Khudhair</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pham, Huong" sort="Pham, Huong" uniqKey="Pham H" first="Huong" last="Pham">Huong Pham</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Mulla, Mariam" sort="Al Mulla, Mariam" uniqKey="Al Mulla M" first="Mariam" last="Al Mulla">Mariam Al Mulla</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Bandar, Zyad" sort="Al Bandar, Zyad" uniqKey="Al Bandar Z" first="Zyad" last="Al Bandar">Zyad Al Bandar</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pradeep, Krishna" sort="Pradeep, Krishna" uniqKey="Pradeep K" first="Krishna" last="Pradeep">Krishna Pradeep</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elkheir, Kheir Abou" sort="Elkheir, Kheir Abou" uniqKey="Elkheir K" first="Kheir Abou" last="Elkheir">Kheir Abou Elkheir</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weber, Stefan" sort="Weber, Stefan" uniqKey="Weber S" first="Stefan" last="Weber">Stefan Weber</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khoury, Mary" sort="Khoury, Mary" uniqKey="Khoury M" first="Mary" last="Khoury">Mary Khoury</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donnelly, George" sort="Donnelly, George" uniqKey="Donnelly G" first="George" last="Donnelly">George Donnelly</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Younis, Naima" sort="Younis, Naima" uniqKey="Younis N" first="Naima" last="Younis">Naima Younis</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="El Saleh, Feda" sort="El Saleh, Feda" uniqKey="El Saleh F" first="Feda" last="El Saleh">Feda El Saleh</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abdalla, Muna" sort="Abdalla, Muna" uniqKey="Abdalla M" first="Muna" last="Abdalla">Muna Abdalla</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imambaccus, Hala" sort="Imambaccus, Hala" uniqKey="Imambaccus H" first="Hala" last="Imambaccus">Hala Imambaccus</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M" last="Haynes">Lia M. Haynes</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J" last="Thornburg">Natalie J. Thornburg</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harcourt, Jennifer L" sort="Harcourt, Jennifer L" uniqKey="Harcourt J" first="Jennifer L" last="Harcourt">Jennifer L. Harcourt</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miao, Congrong" sort="Miao, Congrong" uniqKey="Miao C" first="Congrong" last="Miao">Congrong Miao</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hall, Aron J" sort="Hall, Aron J" uniqKey="Hall A" first="Aron J" last="Hall">Aron J. Hall</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Elizabeth S" sort="Russell, Elizabeth S" uniqKey="Russell E" first="Elizabeth S" last="Russell">Elizabeth S. Russell</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Aaron M" sort="Harris, Aaron M" uniqKey="Harris A" first="Aaron M" last="Harris">Aaron M. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="AF0003">United States Public Health Service, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>United States Public Health Service, Rockville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kiebler, Craig" sort="Kiebler, Craig" uniqKey="Kiebler C" first="Craig" last="Kiebler">Craig Kiebler</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mir, Roger A" sort="Mir, Roger A" uniqKey="Mir R" first="Roger A" last="Mir">Roger A. Mir</name>
<affiliation wicri:level="1"><nlm:aff id="AF0006">Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pringle, Kimberly" sort="Pringle, Kimberly" uniqKey="Pringle K" first="Kimberly" last="Pringle">Kimberly Pringle</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N" last="Alami">Negar N. Alami</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abedi, Glen R" sort="Abedi, Glen R" uniqKey="Abedi G" first="Glen R" last="Abedi">Glen R. Abedi</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I" last="Gerber">Susan I. Gerber</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">29905769</idno>
<idno type="pmc">7108211</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108211</idno>
<idno type="RBID">PMC:7108211</idno>
<idno type="doi">10.1093/cid/ciy503</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Pmc/Corpus">000B81</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B81</idno>
<idno type="wicri:Area/Pmc/Curation">000B81</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B81</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates</title>
<author><name sortKey="Al Hosani, Farida Ismail" sort="Al Hosani, Farida Ismail" uniqKey="Al Hosani F" first="Farida Ismail" last="Al Hosani">Farida Ismail Al Hosani</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Lindsay" sort="Kim, Lindsay" uniqKey="Kim L" first="Lindsay" last="Kim">Lindsay Kim</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="AF0003">United States Public Health Service, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>United States Public Health Service, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khudhair, Ahmed" sort="Khudhair, Ahmed" uniqKey="Khudhair A" first="Ahmed" last="Khudhair">Ahmed Khudhair</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pham, Huong" sort="Pham, Huong" uniqKey="Pham H" first="Huong" last="Pham">Huong Pham</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Mulla, Mariam" sort="Al Mulla, Mariam" uniqKey="Al Mulla M" first="Mariam" last="Al Mulla">Mariam Al Mulla</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Bandar, Zyad" sort="Al Bandar, Zyad" uniqKey="Al Bandar Z" first="Zyad" last="Al Bandar">Zyad Al Bandar</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pradeep, Krishna" sort="Pradeep, Krishna" uniqKey="Pradeep K" first="Krishna" last="Pradeep">Krishna