Serveur d'exploration MERS

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Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk

Identifieur interne : 000A44 ( Pmc/Curation ); précédent : 000A43; suivant : 000A45

Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk

Auteurs : Jaffar A. Al-Tawfiq [Arabie saoudite, États-Unis] ; Ziad A. Memish [Arabie saoudite, États-Unis]

Source :

RBID : PMC:7115296

Abstract

Background

An important emerging respiratory virus is the Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV had been associated with a high case fatality rate especially among severe cases.

Methods

This is a retrospective analysis of reported MERS-CoV cases between December 2016 and January 2019, as retrieved from the World Health Organization. The aim of this study is to examine the epidemiology of reported cases and quantify the percentage of health care workers (HCWs) among reported cases.

Results

There were 403 reported cases with a majority being men (n = 300; 74.4%). These cases were reported from Lebanon, Malaysia, Oman, Qatar, Saudi Arabia, and United Arab Emirates. HCWs represented 26% and comorbidities were reported among 71% of non-HCWs and 1.9% among HCWs (P < .0001). Camel exposure and camel milk ingestion were reported in 64% each, and the majority (97.8%) of those with camel exposures had camel milk ingestion. There were 58% primary cases and 42% were secondary cases. The case fatality rate was 16% among HCWs compared with 34% among other patients (P = .001). The mean age ± SD was 47.65 ± 16.28 for HCWs versus 54.23 ± 17.34 for non-HCWs (P = .001).

Conclusions

MERS-CoV infection continues to have a high case fatality rate and a large proportion of patients were HCWs. Further understanding of the disease transmission and prevention mainly in health care settings are needed.


Url:
DOI: 10.1016/j.ajic.2019.04.007
PubMed: 31128983
PubMed Central: 7115296

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PMC:7115296

Le document en format XML

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<p>An important emerging respiratory virus is the Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV had been associated with a high case fatality rate especially among severe cases.</p>
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<title>Methods</title>
<p>This is a retrospective analysis of reported MERS-CoV cases between December 2016 and January 2019, as retrieved from the World Health Organization. The aim of this study is to examine the epidemiology of reported cases and quantify the percentage of health care workers (HCWs) among reported cases.</p>
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<p>There were 403 reported cases with a majority being men (n = 300; 74.4%). These cases were reported from Lebanon, Malaysia, Oman, Qatar, Saudi Arabia, and United Arab Emirates. HCWs represented 26% and comorbidities were reported among 71% of non-HCWs and 1.9% among HCWs (
<italic>P</italic>
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<italic>P</italic>
 = .001). The mean age ± SD was 47.65 ± 16.28 for HCWs versus 54.23 ± 17.34 for non-HCWs (
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<p>MERS-CoV infection continues to have a high case fatality rate and a large proportion of patients were HCWs. Further understanding of the disease transmission and prevention mainly in health care settings are needed.</p>
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</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Am J Infect Control</journal-id>
<journal-id journal-id-type="iso-abbrev">Am J Infect Control</journal-id>
<journal-title-group>
<journal-title>American Journal of Infection Control</journal-title>
</journal-title-group>
<issn pub-type="ppub">0196-6553</issn>
<issn pub-type="epub">1527-3296</issn>
<publisher>
<publisher-name>Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">31128983</article-id>
<article-id pub-id-type="pmc">7115296</article-id>
<article-id pub-id-type="publisher-id">S0196-6553(19)30235-4</article-id>
<article-id pub-id-type="doi">10.1016/j.ajic.2019.04.007</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="au0001">
<name>
<surname>Al-Tawfiq</surname>
<given-names>Jaffar A.</given-names>
</name>
<degrees>MD, FACP, FRCP</degrees>
<email>jaltawfi@yahoo.com</email>
<xref rid="aff0001" ref-type="aff">a</xref>
<xref rid="aff0002" ref-type="aff">b</xref>
<xref rid="aff0003" ref-type="aff">c</xref>
<xref rid="aff0004" ref-type="aff">d</xref>
<xref rid="cor0001" ref-type="corresp"></xref>
</contrib>
<contrib contrib-type="author" id="au0002">
<name>
<surname>Memish</surname>
<given-names>Ziad A.</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff0005" ref-type="aff">e</xref>
<xref rid="aff0006" ref-type="aff">f</xref>
<xref rid="aff0007" ref-type="aff">g</xref>
</contrib>
</contrib-group>
<aff id="aff0001">
<label>a</label>
Specialty Internal Medicine Unit, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia</aff>
<aff id="aff0002">
<label>b</label>
Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia</aff>
<aff id="aff0003">
<label>c</label>
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</aff>
<aff id="aff0004">
<label>d</label>
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff>
<aff id="aff0005">
<label>e</label>
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</aff>
<aff id="aff0006">
<label>f</label>
Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital (“PMAH”), Ministry of Health, Riyadh, Saudi Arabia</aff>
<aff id="aff0007">
<label>g</label>
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA</aff>
<author-notes>
<corresp id="cor0001">
<label></label>
Address correspondence to Jaffar A. Al-Tawfiq, MD, FACP, FRCP, Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran Health Center, PO Box 76, Room A-428-2, Building 61, Saudi Aramco, Dhahran 31311, Saudi Arabia.
<email>jaltawfi@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release">
<day>23</day>
<month>5</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>23</day>
<month>5</month>
<year>2019</year>
</pub-date>
<volume>47</volume>
<issue>10</issue>
<fpage>1167</fpage>
<lpage>1170</lpage>
<permissions>
<copyright-statement>© 2019 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Association for Professionals in Infection Control and Epidemiology, Inc.</copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0001">
<sec>
<title>Background</title>
<p>An important emerging respiratory virus is the Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV had been associated with a high case fatality rate especially among severe cases.</p>
</sec>
<sec>
<title>Methods</title>
<p>This is a retrospective analysis of reported MERS-CoV cases between December 2016 and January 2019, as retrieved from the World Health Organization. The aim of this study is to examine the epidemiology of reported cases and quantify the percentage of health care workers (HCWs) among reported cases.</p>
</sec>
<sec>
<title>Results</title>
<p>There were 403 reported cases with a majority being men (n = 300; 74.4%). These cases were reported from Lebanon, Malaysia, Oman, Qatar, Saudi Arabia, and United Arab Emirates. HCWs represented 26% and comorbidities were reported among 71% of non-HCWs and 1.9% among HCWs (
<italic>P</italic>
< .0001). Camel exposure and camel milk ingestion were reported in 64% each, and the majority (97.8%) of those with camel exposures had camel milk ingestion. There were 58% primary cases and 42% were secondary cases. The case fatality rate was 16% among HCWs compared with 34% among other patients (
<italic>P</italic>
 = .001). The mean age ± SD was 47.65 ± 16.28 for HCWs versus 54.23 ± 17.34 for non-HCWs (
<italic>P</italic>
 = .001).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>MERS-CoV infection continues to have a high case fatality rate and a large proportion of patients were HCWs. Further understanding of the disease transmission and prevention mainly in health care settings are needed.</p>
</sec>
</abstract>
<kwd-group id="keys0001">
<title>Key Words</title>
<kwd>Middle East Respiratory Syndrome Coronavirus</kwd>
<kwd>MERS</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Healthcare workers</kwd>
<kwd>transmission</kwd>
<kwd>emerging infectious disease</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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