Pradeep</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elkheir, Kheir Abou" sort="Elkheir, Kheir Abou" uniqKey="Elkheir K" first="Kheir Abou" last="Elkheir">Kheir Abou Elkheir</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weber, Stefan" sort="Weber, Stefan" uniqKey="Weber S" first="Stefan" last="Weber">Stefan Weber</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khoury, Mary" sort="Khoury, Mary" uniqKey="Khoury M" first="Mary" last="Khoury">Mary Khoury</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donnelly, George" sort="Donnelly, George" uniqKey="Donnelly G" first="George" last="Donnelly">George Donnelly</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Younis, Naima" sort="Younis, Naima" uniqKey="Younis N" first="Naima" last="Younis">Naima Younis</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="El Saleh, Feda" sort="El Saleh, Feda" uniqKey="El Saleh F" first="Feda" last="El Saleh">Feda El Saleh</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abdalla, Muna" sort="Abdalla, Muna" uniqKey="Abdalla M" first="Muna" last="Abdalla">Muna Abdalla</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Health–Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Department of Health–Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imambaccus, Hala" sort="Imambaccus, Hala" uniqKey="Imambaccus H" first="Hala" last="Imambaccus">Hala Imambaccus</name>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea>Sheikh Khalifa Medical Laboratory, Abu Dhabi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M" last="Haynes">Lia M. Haynes</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J" last="Thornburg">Natalie J. Thornburg</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harcourt, Jennifer L" sort="Harcourt, Jennifer L" uniqKey="Harcourt J" first="Jennifer L" last="Harcourt">Jennifer L. Harcourt</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miao, Congrong" sort="Miao, Congrong" uniqKey="Miao C" first="Congrong" last="Miao">Congrong Miao</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hall, Aron J" sort="Hall, Aron J" uniqKey="Hall A" first="Aron J" last="Hall">Aron J. Hall</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Elizabeth S" sort="Russell, Elizabeth S" uniqKey="Russell E" first="Elizabeth S" last="Russell">Elizabeth S. Russell</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Aaron M" sort="Harris, Aaron M" uniqKey="Harris A" first="Aaron M" last="Harris">Aaron M. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="AF0003">United States Public Health Service, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>United States Public Health Service, Rockville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kiebler, Craig" sort="Kiebler, Craig" uniqKey="Kiebler C" first="Craig" last="Kiebler">Craig Kiebler</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mir, Roger A" sort="Mir, Roger A" uniqKey="Mir R" first="Roger A" last="Mir">Roger A. Mir</name>
<affiliation wicri:level="1"><nlm:aff id="AF0006">Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pringle, Kimberly" sort="Pringle, Kimberly" uniqKey="Pringle K" first="Kimberly" last="Pringle">Kimberly Pringle</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N" last="Alami">Negar N. Alami</name>
<affiliation wicri:level="1"><nlm:aff id="AF0005">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abedi, Glen R" sort="Abedi, Glen R" uniqKey="Abedi G" first="Glen R" last="Abedi">Glen R. Abedi</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I" last="Gerber">Susan I. Gerber</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec id="s1"><title>Background</title>
<p>Although there is evidence of person-to-person transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent to which disease severity affects transmission.</p>
</sec>
<sec id="s2"><title>Methods</title>
<p>A seroepidemiological investigation was conducted among MERS-CoV case patients (cases) and their household contacts to investigate transmission risk in Abu Dhabi, United Arab Emirates. Cases diagnosed between 1 January 2013 and 9 May 2014 and their household contacts were approached for enrollment. Demographic, clinical, and exposure history data were collected. Sera were screened by MERS-CoV nucleocapsid protein enzyme-linked immunosorbent assay and indirect immunofluorescence, with results confirmed by microneutralization assay.</p>
</sec>
<sec id="s3"><title>Results</title>
<p>Thirty-one of 34 (91%) case patients were asymptomatic or mildly symptomatic and did not require oxygen during hospitalization. MERS-CoV antibodies were detected in 13 of 24 (54%) case patients with available sera, including 1 severely symptomatic, 9 mildly symptomatic, and 3 asymptomatic case patients. No serologic evidence of MERS-CoV transmission was found among 105 household contacts with available sera.</p>
</sec>
<sec id="s4"><title>Conclusions</title>
<p>Transmission of MERS-CoV was not documented in this investigation of mostly asymptomatic and mildly symptomatic cases and their household contacts. These results have implications for clinical management of cases and formulation of isolation policies to reduce the risk of transmission.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ben Embarek, Pk" uniqKey="Ben Embarek P">PK Ben Embarek</name>
</author>
<author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name>
</author>
<author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name>
</author>
<author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Hosani, Fi" uniqKey="Al Hosani F">FI Al Hosani</name>
</author>
<author><name sortKey="Pringle, K" uniqKey="Pringle K">K Pringle</name>
</author>
<author><name sortKey="Al Mulla, M" uniqKey="Al Mulla M">M Al Mulla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alshukairi, An" uniqKey="Alshukairi A">AN Alshukairi</name>
</author>
<author><name sortKey="Khalid, I" uniqKey="Khalid I">I Khalid</name>
</author>
<author><name sortKey="Ahmed, Wa" uniqKey="Ahmed W">WA Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name>
</author>
<author><name sortKey="Perera, R" uniqKey="Perera R">R Perera</name>
</author>
<author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Iblan, I" uniqKey="Iblan I">I Iblan</name>
</author>
<author><name sortKey="Rha, B" uniqKey="Rha B">B Rha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Min, Ck" uniqKey="Min C">CK Min</name>
</author>
<author><name sortKey="Cheon, S" uniqKey="Cheon S">S Cheon</name>
</author>
<author><name sortKey="Ha, Ny" uniqKey="Ha N">NY Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name>
</author>
<author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name>
</author>
<author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name>
</author>
<author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name>
</author>
<author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name>
</author>
<author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arwady, Ma" uniqKey="Arwady M">MA Arwady</name>
</author>
<author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B Alraddadi</name>
</author>
<author><name sortKey="Basler, C" uniqKey="Basler C">C Basler</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name>
</author>
<author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hunter, Jc" uniqKey="Hunter J">JC Hunter</name>
</author>
<author><name sortKey="Nguyen, D" uniqKey="Nguyen D">D Nguyen</name>
</author>
<author><name sortKey="Aden, B" uniqKey="Aden B">B Aden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name>
</author>
<author><name sortKey="Al Salmi, Hs" uniqKey="Al Salmi H">HS Al-Salmi</name>
</author>
<author><name sortKey="Jacobs Slifka, K" uniqKey="Jacobs Slifka K">K Jacobs-Slifka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name>
</author>
<author><name sortKey="Arifi, Aa" uniqKey="Arifi A">AA Arifi</name>
</author>
<author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name>
</author>
<author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name>
</author>
<author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name>
</author>
<author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name>
</author>
<author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name>
</author>
<author><name sortKey="Jung, Hd" uniqKey="Jung H">HD Jung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ko, Jh" uniqKey="Ko J">JH Ko</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Seok, H" uniqKey="Seok H">H Seok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Albarrak, Am" uniqKey="Albarrak A">AM Albarrak</name>
</author>
<author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name>
</author>
<author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name>
</author>
<author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Gethamy, M" uniqKey="Al Gethamy M">M Al-Gethamy</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Hussain, R" uniqKey="Hussain R">R Hussain</name>
</author>
<author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hall, Aj" uniqKey="Hall A">AJ Hall</name>
</author>
<author><name sortKey="Tokars, Ji" uniqKey="Tokars J">JI Tokars</name>
</author>
<author><name sortKey="Badreddine, Sa" uniqKey="Badreddine S">SA Badreddine</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">cid</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29905769</article-id>
<article-id pub-id-type="pmc">7108211</article-id>
<article-id pub-id-type="doi">10.1093/cid/ciy503</article-id>
<article-id pub-id-type="publisher-id">ciy503</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject>
</subj-group>
</article-categories>
<title-group><article-title>Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Al Hosani</surname>
<given-names>Farida Ismail</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="author-notes" rid="fn-0001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Lindsay</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="author-notes" rid="fn-0001"></xref>
<xref ref-type="corresp" rid="c1"></xref>
<pmc-comment>lkim@cdc.gov </pmc-comment>
</contrib>
<contrib contrib-type="author"><name><surname>Khudhair</surname>
<given-names>Ahmed</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pham</surname>
<given-names>Huong</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al Mulla</surname>
<given-names>Mariam</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al Bandar</surname>
<given-names>Zyad</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pradeep</surname>
<given-names>Krishna</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elkheir</surname>
<given-names>Kheir Abou</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weber</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khoury</surname>
<given-names>Mary</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Donnelly</surname>
<given-names>George</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Younis</surname>
<given-names>Naima</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>El Saleh</surname>
<given-names>Feda</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abdalla</surname>
<given-names>Muna</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Imambaccus</surname>
<given-names>Hala</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haynes</surname>
<given-names>Lia M</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thornburg</surname>
<given-names>Natalie J</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harcourt</surname>
<given-names>Jennifer L</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miao</surname>
<given-names>Congrong</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tamin</surname>
<given-names>Azaibi</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Aron J</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russell</surname>
<given-names>Elizabeth S</given-names>
</name>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harris</surname>
<given-names>Aaron M</given-names>
</name>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kiebler</surname>
<given-names>Craig</given-names>
</name>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mir</surname>
<given-names>Roger A</given-names>
</name>
<xref ref-type="aff" rid="AF0006">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pringle</surname>
<given-names>Kimberly</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alami</surname>
<given-names>Negar N</given-names>
</name>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abedi</surname>
<given-names>Glen R</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerber</surname>
<given-names>Susan I</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
Department of Health–Abu Dhabi, United Arab Emirates</aff>
<aff id="AF0002"><label>2</label>
Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia</aff>
<aff id="AF0003"><label>3</label>
United States Public Health Service, Rockville, Maryland</aff>
<aff id="AF0004"><label>4</label>
Sheikh Khalifa Medical Laboratory, Abu Dhabi, United Arab Emirates</aff>
<aff id="AF0005"><label>5</label>
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</aff>
<aff id="AF0006"><label>6</label>
Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia</aff>
<author-notes><fn id="fn-0001"><p>F. I. A. H. and L. K. contributed equally to this work.</p>
</fn>
<corresp id="c1">Correspondence: L. Kim, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-A34, Atlanta, GA 30329 (<email>lkim@cdc.gov</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>2</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2018-06-13"><day>13</day>
<month>6</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>6</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and
0 days and was based on the . </pmc-comment>
<volume>68</volume>
<issue>3</issue>
<fpage>409</fpage>
<lpage>418</lpage>
<history><date date-type="received"><day>08</day>
<month>2</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>12</day>
<month>6</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>Published by Oxford University Press for the Infectious Diseases Society of America 2018.</copyright-statement>
<copyright-year>2018</copyright-year>
<license license-type="us-gov"><license-p>This work is written by (a) US Government employee(s) and is in the public domain in the US.</license-p>
</license>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
</permissions>
<self-uri xlink:href="ciy503.pdf"></self-uri>
<abstract><title>Abstract</title>
<sec id="s1"><title>Background</title>
<p>Although there is evidence of person-to-person transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent to which disease severity affects transmission.</p>
</sec>
<sec id="s2"><title>Methods</title>
<p>A seroepidemiological investigation was conducted among MERS-CoV case patients (cases) and their household contacts to investigate transmission risk in Abu Dhabi, United Arab Emirates. Cases diagnosed between 1 January 2013 and 9 May 2014 and their household contacts were approached for enrollment. Demographic, clinical, and exposure history data were collected. Sera were screened by MERS-CoV nucleocapsid protein enzyme-linked immunosorbent assay and indirect immunofluorescence, with results confirmed by microneutralization assay.</p>
</sec>
<sec id="s3"><title>Results</title>
<p>Thirty-one of 34 (91%) case patients were asymptomatic or mildly symptomatic and did not require oxygen during hospitalization. MERS-CoV antibodies were detected in 13 of 24 (54%) case patients with available sera, including 1 severely symptomatic, 9 mildly symptomatic, and 3 asymptomatic case patients. No serologic evidence of MERS-CoV transmission was found among 105 household contacts with available sera.</p>
</sec>
<sec id="s4"><title>Conclusions</title>
<p>Transmission of MERS-CoV was not documented in this investigation of mostly asymptomatic and mildly symptomatic cases and their household contacts. These results have implications for clinical management of cases and formulation of isolation policies to reduce the risk of transmission.</p>
</sec>
</abstract>
<abstract abstract-type="teaser"><p>Transmission of Middle East respiratory syndrome coronavirus was not documented in this seroepidemiologic follow-up investigation of mostly asymptomatic and mildly symptomatic cases and their household contacts. This may have implications for isolation policies to reduce risk of transmission to others.</p>
</abstract>
<kwd-group><kwd>Middle East respiratory syndrome coronavirus</kwd>
<kwd>asymptomatic infection</kwd>
<kwd>serology</kwd>
<kwd>transmission</kwd>
<kwd>United Arab Emirates</kwd>
</kwd-group>
<funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">Centers for Disease Control and Prevention</named-content>
<named-content content-type="funder-identifier">10.13039/100000030</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B81 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000B81 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:7108211 |texte= Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:29905769" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |